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Denisa D. Wagner
Harvard University
ImmunologyVon Willebrand factorMedicineBiologyPlatelet
361Publications
105H-index
34.3kCitations
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Publications 342
Newest
#1Siu Ling Wong (Harvard University)H-Index: 18
#2Jeremy Goverman (Shriners Hospitals for Children)H-Index: 19
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 4 authors...
Enhancing skin allograft longevity lessens the need for new allografts before optimal intervention is available. Reduced activity of ADAMTS13 (an enzyme that cleaves the pro-thrombotic and proinflammatory von Willebrand factor) and presence of neutrophil extracellular traps (NETs) have been implicated in liver and lung allograft failures. The effect of ADAMTS13 treatment and the impact of NETs on skin allografts, however, remain unexplored. Here, we adopted a murine model of complete mismatch fu...
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#1Hawa Racine Thiam (NIH: National Institutes of Health)H-Index: 1
#2Siu Ling Wong (Harvard University)H-Index: 18
Last. Clare M. Waterman (NIH: National Institutes of Health)H-Index: 35
view all 9 authors...
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones and cytotoxic proteins that are released by activated neutrophils to trap and neutralize pathogens during the innate immune response, but also form in and exacerbate sterile inflammation. Peptidylarginine deiminase 4 (PAD4) citrullinates histones and is required for NET formation (NETosis) in mouse neutrophils. While the in vivo impact of NETs is accumulating, the cellular events driving NETosis and the rol...
1 CitationsSource
#1Patrick Münzer (Harvard University)
#2Roberto Negro (Harvard University)H-Index: 1
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 13 authors...
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of disorders. We hypothesized that NLRP3 inflammasome may participate in NETosis. Using confocal microscopy, we observed the formation of ASC speck in stimulated neutrophils in the absence of infection, as well as the association of ASC speck with the released NETs. Peptidylarginine deiminase (PAD) 4, a mediator of NETosis, was needed...
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#1Deya Cherpokova (Harvard University)H-Index: 10
#2Charlotte C. Jouvene (Brigham and Women's Hospital)H-Index: 3
Last. Charles N. Serhan (Brigham and Women's Hospital)H-Index: 138
view all 9 authors...
Deep vein thrombosis (DVT) is a common cardiovascular disease with a major impact on quality of life, and safe and effective therapeutic measures to efficiently reduce existent thrombus burden are scarce. Using a comprehensive targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS)‑based metabololipidomics approach, we established temporal clusters of endogenously biosynthesized specialized pro-resolving mediators (SPMs) and proinflammatory and prothrombotic lipid mediators during DVT...
12 CitationsSource
#1Nicoletta Sorvillo (Harvard University)H-Index: 10
#2Daniella M. Mizurini (Harvard University)H-Index: 1
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 14 authors...
Rationale: PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil extracellular trap formation (NETosis), is released together with neutrophil extracellular traps into the ex...
4 CitationsSource
#1Nicoletta Sorvillo (Harvard University)H-Index: 10
#2Deya Cherpokova (Harvard University)H-Index: 10
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 4 authors...
Neutrophils play a central role in innate immune defense. Advances in neutrophil biology have brought to light the capacity of neutrophils to release their decondensed chromatin and form large extr...
5 CitationsSource
#1Clare M. Waterman (NIH: National Institutes of Health)H-Index: 35
#2Hawa Racine Thiam (NIH: National Institutes of Health)H-Index: 1
Last. Denisa D. Wagner (Boston Children's Hospital)H-Index: 105
view all 9 authors...
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones and cytotoxic proteins that are released by activated neutrophils to trap and neutralize pathogens during the innate immune response, but also form in and exacerbate sterile inflammation. Peptidylarginine deiminase 4 (PAD4) citrullinates histones and is required for NET formation (NETosis) in mouse neutrophils. While the in vivo impact of NETs is accumulating, the cellular events driving NETosis and the rol...
1 CitationsSource
#1Melanie DemersH-Index: 20
#2Georgette L. SuidanH-Index: 10
Last. Denisa D. WagnerH-Index: 105
view all 6 authors...
: Prevalence of depression is higher in patients with cancer than in the general population. Sustained systemic inflammation has been associated with depressive behavior and it has been reported that depressed patients commonly display alterations in their immune system. We previously showed that cancer in mice induces a systemic environment that promotes neutrophil activation and leukocytosis. We thus hypothesized that the peripheral systemic response to a solid tumor leads to endothelial activ...
Source
#1Nandini Krishnamoorthy (Brigham and Women's Hospital)H-Index: 15
#2David N. Douda (Brigham and Women's Hospital)H-Index: 14
Last. Bruce D. Levy (Brigham and Women's Hospital)H-Index: 57
view all 23 authors...
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Concomitant exposure of mice to an aeroallergen and endotoxin during sensitization resulted in complex neutrophilic immune responses to allergen alone during later airway challenge. Unlike allergen alone, sensitiza...
21 CitationsSource
#1Grégory FranckH-Index: 12
#2Thomas MawsonH-Index: 4
Last. K.J. LibbyH-Index: 1
view all 15 authors...
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