Thérèse Truong
French Institute of Health and Medical Research
Publications 75
#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
Last.Manjeet K. Bolla (University of Cambridge)H-Index: 27
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Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...
#1Melanie Paquet (French Institute of Health and Medical Research)
#2Nitin Shivappa (USC: University of South Carolina)H-Index: 28
Last.Thérèse Truong (French Institute of Health and Medical Research)H-Index: 23
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#1Nabila Kazmi (UoB: University of Bristol)H-Index: 3
#2Philip Haycock (UoB: University of Bristol)H-Index: 18
Last.Simon W. Lewis (UoB: University of Bristol)H-Index: 34
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Background: Prostate cancer is the second most common male cancer worldwide, but there is substantial geographical variation suggesting a potential role for modifiable risk factors in prostate carcinogenesis. Methods: We identified previously reported prostate cancer risk factors from the World Cancer Research Fund (WCRF) systematic appraisal of the global evidence (2018). We assessed whether each identified risk factor was causally associated with risk of overall (79,148 cases and 61,106 contro...
Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting...
#1Maria Escala-Garcia (NKI-AVL: Netherlands Cancer Institute)H-Index: 1
#2Qi Guo (University of Cambridge)H-Index: 8
Last.Qin Wang (University of Cambridge)H-Index: 35
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Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the prob...
#1Fredrick R. Schumacher (Case Western Reserve University)H-Index: 40
#2Fredrick Schumacher (The Royal Marsden NHS Foundation Trust)H-Index: 18
Last.Daniel Leongamornlert (ICR: Institute of Cancer Research)
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In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.