Match!
Mark H. Ginsberg
University of California, San Diego
479Publications
114H-index
46.2kCitations
Publications 459
Newest
#1Hao Sun (UCSD: University of California, San Diego)H-Index: 2
#2Zhichao Fan (University of Connecticut Health Center)H-Index: 11
Last.Klaus Ley (UCSD: University of California, San Diego)H-Index: 109
view all 6 authors...
1 CitationsSource
#1Janne Koskimäki (U of C: University of Chicago)H-Index: 5
#2Dongdong Zhang (U of C: University of Chicago)H-Index: 2
Last.Issam A. Awad (U of C: University of Chicago)H-Index: 69
view all 29 authors...
Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the differences and commonalities between the transcriptomes of microdissected lesional neurovascular units (NVUs) from acute and chronic in vivo Ccm3/Pdcd10ECKO mice, and cultured brain microvascular endothelial cells (BMECs) Ccm3/Pdcd10ECKO. We identified 2409 diffe...
Source
#1Hao Sun (UCSD: University of California, San Diego)H-Index: 2
#2Wun Kuk (UCSD: University of California, San Diego)
Last.Mark H. Ginsberg (UCSD: University of California, San Diego)H-Index: 114
view all 6 authors...
Abstract Background Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues (GALT), a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and murine models of intestinal inflammation. Antibody blockade of β7 integrins is generally efficacious in IBD; however, some patients fail to respond, and a few can experience exacerbations. Aims To examine the effects of loss of β7 integrin f...
Source
#1Mark H. Ginsberg (UCSD: University of California, San Diego)H-Index: 114
Source
#1Bart Weijts (UCSD: University of California, San Diego)H-Index: 9
#2Iftach Shaked (UCSD: University of California, San Diego)
Last.David Traver (UCSD: University of California, San Diego)H-Index: 51
view all 6 authors...
Lumenization of de novo formed blood vessels occurs either through cell hollowing (intracellular lumen) or cord hollowing (extracellular lumen) and restricts thereby the initial lumen diameter to one or two endothelial cells (ECs) respectively. However, vasculogenesis can result in large diameter blood vessels, raising the question how these vessels are formed. Here, we describe an alternative model of vasculogenesis that results in the formation of large diameter vessels. In this model, ECs coa...
Source
#1Seán B. LyneH-Index: 3
#2Romuald GirardH-Index: 11
Last.Issam A. AwadH-Index: 69
view all 22 authors...
1 CitationsSource
#1Alexandre R. Gingras (UCSD: University of California, San Diego)H-Index: 26
#2Frederic Lagarrigue (UCSD: University of California, San Diego)H-Index: 5
Last.Mark H. Ginsberg (UCSD: University of California, San Diego)H-Index: 114
view all 11 authors...
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or platelets. Here, we show that talin1 F1 domain (F1) contains a previously undetected Rap1-binding site of similar affinity to that in F0. A structure-guided point mutant (R118E) in F1, which blocks Rap1 binding, abolishes the capacity of Rap1 to potent...
Source
#1Csilla A. FenczikH-Index: 6
#2Joe W. RamosH-Index: 24
Last.Mark H. GinsbergH-Index: 114
view all 3 authors...
Source
#1Hussein A. Zeineddine (U of C: University of Chicago)H-Index: 8
#2Romuald Girard (U of C: University of Chicago)H-Index: 11
Last.Issam A. Awad (U of C: University of Chicago)H-Index: 69
view all 22 authors...
Cerebral cavernous malformations (CCMs) are clusters of dilated capillaries that affect around 0.5% of the population. CCMs exist in two forms, sporadic and familial. Mutations in three documented genes, KRIT1(CCM1), CCM2, and PDCD10(CCM3), cause the autosomal dominant form of the disease, and somatic mutations in these same genes underlie lesion development in the brain. Murine models with constitutive or induced loss of respective genes have been applied to study disease pathobiology and thera...
4 CitationsSource
#1Janne KoskimäkiH-Index: 5
#2Romuald GirardH-Index: 11
Last.Issam A. AwadH-Index: 69
view all 29 authors...
5 CitationsSource
12345678910