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Leonor M. Almeida
University of Coimbra
90Publications
31H-index
4,782Citations
Publications 90
Newest
#1Paula M. Brito (UC: University of Coimbra)H-Index: 10
#2Raphaël Devillard (French Institute of Health and Medical Research)H-Index: 4
Last.Nathalie Augé (French Institute of Health and Medical Research)H-Index: 26
view all 7 authors...
#1Leonor MeiraH-Index: 2
#2Catarina Chaves (RMIT: RMIT University)H-Index: 2
Last.Fernando Rodrigues (RMIT: RMIT University)H-Index: 29
view all 10 authors...
Abstract Setting University-affiliated hospital located in Porto, North Portugal, an area with a low to intermediate incidence of tuberculosis (TB). Objective To identify predictors and outcomes of disseminated TB (dTB). Design A cohort of patients diagnosed with TB between 2007 and 2013 was retrospectively analysed. Patients with dTB criteria were characterized and compared to single organ TB cases. Factors independently associated with dTB were determined by multivariate logistic regression an...
#1Carla Nunes (UC: University of Coimbra)H-Index: 14
#2Victor de Freitas (University of Porto)H-Index: 46
Last.João Laranjinha (UC: University of Coimbra)H-Index: 30
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The altered expression and subcellular distribution of tight junction (TJ) proteins, leading to a dysfunctional intestinal barrier, is a key mechanistic feature of inflammatory bowel disease (IBD). Therefore, increasing the integrity of the intestinal barrier by manipulating the TJ may constitute an innovative and effective therapeutic strategy in IBD. In this context, recent studies showed that dietary polyphenols are able to protect the intestinal TJ barrier integrity. Here, using a cellular m...
The release of reactive oxygen species (ROS) and pro-inflammatory mediators is a critical event in triggering and perpetuating inflammatory diseases, such as inflammatory bowel disease (IBD). 5-Aminosalicylic acid (5-ASA) is an antioxidant and anti-inflammatory drug currently used in IBD, but dietary compounds such as anthocyanins have been gaining popularity as a complementary strategy. Thus, this study aimed to evaluate the ability of cyanidin-3-glucoside (Cy3glc), a major dietary anthocyanin,...
#1Diana Serra (UC: University of Coimbra)H-Index: 5
#2Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
Last.Teresa C.P. Dinis (UC: University of Coimbra)H-Index: 21
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Dietary polyphenols have been considered as a valuable strategy to combat chronic disorders, such as Inflammatory Bowel Disease (IBD). The aim of this study was to scrutinize the biochemical mechanisms behind the anti-inflammatory effects of a well-known polyphenol, Resveratrol (Resv), comparing them to those of a first-line therapy for IBD, the 5 aminosalicylic acid (5 ASA), using a human intestinal cell line (HT 29). In cytokine-treated cells, Resv significantly inhibited the production of sev...
#1Leonor M. AlmeidaH-Index: 31
#2Bruno LimaH-Index: 5
Last.A. MoraisH-Index: 5
view all 9 authors...
Abstract Introduction Transbronchial lung cryobiopsy (TBLC) is increasingly used in the diagnosis of diffuse lung disease (DLD), but no data have yet been published on the learning curve associated with this technique. Aim To evaluate diagnostic yield, lung tissue sample length and area, and procedure-related complications in a cohort of TBLC procedures to define the learning curve and threshold for proficiency. Methods Retrospective analysis of the first 100 TBLCs performed in different segment...
#1Sílvia Cristina Pereira da Silva (UC: University of Coimbra)H-Index: 9
#2Teresa C.P. Dinis (UC: University of Coimbra)H-Index: 21
Last.Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
view all 3 authors...
The overproduction of reactive oxygen species (ROS) and pro-inflammatory mediators is closely related with inflammatory diseases, such as inflammatory bowel disease (IBD). Despite the advances in therapeutics, new and safer strategies are still required. In this context, anthocyanins, highly available in human diet and recognized as health-promoting agents, have been a focus of interest. Thus, the aim of this work was to study the anti-inflammatory potential of a characterized anthocyanin-rich f...
#1Sónia R. Pereira (UC: University of Coimbra)H-Index: 1
#2Rita Pereira (UC: University of Coimbra)H-Index: 1
Last.Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
view all 6 authors...
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms and efficacy as compared with established drugs still require more clarification. The main aim of this study was to compare the anti-inflammatory action of a chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese bluebe...
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