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Leonor M. Almeida
University of Coimbra
ChemistryAntioxidantLipid peroxidationMitochondrionBiochemistry
84Publications
31H-index
4,843Citations
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Publications 80
Newest
#1Sónia R. Pereira (UC: University of Coimbra)H-Index: 1
#2Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
Last. Teresa C.P. Dinis (UC: University of Coimbra)H-Index: 21
view all 3 authors...
Abstract This study investigated the anti-inflammatory action of cyanidin-3-glucoside (Cy3glc), an anthocyanin widely spread in diet, in comparison and in association with 5-aminosalicylic acid (5-ASA), an anti-inflammatory reference drug for ulcerative colitis. The efficacy, action mechanism and interaction between Cy3glc and 5-ASA were assessed in vitro, in an LPS-activated macrophage cell line. Our data showed a higher effectiveness of Cy3glc in counteracting inflammatory mediators as compare...
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#1Paula M. Brito (UC: University of Coimbra)H-Index: 10
#2Raphaël Devillard (French Institute of Health and Medical Research)H-Index: 6
Last. Nathalie Augé (French Institute of Health and Medical Research)H-Index: 27
view all 7 authors...
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#1Carla Nunes (UC: University of Coimbra)H-Index: 15
#2Victor de Freitas (University of Porto)H-Index: 49
Last. João Laranjinha (UC: University of Coimbra)H-Index: 30
view all 4 authors...
The altered expression and subcellular distribution of tight junction (TJ) proteins, leading to a dysfunctional intestinal barrier, is a key mechanistic feature of inflammatory bowel disease (IBD). Therefore, increasing the integrity of the intestinal barrier by manipulating the TJ may constitute an innovative and effective therapeutic strategy in IBD. In this context, recent studies showed that dietary polyphenols are able to protect the intestinal TJ barrier integrity. Here, using a cellular m...
2 CitationsSource
#1Rita BoaventuraH-Index: 2
#2Leonor M. AlmeidaH-Index: 31
Last. Marta DrummondH-Index: 11
view all 11 authors...
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#1Diana Serra (UC: University of Coimbra)H-Index: 6
#2Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
Last. Teresa C.P. Dinis (UC: University of Coimbra)H-Index: 21
view all 3 authors...
Dietary polyphenols have been considered as a valuable strategy to combat chronic disorders, such as Inflammatory Bowel Disease (IBD). The aim of this study was to scrutinize the biochemical mechanisms behind the anti-inflammatory effects of a well-known polyphenol, Resveratrol (Resv), comparing them to those of a first-line therapy for IBD, the 5 aminosalicylic acid (5 ASA), using a human intestinal cell line (HT 29). In cytokine-treated cells, Resv significantly inhibited the production of sev...
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The release of reactive oxygen species (ROS) and pro-inflammatory mediators is a critical event in triggering and perpetuating inflammatory diseases, such as inflammatory bowel disease (IBD). 5-Aminosalicylic acid (5-ASA) is an antioxidant and anti-inflammatory drug currently used in IBD, but dietary compounds such as anthocyanins have been gaining popularity as a complementary strategy. Thus, this study aimed to evaluate the ability of cyanidin-3-glucoside (Cy3glc), a major dietary anthocyanin,...
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#1Leonor M. AlmeidaH-Index: 31
#2Bruno A. LimaH-Index: 6
Last. A. MoraisH-Index: 6
view all 9 authors...
Abstract Introduction Transbronchial lung cryobiopsy (TBLC) is increasingly used in the diagnosis of diffuse lung disease (DLD), but no data have yet been published on the learning curve associated with this technique. Aim To evaluate diagnostic yield, lung tissue sample length and area, and procedure-related complications in a cohort of TBLC procedures to define the learning curve and threshold for proficiency. Methods Retrospective analysis of the first 100 TBLCs performed in different segment...
5 CitationsSource
#1Sílvia Cristina Pereira da Silva (UC: University of Coimbra)H-Index: 7
#2Teresa C.P. Dinis (UC: University of Coimbra)H-Index: 21
Last. Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
view all 3 authors...
The overproduction of reactive oxygen species (ROS) and pro-inflammatory mediators is closely related with inflammatory diseases, such as inflammatory bowel disease (IBD). Despite the advances in therapeutics, new and safer strategies are still required. In this context, anthocyanins, highly available in human diet and recognized as health-promoting agents, have been a focus of interest. Thus, the aim of this work was to study the anti-inflammatory potential of a characterized anthocyanin-rich f...
1 CitationsSource
#1Sónia R. Pereira (UC: University of Coimbra)H-Index: 1
#2Rita Pereira (UC: University of Coimbra)H-Index: 1
Last. Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
view all 6 authors...
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms and efficacy as compared with established drugs still require more clarification. The main aim of this study was to compare the anti-inflammatory action of a chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese bluebe...
15 CitationsSource
#1Carla Nunes (UC: University of Coimbra)H-Index: 15
#2Leonor M. Almeida (UC: University of Coimbra)H-Index: 31
Last. João Laranjinha (UC: University of Coimbra)H-Index: 30
view all 4 authors...
Current treatment strategies for inflammatory bowel diseases (IBDs) are associated with a lower efficacy and with several side effects that strongly affect the quality of life of IBD patients. Consequently, the development of new therapies, combining efficacy and safety is an important goal in the field of intestinal inflammation. In this context, evidence supports that polyphenols can be promising candidates due to their ability to modulate intracellular inflammatory signalling cascades. Luteol...
15 CitationsSource
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