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Maude Schneider
University of Geneva
PsychiatryDevelopmental psychologyPsychologyPsychosisSchizophrenia
81Publications
20H-index
1,267Citations
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Publications 89
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#1Valentina Mancini (University of Geneva)H-Index: 1
#2Daniela Zöller (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 4
Last. Stephan Eliez (University of Geneva)H-Index: 50
view all 5 authors...
Abstract Background Several studies in patients with schizophrenia have demonstrated an abnormal thalamic volume and thalamocortical connectivity. Specifically, hyperconnectivity with somatosensory areas has been related to the presence of auditory hallucinations (AH). The 22q11.2 deletion syndrome is a neurogenetic disorder conferring proneness to develop schizophrenia and deletion carriers (22qdel) experience hallucinations to a greater extent than the general population. Methods We acquired 4...
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#1Johanna Maeder (University of Geneva)H-Index: 4
#2Corrado Sandini (University of Geneva)H-Index: 4
Last. Stephan Eliez (University of Geneva)H-Index: 50
view all 9 authors...
ABSTRACTChromosome 22q11.2 deletion syndrome (22q11.2DS) is a genetic disease associated with an increased risk for schizophrenia and a specific cognitive profile. In this paper, we challenge the c...
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#1Lydia DubourgH-Index: 2
#2Johanna MaederH-Index: 4
Last. Maude SchneiderH-Index: 20
view all 5 authors...
Background: Negative symptoms and social dysfunction are core features of the 22q11.2 deletion syndrome (22q11DS). Negative symptoms have been conceptualized as pathology of goal-directed-behaviors. Moreover, goal-directed-behaviors also appear to be a crucial step of social interactions. However, in 22q11DS, the extent to which goal-directed-behavior could be linked to social functioning difficulties and negative symptoms has never been examined. Method: Verbal and nonverbal initiation was meas...
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#1Corrado Sandini (University of Geneva)H-Index: 4
#2Maelle Chambaz (University of Geneva)H-Index: 1
Last. Stephan Eliez (University of Geneva)H-Index: 50
view all 9 authors...
Abstract Background 22q11.2 Deletion Syndrome (22q11DS) confers strongly increased genetic risk for multiple psychiatric disorders. Similarly to the general population, rates of psychiatric comorbidity suggest that common disease mechanisms are shared across dimensions of psychopathology. Such pleiotropic disease mechanisms remain however currently unknown. We hypothesized that pituitary dysmaturation, indicative of HPA-axis dysregulation, could correlate to reduced tolerance to daily life stres...
1 CitationsSource
#1Marco Armando (University of Geneva)H-Index: 14
#2Mariasole Ciampoli (IIT: Istituto Italiano di Tecnologia)H-Index: 2
Last. Stephan Eliez (University of Geneva)H-Index: 50
view all 11 authors...
Abstract Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients’ genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by...
1 CitationsSource
#1Isabelle Cleynen (Katholieke Universiteit Leuven)H-Index: 26
#2Worrawat Engchuan (The Centre for Applied Genomics)H-Index: 6
Last. Bernice E. Morrow (Albert Einstein College of Medicine)H-Index: 46
view all 124 authors...
Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophre...
2 CitationsSource
#1Yingjie Zhao (Albert Einstein College of Medicine)H-Index: 1
#1Yingjie Zhao (Albert Einstein College of Medicine)
Last. Bernice E. Morrow (Albert Einstein College of Medicine)H-Index: 46
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The 22q11.2 deletion syndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22. About 60%–70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have congenital heart disease, mostly of the conotruncal type (CTD), whereas others have normal cardiac anatomy. In this study, we tested whether variants in the hemizygous LCR22A-D region are associated with risk for CTDs on the basis of the sequence of the 22q11.2 region from 1,053...
3 CitationsSource
#1Corrado SandiniH-Index: 4
#2Stephan EliezH-Index: 50
Last. Marco ArmandoH-Index: 14
view all 4 authors...
Abstract 22q11.2 Deletion Syndrome (22q11.2DS) is the single highest molecular risk factor for psychosis with over a third of affected patients developing schizophrenia by adulthood. Patients are moreover characteristically identified as children, due to their somatic phenotype, leading to the realization that the syndrome could serve as a unique window into the earliest clinical and neurodevelopmental stages of the pathophysiology of psychosis. Here we firstly present key notions regarding the ...
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#1Lydia Dubourg (University of Geneva)H-Index: 2
#2Pascal Vrti (MPG: Max Planck Society)H-Index: 13
Last. Maude Schneider (University of Geneva)H-Index: 20
view all 5 authors...
Abstract Aim The 22q11.2 deletion (22q11DS) syndrome is a neurogenetic condition marked by social dysfunction. A major network involved in social cognition is the default mode network (DMN). To date, no study has investigated DMN functional connectivity during socio-cognitive paradigms in 22q11DS. Method We used the psychophysiological analysis (PPI) to investigate functional connectivity of the DMN during social perception in 22 participants with 22q11DS and 22 healthy controls. Association bet...
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#1Valentina Mancini (University of Geneva)H-Index: 1
#2Corrado Sandini (University of Geneva)H-Index: 4
Last. Stephan Eliez (University of Geneva)H-Index: 50
view all 7 authors...
Low hippocampal volume is a consistent finding in schizophrenia and across the psychosis spectrum. However, there is a lack of studies investigating longitudinal hippocampal development and its relationship with psychotic symptoms. The 22q11.2 deletion syndrome (22q11DS) has proven to be a remarkable model for the prospective study of individuals at high risk of schizophrenia to unravel the pathophysiological processes predating the onset of psychosis. Repeated cerebral MRIs were acquired from 1...
1 CitationsSource
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