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Paul J. Simpson
University of Michigan
32Publications
15H-index
2,100Citations
Publications 29
Newest
#1Masaru Minami (HSUH: Health Sciences University of Hokkaido)H-Index: 22
#2Edward M. Driscoll (UM: University of Michigan)H-Index: 18
Last.Benedict R. Lucchesi (UM: University of Michigan)H-Index: 64
view all 5 authors...
This study was performed to assess the effect of BMY21190, an inhibitor of cAMP phosphodiesterase, on infarct size using a canine ischemic model that underwent a 90-min occlusion and a 6-hour reperfus
3 CitationsSource
Summary We tested the hypothesis that opening myocardial ATP-dependent K + (ATP-K) channels by administration of (-)-pinacidil or (-)-3-pyridyl pinacidil intracoronarily (i.e.) either during ischemia or as pretreatment could decrease infarct size in a canine model of ischemia-reperfusion injury in anesthetized male hounds subjected to 90-min left circumflex coronary artery (LCX) occlusion followed by 5-h reperfusion. Drugs were administered by one of two protocols. In the postocclusion treatment...
6 CitationsSource
The purpose of this study was to determine whether the selective type IV cAMP-phosphodiesterase inhibitor rolipram could reduce the reperfusion injury that occurs during myocardial infarction in the anesthetized dog. This question was tested in pentobarbital-anesthetized dogs subject to 90 min of regional myocardial ischemia and 5 h of reperfusion. Dogs were treated with 1 mg/kg of rolipram (i.v., 15 min before reperfusion) followed by a 1 mg/kg/h infusion over the duration of the 5 h of reperfu...
10 CitationsSource
The potential protective effects of serotonin receptor antagonism during the process of acute myocardial infarction were studied in anesthetized male dogs, which were subjected to a 90-min left circumflex coronary artery occlusion followed by 5 h of reperfusion. Either vehicle (0.9% NaCl) or the serotonin (5HT2) receptor antagonist LY53857 was infused i.v. at a dose of 0.5 mg/kg, followed by a constant infusion of 2 mg/kg/min beginning 5 min before left circumflex coronary artery occlusion and c...
12 Citations
#1Judith K. Mickelson (UM: University of Michigan)H-Index: 17
#2Paul J. Simpson (UM: University of Michigan)H-Index: 15
Last.Benedict R. Lucchesi (UM: University of Michigan)H-Index: 64
view all 7 authors...
Coronary artery rethrombosis can complicate initially effective thrombolytic therapy. Platelets interacting with injured vascular endothelium in a region along the coronary artery with reduced luminal cross-sectional area contribute to rethrombosis. The purpose of this study was to investigate the potential of the F(ab')2 fragment of the murine monoclonal antibody 7E3 [7E3 F(ab')2] to prevent rethrombosis after intracoronary clot lysis with recombinant tissue-type plasminogen activator (rt-PA) i...
80 CitationsSource
#1Robert F. ToddH-Index: 16
#2Paul J. SimpsonH-Index: 15
Last.Benedict R. LucchesiH-Index: 64
view all 3 authors...
Mol is a heterodimeric glycoprotein (gp 155,95) expressed on the plasma membrane of neutrophils (PMN), monocytes and certain macrophages, and a subset of large granular lymphoid cells (reviewed in 1). The identification and characterization of Mol was made possible by the generation of monoclonal antibodies specific for epitopes expressed on the higher molecular weight α-subunit or the lower molecular weight β-subunit. According to World Health Organization (WHO) nomenclature, antibodies recogni...
Source
#1Paul J. Simpson (UM: University of Michigan)H-Index: 15
#2rd R F Todd (UM: University of Michigan)H-Index: 11
Last.Benedict R. Lucchesi (UM: University of Michigan)H-Index: 64
view all 9 authors...
Pentobarbital anesthetized dogs were subjected to 90 minutes of left circumflex coronary artery (LCCA) occlusion followed by 72 hours of reperfusion. Control or anti-Mo1 (904) F(ab')2 fragments of monoclonal antibodies were administered intravenously at a dose of 1 mg/kg beginning 45 minutes after occlusion and at a dose of 0.5 mg/kg at 12, 24, 36, and 48 hours after reperfusion. Myocardial infarct size expressed as a percentage of the area at risk (IN/AR) measured postmortem after 72 hours of r...
130 CitationsSource
#1R J Schott (UM: University of Michigan)H-Index: 8
#2B S Nao (SHM: Society of Hospital Medicine)H-Index: 2
Last.Kim P. Gallagher (UM: University of Michigan)H-Index: 33
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To determine if inhibition of leukocyte adhesion and aggregation could improve postischemic ventricular dysfunction ("stunning"), a monoclonal antibody (904) that binds to the adhesion-promoting Mo1 glycoprotein on the cell surface of leukocytes was administered intravenously (0.5 mg/kg) to open-chest dogs before a 15-minute coronary occlusion. Ultrasonic crystals placed in ischemic and control myocardium were used to measure systolic wall thickening during a 15-minute occlusion of the left ante...
21 CitationsSource
#1Judith K. MickelsonH-Index: 17
#2Paul J. Simpson (UM: University of Michigan)H-Index: 15
Last.Mark J. McGillem (UM: University of Michigan)H-Index: 9
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Streptokinase is an effective thrombolytic agent which, with early restoration of coronary blood flow, has the potential for limiting infarct size. Distinct from thrombolysis, we studied the effects of streptokinase on reperfusion coronary blood flow and infarct size. Open-chest anesthetized canines underwent a 90 minute snare occlusion of the left circumflex coronary artery followed by release and reperfusion through a critical stenosis for 6 hours. The animals were assigned randomly to two gro...
3 CitationsSource
#1Judith K. Mickelson (UM: University of Michigan)H-Index: 17
#2Paul J. Simpson (UM: University of Michigan)H-Index: 15
Last.Benedict R. Lucchesi (UM: University of Michigan)H-Index: 64
view all 3 authors...
with direct current induced intimal injury (100 PA for 5 h) and critical stenosis of the left circumflex coronary artery (LCCA). Baseline LCCA blood flow (CBF) was similar in 7E3 F(ab’), and control groups, but decreased in the controls [24 + 2 ml/min to 0 + 0 ml/min, n = 13 (mean ~s.E.M.)] due to thrombotic occlusion in each case (time to thrombosis 136 f 15 min). In the group treated with 7E3 F(ab’),, CBF did not change significantly (27 + 3 ml/min to 22 k 3 ml/min, a = 6) and thrombotic occlu...
48 CitationsSource
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