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David S. Yu
Emory University
CancerRadiologyDNA repairMolecular biologyMedicine
96Publications
20H-index
2,052Citations
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Publications 95
Newest
#1Yang LeiH-Index: 8
#2Joseph HarmsH-Index: 1
Last. Xiaofeng YangH-Index: 15
view all 10 authors...
Radiation treatment for head-and-neck (HN) cancers requires accurate treatment planning based on 3D patient models derived from CT images. In clinical practice, the treatment volumes and organs-at-risk (OARs) are manually contoured by experienced physicians. This tedious and time-consuming procedure limits clinical workflow and resources. In this work, we propose to use a 3D Faster R-CNN to automatically detect the location of head and neck organs, then apply a U-Net to segment the multi-organ c...
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#1Yabo FuH-Index: 1
#2Yang LeiH-Index: 8
Last. Xiaofeng YangH-Index: 15
view all 9 authors...
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#1Erica Werner (Emory University)H-Index: 19
#2Andrew Alter (Emory University)
Last. Paul W. Doetsch (Emory University)H-Index: 39
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While evidence supporting the notion that exposures to heavy ion radiation increase the risk for cancer and other disease development is accumulating, the underlying biological mechanisms remain poorly understood. To identify novel phenotypes that persist over time that may be related to increased disease development risk, we performed a quantitative global proteome analysis of immortalized human bronchial epithelial cells (HBEC3-KT) at day 7 post exposure to 0.5 Gy Fe ion (600 MeV/nucleon, Line...
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#1Guo Chen (Emory University)H-Index: 12
#2Yin Luo (Emory University)
Last. Xingming Deng (Emory University)H-Index: 34
view all 13 authors...
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here, we report that acetylation and deacetylation of the RRM2 subunit of RNR acts as a molecular switch that impacts RNR activity, dNTP synthesis, and DNA replication fork progression. Acetylation of RRM2 at K95 abrogates RNR activity by disrupting its homodimer assembly. RRM2 is directly acetylated by KAT7, and deacetylated by Sirt2, respectiv...
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#1Hui Zhang (Emory University)H-Index: 9
#2PamelaSara E. Head (Emory University)H-Index: 4
Last. David S. Yu (Emory University)H-Index: 20
view all 5 authors...
The DNA damage response (DDR) is a signaling network that recognizes damages to DNA and orchestrates a variety of DNA repair and cell cycle checkpoint pathways. The DDR is pivotal for cancer prevention. Ataxia Telangiectasia And Rad3-Related Protein (ATR), a protein kinase, functions as an essential transducer of the DDR signaling cascade. ATR primarily responds to single-stranded DNA (ssDNA) generated from double-strand break resection or at stalled replication forks. Depletion of ATR leads to ...
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#1PamelaSara E. Head (Emory University)H-Index: 4
#2Nagaraju P. Ganji (Emory University)
Last. David S. Yu (Emory University)H-Index: 20
view all 15 authors...
DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in response to ionizing radiation (IR) to govern genome integrity. How DNA-PK is activated in response to DSBs has remained elusive. Here, we show that the SIRT2 sirtuin deacetylase and tumor suppressor directs the activation of DNA-PK through deacetylation of its catalytic subunit (DNA-PKcs). SIRT2 deacetylase activity governs cell...
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#1Elizabeth MintenH-Index: 1
#2Hui ZhangH-Index: 9
Last. David S. YuH-Index: 20
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#1Elizabeth Minten (Emory University)H-Index: 1
#2David S. Yu (Emory University)H-Index: 20
Abstract It has been well established that an accumulation of mutations in DNA, whether caused by external sources (e.g. ultraviolet light, radioactivity) or internal sources (e.g. metabolic by-products, such as reactive oxygen species), has the potential to cause a cell to undergo carcinogenesis and increase the risk for the development of cancer. Therefore, it is critically important for a cell to have the capacity to properly respond to and repair DNA damage as it occurs. The DNA damage respo...
1 CitationsSource
#1Sibo Tian (Emory University)H-Index: 5
#2Jeffrey M. Switchenko (Emory University)H-Index: 11
Last. Jonathan J. Beitler M. D. M. B. A. Facr (Emory University)H-Index: 34
view all 15 authors...
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#1Xiaofeng YangH-Index: 15
#2Yang LeiH-Index: 8
Last. Tonghe WangH-Index: 7
view all 13 authors...
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