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K.O. Ajeigbe
Igbinedion University,Okada
25Publications
6H-index
98Citations
Publications 25
Newest
Ageratum conyzoides Linn is a medicinal plant used for diverse ethnomedicinal applications including anti-ulcer treatment. Usually, protection of gastric mucosa from injury or ulceration is dependent on the efficacy of intrinsic or induced protective factors against erosive effects of aggressive factors. In this study, our aim was to ascertain the gastroprotective activity of methanolic leaf extracts of A. conyzoides L. and assess the associated roles of gastric mucous cells and p53 protein. Thi...
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#1K.O. Ajeigbe (Igbinedion University,Okada)H-Index: 6
#2W.M. Owonikoko (Igbinedion University,Okada)
Last.G. Adeleye (Ekiti State University)
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Abstract In this biphasic study, 45 male wistar rats were divided into 9 groups. In Phase 1, Group 1 was treated with normal saline and served as the overall control, group 2 was treated with 95% Ethanol and represents the ulcer control, groups 3 and 4 received coconut water (CW; 4 ml/100 g BWt) and milk (CM; 4 ml/100 g BWt) for 4weeks while group 5 received Omeprazole (Omep; 20 mg/kg BWt) during terminal week. 95% Ethanol-induced ulceration followed the treatments in all except group 1. In the ...
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Although the gastroprotective potential of folic acid has been reported, little is known about the role of inflammation and apoptosis in the said activity. This study, therefore, assessed lipid peroxidation (LPO), Neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) as markers of inflammation and, p53 and BCl-2 as markers of apoptosis in ethanol-induced gastric ulcer pretreated with Folic acid (FA) for twenty-one (21) days. Adult male Wistar rats were arranged into experimental groups (n ...
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#1K.O. Ajeigbe (Igbinedion University,Okada)H-Index: 6
#2A.A. Onifade (UI: University of Ibadan)H-Index: 2
Last.Samuel Babafemi Olaleye (UI: University of Ibadan)H-Index: 12
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Aqueous decoction of Aspilia africana C.D Adams (Asteraceae) is an effective antiulcer agent in Southern Nigeria, but little is known about the possible underlying mechanisms. This study investigated the role of gastric acid, neutrophil infiltration and oxidative stress in the anti-ulcerogenic properties of aqueous leaf extract of Aspilia africana (ALEAA) in rats. Male albino rats were treated with 250, 500, 750 mg/kg ALEAA for 21 days. Gastric ulceration was induced by indomethacin, scored, and...
Several medicinal plants have been documented for their haematological effects either at low or high concentration but very little is known about Aspilia africana. The aim of the study was to investigate the acute effects of aqueous leaf extract of Aspilia africana at different concentrations on some haematological parameters in rats. Following 14 days of oral administration of aqueous extract of A. africana, Haematocrit (HCT), Haemoglobin concentration (HB), Mean Cell Haemoglobin Concentration ...
3 CitationsSource
#1A.A. Onifade (UI: University of Ibadan)H-Index: 1
#2K.O. Ajeigbe (College of Health Sciences, Bahrain)H-Index: 6
Last.Oladeinde Bh (College of Health Sciences, Bahrain)H-Index: 1
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World Health Organisation estimated that about 80% of Africans use herbal remedies for illness. Human immunodeficiency virus (HIV) infection which was believed to have no cure led many HIV patients to source for alternative or complementary therapy. A structured questionnaire was administered to 640 HIV patients in selected Nigerian HIV/AIDS clinics from 2009 to 2011 to assess their attitudes to the use of herbal remedy. Six hundred and ten (610) of the respondents were diagnosed by medical doct...
2 Citations
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#1Ao OlayanjuH-Index: 1
#2A. C. EzimahH-Index: 1
Last.A. J. IghodaloH-Index: 1
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The effect of differently cooked soya bean (Glycine max.) on some blood coagulation parameters was studied using forty (40) New Zealand white rabbits. The animals were grouped into four (A-D) groups of ten (10) rabbits each and fed 100% growers mash and water adlibitum for three (3) weeks. Group A (control) animals were maintained on the standard pelletized feed while group B, C and D Rabbits had 25% of their feed substituted with ‘fermented and boiled’, ‘roasted and boiled’ and ‘roasted’ soya b...
1 CitationsSource
#1A.A. OnifadeH-Index: 1
#2K.O. AjeigbeH-Index: 6
Last.Oladeinde BhH-Index: 1
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Summary: World Health Organisation estimated that about 80% of Africans use herbal remedies for illness. Human immunodeficiency virus (HIV) infection which was believed to have no cure led many HIV patients to source for alternative or complementary therapy. A structured questionnaire was administered to 640 HIV patients in selected Nigerian HIV/AIDS clinics from 2009 to 2011 to assess their attitudes to the use of herbal remedy. Six hundred and ten (610) of the respondents were diagnosed by med...
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