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Christian A. Webb
Harvard University
47Publications
18H-index
1,198Citations
Publications 48
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#2Courtney Beard (Harvard University)H-Index: 22
Last.Christian A. Webb (Harvard University)H-Index: 18
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Background: Individuals with emotional disorders often have comorbid relationship problems, and improving interpersonal functioning is a common goal of treatment. Research indicates that the therapeutic alliance is associated with broad symptom improvement; however, no study has examined whether the alliance promotes improved interpersonal functioning for individuals with emotional disorders and varying levels of interpersonal difficulties. The present study tested whether improvement in the all...
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#1Christian A. Webb (Harvard University)H-Index: 18
#2Madhukar H. TrivediH-Index: 91
Last.Diego A. Pizzagalli (Harvard University)H-Index: 60
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Background Major depressive disorder (MDD) is a highly heterogeneous condition in terms of symptom presentation and, likely, underlying pathophysiology. Accordingly, it is possible that only certain individuals with MDD are well-suited to antidepressants. A potentially fruitful approach to parsing this heterogeneity is to focus on promising endophenotypes of depression, such as neuroticism, anhedonia, and cognitive control deficits. Methods Within an 8-week multisite trial of sertraline v. place...
18 CitationsSource
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#1Christian A. Webb (Harvard University)H-Index: 18
#2Colin H. Stanton (Harvard University)H-Index: 7
Last.Randy P. Auerbach (Columbia University)H-Index: 26
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#1Alexis E. Whitton (Harvard University)H-Index: 12
#2Christian A. Webb (Harvard University)H-Index: 18
Last.Diego A. Pizzagalli (Harvard University)H-Index: 60
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Abstract Background Baseline rostral anterior cingulate cortex (rACC) activity is a well-replicated nonspecific predictor of depression improvement. The rACC is a key hub of the default mode network, which prior studies indicate is hyperactive in major depressive disorder. Because default mode network downregulation is reliant on input from the salience network and frontoparietal network, an important question is whether rACC connectivity with these systems contributes to depression improvement....
3 CitationsSource
#2Robrina Walker (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
Last.Madhukar H. Trivedi (UTSW: University of Texas Southwestern Medical Center)H-Index: 91
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Abstract Background Despite the fact that higher levels of anxiety and anhedonia in Major Depressive Disorder (MDD) are linked to poorer treatment outcomes, mechanisms contributing to these clinical presentations remain unclear. Neuroticism, impaired cognitive control, and blunted reward learning may be critical processes involved in MDD and may help to explain symptoms of anxiety and anhedonia. Methods Using baseline data from patients with early-onset MDD (N=296) in the Establishing Moderators...
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#2Diego A. Pizzagalli (Harvard University)H-Index: 60
Last.Madhukar H. TrivediH-Index: 91
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Abstract The current study aimed to characterize the multifaceted nature of anxiety in patients with major depression by evaluating distinct anxiety factors. We then related these derived anxiety factors to performance on a Flanker Task of cognitive control, in order to further validate these factors. Data were collected from 195 patients with nonpsychotic chronic or recurrent major depression or dysthymic disorder. At baseline, participants completed self-report measures of anxiety, depression,...
2 CitationsSource
#1Diego A. Pizzagalli (Harvard University)H-Index: 60
#2Christian A. Webb (Harvard University)H-Index: 18
Last.Madhukar H. Trivedi (UTSW: University of Texas Southwestern Medical Center)H-Index: 91
view all 19 authors...
Importance Major depressive disorder (MDD) remains challenging to treat. Although several clinical and demographic variables have been found to predict poor antidepressant response, these markers have not been robustly replicated to warrant implementation in clinical care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity has been linked to better antidepressant outcomes. However, no prior study has evaluated whether this marker has incremental predictive validity ov...
24 CitationsSource
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