Match!
Mark H. Ginsberg
University of California, San Diego
414Publications
106H-index
41.2kCitations
Publications 414
Newest
Published on Dec 1, 2019in Acta neuropathologica communications
Janne Koskimäki2
Estimated H-index: 2
(U of C: University of Chicago),
Dongdong Zhang1
Estimated H-index: 1
(U of C: University of Chicago)
+ 26 AuthorsHussein A. Zeineddine8
Estimated H-index: 8
(U of C: University of Chicago)
Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the differences and commonalities between the transcriptomes of microdissected lesional neurovascular units (NVUs) from acute and chronic in vivo Ccm3/Pdcd10ECKO mice, and cultured brain microvascular endothelial cells (BMECs) Ccm3/Pdcd10ECKO. We identified 2409 diffe...
Published on Sep 1, 2019in Journal of Leukocyte Biology4.01
Hao Sun2
Estimated H-index: 2
(UCSD: University of California, San Diego),
Zhichao Fan (University of Connecticut Health Center)+ 3 AuthorsKlaus Ley105
Estimated H-index: 105
(UCSD: University of California, San Diego)
Published on Jun 20, 2019in JCI insight
Seán Lyne1
Estimated H-index: 1
,
Romuald Girard9
Estimated H-index: 9
+ 19 AuthorsRhonda Lightle4
Estimated H-index: 4
Published on Apr 15, 2019in Journal of Cell Biology8.89
Alexandre R. Gingras26
Estimated H-index: 26
(UCSD: University of California, San Diego),
Frederic Lagarrigue5
Estimated H-index: 5
(UCSD: University of California, San Diego)
+ 8 AuthorsWilliam B. Kiosses44
Estimated H-index: 44
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or platelets. Here, we show that talin1 F1 domain (F1) contains a previously undetected Rap1-binding site of similar affinity to that in F0. A structure-guided point mutant (R118E) in F1, which blocks Rap1 binding, abolishes the capacity of Rap1 to potent...
Published on Apr 30, 2019
Csilla Fenczik5
Estimated H-index: 5
,
Joe W. Ramos23
Estimated H-index: 23
,
Mark H. Ginsberg106
Estimated H-index: 106
Published on Mar 1, 2019in Laboratory Investigation3.68
Hussein A. Zeineddine8
Estimated H-index: 8
(U of C: University of Chicago),
Romuald Girard9
Estimated H-index: 9
(U of C: University of Chicago)
+ 19 AuthorsKenneth Avner2
Estimated H-index: 2
(U of C: University of Chicago)
Cerebral cavernous malformations (CCMs) are clusters of dilated capillaries that affect around 0.5% of the population. CCMs exist in two forms, sporadic and familial. Mutations in three documented genes, KRIT1(CCM1), CCM2, and PDCD10(CCM3), cause the autosomal dominant form of the disease, and somatic mutations in these same genes underlie lesion development in the brain. Murine models with constitutive or induced loss of respective genes have been applied to study disease pathobiology and thera...
Published on Feb 1, 2019in Stroke6.05
Janne Koskimäki2
Estimated H-index: 2
(U of C: University of Chicago),
Romuald Girard9
Estimated H-index: 9
(U of C: University of Chicago)
+ 21 AuthorsYing Cao8
Estimated H-index: 8
(U of C: University of Chicago)
Published on Jan 17, 2019in Blood16.56
Miguel Alejandro Lopez-Ramirez8
Estimated H-index: 8
(UCSD: University of California, San Diego),
Angela Pham1
Estimated H-index: 1
(UCSD: University of California, San Diego)
+ 12 AuthorsIgnacio A. Romero47
Estimated H-index: 47
(OU: Open University)
Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis of recurrent bleeding in CCM is incompletely understood. Here, we show that central nervous system hemorrhage in CCMs is associated with locally elevated expression of the anticoagulant endothelial receptors thrombomodulin (TM) and endothelial protein C receptor (EPCR). TM levels are increased in human CCM lesions, as wel...
12345678910