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Chawnshang Chang
University of Rochester
549Publications
86H-index
28kCitations
Publications 529
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Abstract IDH1 (Isocitrate dehydrogenase 1) mutation occurring at codon 132 (R132) in prostate cancer (PCa) is considered as a classifier for a subgroup of PCas with accumulation of oncometabolite R-2HG (R-2-hydroxyglutarate). Here we found that adding R-2HG or the mutant IDH1 R132H could promote PCa cell invasion in androgen receptor (AR)-negative PC3 cells or suppressing the AR in AR-positive C4-2 cells. Mechanism dissection revealed that R-2HG could increase circRNA-51217 expression to increas...
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#1Jie Luo (UR: University of Rochester)H-Index: 13
#2Keliang Wang (UR: University of Rochester)H-Index: 1
Last.Chawnshang Chang (UR: University of Rochester)H-Index: 86
view all 12 authors...
While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer (CRPC) patients’ survival an extra 4.8 months, it might also result in some adverse effects via inducing the neuroendocrine differentiation (NED). Here we found that lncRNA-p21 is highly expressed in the NEPC patients derived xenograft tissues (NEPC-PDX). Results from cell lines and human clinical sample surveys also revealed that lncRNA-p21 expression is up-regulated in NEPC and Enz treatment could increa...
1 CitationsSource
#1Chi-Ping Huang (PRC: China Medical University (PRC))H-Index: 5
#2Jinbo Chen (URMC: University of Rochester Medical Center)H-Index: 6
Last.Chawnshang Chang (URMC: University of Rochester Medical Center)H-Index: 86
view all 8 authors...
Background The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) for a few months, but eventually most patients succumb to disease because they develop resistance to their chemotherapy.
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Prostate cancer (PCa) is the second leading cause of cancer death in men in America, and there are no curative options for metastatic castration-resistant prostate cancer (mCRPC). Docetaxel (DTX) has been used as a standard chemotherapy for the mCRPC. However, resistance to DTX is a significant clinical problem as half of patients fail to respond to therapy. The TR4 nuclear receptor has been reported to play an important role in PCa progression, however, its linkage to the DTX resistance remains...
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#1Jinbo Chen (UR: University of Rochester)H-Index: 2
#2Fu-Ju Chou (UR: University of Rochester)
Last.Chawnshang Chang (UR: University of Rochester)H-Index: 86
view all 11 authors...
While androgens may function via nuclear androgen receptor (nAR) to increase bladder cancer (BCa) progression, the impact of androgens on muscle invasive BCa, which contains nearly 80% nAR-negative cells, remains unclear. To dissect the androgens potential impacts on these nAR-negative muscle invasive BCa, we first found that the androgens, dihydrotestosterone (DHT) might function via a novel membrane AR (mAR-SLC39A9) to increase nAR-negative BCa cell migration and invasion. Mechanism dissection...
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#1Hangchuan Shi (URMC: University of Rochester Medical Center)
#2Yin Sun (URMC: University of Rochester Medical Center)H-Index: 21
Last.Chawnshang Chang (URMC: University of Rochester Medical Center)H-Index: 86
view all 8 authors...
Renal cell carcinoma (RCC) is one of the most lethal urological tumors. Using sunitinib to improve the survival has become the first-line therapy for metastatic RCC patients. However, the occurrence of sunitinib resistance in the clinical application has curtailed its efficacy. Here we found TR4 nuclear receptor might alter the sunitinib resistance to RCC via altering the TR4/lncTASR/AXL signaling. Mechanism dissection revealed that TR4 could modulate lncTASR (ENST00000600671.1) expression via t...
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#1Yi-Yung HungH-Index: 5
#2Ya-Ling HuangH-Index: 1
Last.Hong-Yo KangH-Index: 21
view all 4 authors...
While androgen receptor (AR) and stress may influence the development of the major depressive disorder (MDD), the detailed relationship, however, remains unclear. Here we found loss of AR accelerated development of depressive-like behaviors in mice under chronic mild stress (CMS). Mechanism dissection indicated that AR might function via altering the expression of miR-204-5p to modulate the brain-derived neurotrophic factor (BDNF) expression to influence the depressive-like behaviors in the mice...
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#1Jie Zhao (SRRSH: Sir Run Run Shaw Hospital)H-Index: 5
#2Yin Sun (UR: University of Rochester)H-Index: 21
Last.Chawnshang Chang (URMC: University of Rochester Medical Center)H-Index: 86
view all 8 authors...
Hepatocellular carcinoma (HCC) is one of most common malignant tumors worldwide, however, the treatment for advanced HCC remains unsatisfactory. Here we found that Olaparib, a FDA approved PARP inhibitor, could enhance the cytotoxicity in HCC cells with a lower BRCA1 expression, and suppressing the AR with either Enz or AR-shRNA could further increase the Olaparib sensitivity to better suppress the HCC cell growth via a synergistic mechanism that may involve suppressing the expression of BRCA1 a...
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#1Shimiao Zhu (Tianjin Medical University)H-Index: 10
#2Hao Tian (Tianjin Medical University)H-Index: 2
Last.Yuanjie Niu (Tianjin Medical University)H-Index: 22
view all 15 authors...
Castration-resistant prostate cancer (CRPC) with neuroendocrine differentiation (NED) is a lethal disease for which effective therapies are urgently needed. The mechanism underlying development of CRPC with NED, however, remains largely uncharacterized. In this study, we explored and characterized the functional role of neurotensin (NTS) in cell line and animal models of CRPC with NED. NTS was acutely induced by androgen deprivation in animal models of prostate cancer (PCa) and activated downstr...
1 CitationsSource
#1Shimiao Zhu (Tianjin Medical University)H-Index: 10
#2Hao Tian (Tianjin Medical University)H-Index: 2
Last.Yuanjie Niu (Tianjin Medical University)H-Index: 22
view all 15 authors...
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