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Paul J. Simpson
University of Michigan
30Publications
15H-index
1,948Citations
Publications 30
Newest
Published on Sep 13, 2019in Circulation Research15.86
Bat-Erdene Myagmar6
Estimated H-index: 6
,
Taylor Ismaili (Janssen Pharmaceutica)+ 6 AuthorsPaul J. Simpson15
Estimated H-index: 15
(UCSF: University of California, San Francisco)
Rationale: Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. Objective: T...
Published on Jan 1, 1995in Pharmacology1.61
Masaru Minami23
Estimated H-index: 23
(HSUH: Health Sciences University of Hokkaido),
Edward M. Driscoll18
Estimated H-index: 18
(UM: University of Michigan)
+ 2 AuthorsBenedict R. Lucchesi62
Estimated H-index: 62
(UM: University of Michigan)
This study was performed to assess the effect of BMY21190, an inhibitor of cAMP phosphodiesterase, on infarct size using a canine ischemic model that underwent a 90-min occlusion and a 6-hour reperfus
Published on Nov 1, 1993in Journal of Cardiovascular Pharmacology2.37
Jeffrey K. Smallwood10
Estimated H-index: 10
,
Judith A. Schelm3
Estimated H-index: 3
+ 1 AuthorsPaul J. Simpson15
Estimated H-index: 15
Summary We tested the hypothesis that opening myocardial ATP-dependent K + (ATP-K) channels by administration of (-)-pinacidil or (-)-3-pyridyl pinacidil intracoronarily (i.e.) either during ischemia or as pretreatment could decrease infarct size in a canine model of ischemia-reperfusion injury in anesthetized male hounds subjected to 90-min left circumflex coronary artery (LCX) occlusion followed by 5-h reperfusion. Drugs were administered by one of two protocols. In the postocclusion treatment...
Published on Jun 1, 1992in Journal of Cardiovascular Pharmacology2.37
Paul J. Simpson15
Estimated H-index: 15
,
Judith A. Schelm3
Estimated H-index: 3
+ 2 AuthorsTerry D. Lindstrom13
Estimated H-index: 13
The purpose of this study was to determine whether the selective type IV cAMP-phosphodiesterase inhibitor rolipram could reduce the reperfusion injury that occurs during myocardial infarction in the anesthetized dog. This question was tested in pentobarbital-anesthetized dogs subject to 90 min of regional myocardial ischemia and 5 h of reperfusion. Dogs were treated with 1 mg/kg of rolipram (i.v., 15 min before reperfusion) followed by a 1 mg/kg/h infusion over the duration of the 5 h of reperfu...
Published on Sep 1, 1991in Journal of Pharmacology and Experimental Therapeutics3.62
Paul J. Simpson15
Estimated H-index: 15
,
Judith A. Schelm3
Estimated H-index: 3
+ 1 AuthorsJeffrey K. Smallwood10
Estimated H-index: 10
The potential protective effects of serotonin receptor antagonism during the process of acute myocardial infarction were studied in anesthetized male dogs, which were subjected to a 90-min left circumflex coronary artery occlusion followed by 5 h of reperfusion. Either vehicle (0.9% NaCl) or the serotonin (5HT2) receptor antagonist LY53857 was infused i.v. at a dose of 0.5 mg/kg, followed by a constant infusion of 2 mg/kg/min beginning 5 min before left circumflex coronary artery occlusion and c...
Published on Feb 1, 1990in Circulation23.05
Judith K. Mickelson17
Estimated H-index: 17
(UM: University of Michigan),
Paul J. Simpson15
Estimated H-index: 15
(UM: University of Michigan)
+ 4 AuthorsBenedict R. Lucchesi62
Estimated H-index: 62
(UM: University of Michigan)
Coronary artery rethrombosis can complicate initially effective thrombolytic therapy. Platelets interacting with injured vascular endothelium in a region along the coronary artery with reduced luminal cross-sectional area contribute to rethrombosis. The purpose of this study was to investigate the potential of the F(ab')2 fragment of the murine monoclonal antibody 7E3 [7E3 F(ab')2] to prevent rethrombosis after intracoronary clot lysis with recombinant tissue-type plasminogen activator (rt-PA) i...
Published on Jan 1, 1990
Robert F. Todd16
Estimated H-index: 16
,
Paul J. Simpson15
Estimated H-index: 15
,
Benedict R. Lucchesi62
Estimated H-index: 62
Mol is a heterodimeric glycoprotein (gp 155,95) expressed on the plasma membrane of neutrophils (PMN), monocytes and certain macrophages, and a subset of large granular lymphoid cells (reviewed in 1). The identification and characterization of Mol was made possible by the generation of monoclonal antibodies specific for epitopes expressed on the higher molecular weight α-subunit or the lower molecular weight β-subunit. According to World Health Organization (WHO) nomenclature, antibodies recogni...
Published on Jan 1, 1990in Circulation23.05
Paul J. Simpson15
Estimated H-index: 15
(UM: University of Michigan),
R. F. Todd16
Estimated H-index: 16
(UM: University of Michigan)
+ 6 AuthorsBenedict R. Lucchesi62
Estimated H-index: 62
(UM: University of Michigan)
Pentobarbital anesthetized dogs were subjected to 90 minutes of left circumflex coronary artery (LCCA) occlusion followed by 72 hours of reperfusion. Control or anti-Mo1 (904) F(ab')2 fragments of monoclonal antibodies were administered intravenously at a dose of 1 mg/kg beginning 45 minutes after occlusion and at a dose of 0.5 mg/kg at 12, 24, 36, and 48 hours after reperfusion. Myocardial infarct size expressed as a percentage of the area at risk (IN/AR) measured postmortem after 72 hours of r...
Published on Oct 1, 1989in Circulation Research15.86
Robert J. Schott8
Estimated H-index: 8
(UM: University of Michigan),
B S Nao2
Estimated H-index: 2
(SHM: Society of Hospital Medicine)
+ 4 AuthorsKim P. Gallagher32
Estimated H-index: 32
(UM: University of Michigan)
To determine if inhibition of leukocyte adhesion and aggregation could improve postischemic ventricular dysfunction ("stunning"), a monoclonal antibody (904) that binds to the adhesion-promoting Mo1 glycoprotein on the cell surface of leukocytes was administered intravenously (0.5 mg/kg) to open-chest dogs before a 15-minute coronary occlusion. Ultrasonic crystals placed in ischemic and control myocardium were used to measure systolic wall thickening during a 15-minute occlusion of the left ante...
Published on Jun 1, 1989in International Journal of Cardiology3.47
Judith K. Mickelson17
Estimated H-index: 17
,
Paul J. Simpson15
Estimated H-index: 15
(UM: University of Michigan)
+ 4 AuthorsMark J. McGillem9
Estimated H-index: 9
(UM: University of Michigan)
Streptokinase is an effective thrombolytic agent which, with early restoration of coronary blood flow, has the potential for limiting infarct size. Distinct from thrombolysis, we studied the effects of streptokinase on reperfusion coronary blood flow and infarct size. Open-chest anesthetized canines underwent a 90 minute snare occlusion of the left circumflex coronary artery followed by release and reperfusion through a critical stenosis for 6 hours. The animals were assigned randomly to two gro...
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