Colin T. Pease
Leeds Teaching Hospitals NHS Trust
Physical therapyRheumatologyImmunologyPolymyalgia rheumaticaMedicine
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Publications 104
#1Jessica R Tarn (Newcastle University)H-Index: 1
#2Nadia Howard-Tripp (Newcastle University)H-Index: 1
Last. Paul AllcoaH-Index: 1
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Summary Background Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjogren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response. Methods We did hierarchical cluster analysis using five common symptoms associated with primary Sjogren's syndrome (pain, fatigue, dryness, anxiety, and depression), followed by mul...
2 CitationsSource
#1Kate Hackett (Northumbria University)H-Index: 2
#2Kristen Davies (Newcastle University)H-Index: 1
Last. Wan-Fai NgH-Index: 2
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Objectives To report on fatigue in patients from the United Kingdom primary Sjogren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness. Methods From our cohort (n = 608), we identified those with comorbidities associated with fatigue, and those taking medications associated with drowsiness. We constructed dummy variables, permitting the contribution of these potentially assignable ...
#1Sayam Dubash (Leeds Teaching Hospitals NHS Trust)H-Index: 3
#2Colin T. Pease (Leeds Teaching Hospitals NHS Trust)H-Index: 32
Last. Helena Marzo-Ortega (Leeds Teaching Hospitals NHS Trust)H-Index: 16
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Sacroiliitis is associated with the spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, and reactive arthritis (ReA), and may be visualized using magnetic resonance imaging (MRI). Here, we describe 4 cases of acute unilateral sacroiliitis with florid MRI appearances that mimicked infection but demonstrated a prompt and complete response to nonsteroidal antiinflammatory drugs (NSAID).
#1Dennis LendremH-Index: 19
#2Jessica TarnH-Index: 6
Last. Wan-Fai NgH-Index: 27
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#1Benjamin A. FisherH-Index: 16
#2Colin C Everett (University of Leeds)H-Index: 11
Last. Simon J. BowmanH-Index: 32
view all 27 authors...
Objectives To compare the effects of rituximab versus placebo on salivary gland ultrasound (SGUS) in primary Sjogren’s syndrome (PSS) in a multicentre, multiobserver phase III trial substudy. Methods Subjects consenting to SGUS were randomised to rituximab or placebo given at weeks 0, 2, 24 and 26, and scanned at baseline and weeks 16 and 48. Sonographers completed a 0–11 total ultrasound score (TUS) comprising domains of echogenicity, homogeneity, glandular definition, glands involved and hypoe...
15 CitationsSource
#1Alexandre Dumusc (UNIL: University of Lausanne)H-Index: 5
#2Wan-Fai Ng (Newcastle University)H-Index: 27
Last. Simon J. BowmanH-Index: 32
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OBJECTIVES: To assess the use of the Clinical EULAR Sjogren's Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with primary Sjogren's syndrome (pSS), according to the new ACR-EULAR classification criteria, from the UK Primary Sjogren's Syndrome Registry (UKPSSR). METHODS: A total of 665 patients from the UKPSSR cohort were analysed at their time of inclusion in the...
1 CitationsSource
#1Clare OniH-Index: 1
#2Sheryl MitchellH-Index: 11
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#1Om Bezzina (Newcastle University)H-Index: 1
#2Peter Gallagher (Newcastle University)H-Index: 33
Last. Lucy J. Robinson (Newcastle University)H-Index: 11
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Supported by the Medical Research Council (G0800629), the British Sjogren's Syndrome Association, and the National Institute for Health Research Newcastle Biomedical Research Centre on Ageing & Chronic Diseases.
6 CitationsSource
#1Simon J. Bowman (University Hospitals Birmingham NHS Foundation Trust)H-Index: 32
#2Colin C Everett (University of Leeds)H-Index: 11
Last. Michele Bombardieri (QMUL: Queen Mary University of London)H-Index: 36
view all 23 authors...
Objective: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjogren's Syndrome (PSS). Methods: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo I...
50 CitationsSource
#1Ba FisherH-Index: 2
#2Colin C EverettH-Index: 11
Last. S. BowmanH-Index: 13
view all 25 authors...