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Maria A. Rocca
Vita-Salute San Raffaele University
PathologyMagnetic resonance imagingPhysical therapyMultiple sclerosisMedicine
636Publications
71H-index
18kCitations
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Publications 649
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#1Svenja Kiljan (VUmc: VU University Medical Center)
#2P Preziosa (VUmc: VU University Medical Center)H-Index: 1
Last. Jeroen J. G. Geurts (VUmc: VU University Medical Center)H-Index: 58
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BACKGROUND: Neuroaxonal degeneration is one of the hallmarks of clinical deterioration in progressive multiple sclerosis (PMS). OBJECTIVE: To elucidate the association between neuroaxonal degeneration and both local cortical and connected white matter (WM) tract pathology in PMS. METHODS: Post-mortem in situ 3T magnetic resonance imaging (MRI) and cortical tissue blocks were collected from 16 PMS donors and 10 controls. Cortical neuroaxonal, myelin, and microglia densities were quantified histop...
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#1Maria A. RoccaH-Index: 71
#2Laura Cacciaguerra (UniSR: Vita-Salute San Raffaele University)H-Index: 1
Last. Massimo FilippiH-Index: 118
view all 3 authors...
Introduction. With the advent of targeted drugs, a correct identification of patients with neuromyelitis optica spectrum disorders (NMOSD) is fundamental. Moreover, to assess treatment efficacy, se...
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#1Paolo PreziosaH-Index: 15
#2Maria A. RoccaH-Index: 71
Last. Massimo FilippiH-Index: 118
view all 3 authors...
Introduction: Neurodegenerative processes occur from the beginning of multiple sclerosis, contribute to irreversible clinical disability and are only partially addressed by current disease-modifyin...
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Here, we explored trajectories of sub-regional thalamic resting state (RS) functional connectivity (FC) modifications occurring in clinically isolated syndrome (CIS) patients early after their first clinical episode, and assessed their relationship with disability over 7 years. RS fMRI and clinical data were prospectively acquired from 59 CIS patients and 13 healthy controls (HC) over 2 years. A clinical re-assessment was performed in 53 (89%) patients after 7 years. Using a structural connectiv...
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#1James H. ColeH-Index: 23
#2Joel Raffel (Imperial College London)H-Index: 6
Last. Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
view all 21 authors...
OBJECTIVE: During the natural course of MS, the brain is exposed to ageing as well as disease effects. Brain ageing can be modelled statistically; the so-called 'brain-age' paradigm. Here, we evaluated whether brain-predicted age difference (brain-PAD) was sensitive to the presence of MS, clinical progression and future outcomes. METHODS: In a longitudinal, multi-centre sample of 3,565 MRI scans, in 1,204 MS and clinically-isolated syndrome (CIS) patients and 150 healthy controls (mean follow-up...
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#1Maria A. RoccaH-Index: 71
#2Paolo PreziosaH-Index: 15
Last. Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
view all 3 authors...
AbstractIntroduction. In multiple sclerosis (MS), inflammatory, demyelinating and neurodegenerative phenomena affect the spinal cord, with detrimental effects on patients’ clinical disability. Alth...
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#1Roberta MessinaH-Index: 9
#2Maria A. RoccaH-Index: 71
Last. Massimo FilippiH-Index: 118
view all 7 authors...
Resting state (RS) functional connectivity (FC) abnormalities of brain networks involved in pain- and multisensory processing have been disclosed in adult-migraine patients. We explored RS FC of large-scale brain networks in pediatric-migraine patients and their correlation with patients’ clinical characteristics. RS functional MRI data was acquired from 13 pediatric-migraine patients and 14 age- and sex-matched controls. Intra- and inter-network RS FC differences between patients and controls w...
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Objective To compare the efficacy of fingolimod and natalizumab in preventing regional grey matter (GM) and white matter (WM) atrophy in relapsing-remitting multiple sclerosis (RRMS) over 2 years. Methods Patients with RRMS starting fingolimod (n=25) or natalizumab (n=30) underwent clinical examination and 3T MRI scans at baseline (month (M) 0), M6, M12 and M24. Seventeen healthy controls were also scanned at M0 and M24. Tensor-based morphometry and SPM12 were used to assess the longitudinal reg...
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#1Jaume Sastre-Garriga (Autonomous University of Barcelona)H-Index: 40
#3Deborah Pareto (Autonomous University of Barcelona)H-Index: 12
Last. Frederik Barkhof (NIHR: National Institute for Health Research)H-Index: 111
view all 21 authors...
Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used clinically to assess the inflammatory component of the disease, particularly the presence and evolution of focal lesions — the pathological hallmark of MS. However, diffuse neurodegenerative processes that are at least partly independent of inflammat...
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