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Su Yang
Emory University
18Publications
9H-index
261Citations
Publications 18
Newest
Published on Jun 1, 2019in Acta Neuropathologica18.17
Peng Yin1
Estimated H-index: 1
(JNU: Jinan University),
Xiangyu Guo9
Estimated H-index: 9
(JNU: Jinan University)
+ 7 AuthorsXiao-Jiang Li1
Estimated H-index: 1
(JNU: Jinan University)
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in the brains of rhesus monkeys and mice, we verified that mutant TDP-43 is distributed in the cytoplasm of the monkey brain and that the majority o...
Published on Apr 1, 2019in Cell Research17.85
Weili Yang9
Estimated H-index: 9
(JNU: Jinan University),
Yunbo Liu1
Estimated H-index: 1
(Peking Union Medical College)
+ 12 AuthorsZhengyi Yang14
Estimated H-index: 14
(CAS: Chinese Academy of Sciences)
Published on Dec 1, 2018in Cell Reports7.82
Su Yang9
Estimated H-index: 9
(Emory University),
Li Shihua76
Estimated H-index: 76
(Emory University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Summary Virus-mediated expression of CRISPR/Cas9 is commonly used for genome editing in animal brains to model or treat neurological diseases, but the potential neurotoxicity of overexpressing bacterial Cas9 in the mammalian brain remains unknown. Through RNA sequencing (RNA-seq) analysis, we find that virus-mediated expression of Cas9 influences the expression of genes involved in neuronal functions. Reducing the half-life of Cas9 by tagging with geminin, whose expression is regulated by the ce...
Published on Dec 1, 2018in Molecular Neurodegeneration8.27
Jifeng Guo4
Estimated H-index: 4
(CSU: Central South University),
Yiting Cui3
Estimated H-index: 3
(CSU: Central South University)
+ 8 AuthorsSu Yang9
Estimated H-index: 9
(Emory University)
Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar Purkinje neurons. Currently there is no effective treatment for SCA17. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expres...
Published on Nov 29, 2018in Frontiers in Physiology3.20
Su Yang9
Estimated H-index: 9
(Emory University),
Li Shihua76
Estimated H-index: 76
(JNU: Jinan University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a c...
Published on May 1, 2018in Cell36.22
Sen Yan11
Estimated H-index: 11
(JNU: Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
Published on Dec 1, 2017in Nature Communications11.88
Su Yang9
Estimated H-index: 9
(Emory University),
Huiming Yang3
Estimated H-index: 3
(CSU: Central South University)
+ 7 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Emory University)
The hypothalamus has a vital role in controlling food intake and energy homeostasis; its activity is modulated by neuropeptides and endocrine factors. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is also localized in the endoplasmic reticulum (ER) in neurons. Here we show that MANF is highly enriched in distinct nuclei of the mouse hypothalamus, and that MANF expression in the hypothalamus is upregulated in response to fasting. Increasing or decreasing...
Published on Sep 20, 2017in The Journal of Neuroscience6.07
Yang Yang3
Estimated H-index: 3
(CSU: Central South University),
Su Yang9
Estimated H-index: 9
(Emory University)
+ 4 AuthorsLi Shihua76
Estimated H-index: 76
(CSU: Central South University)
Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. Although previous studies have demonstrated that expression of polyQ-expanded proteins in glial cells can cause neuronal injury via noncell-autonomous mechanisms, these studies investigated animal models that overexpress transgenic mutant proteins. Sinc...
Published on Aug 1, 2017in Journal of Neuroscience Research4.14
Yiting Cui3
Estimated H-index: 3
(CSU: Central South University),
Su Yang9
Estimated H-index: 9
(Emory University)
+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Spinocerebellar ataxia type 17 (SCA17) is a type of autosomal dominant cerebellar ataxia (ADCA) characterized by variable manifestations, including cerebellar ataxia, dementia, and psychiatric symptoms. Since the identification of a CAG repeat expansion in the TATA-box binding protein (TBP) gene in a patient with ataxia in 1999 and then verification of this expansion in patients with SCA17 in 2001, several SCA17 rodent models, including both knock-in and transgenic models in mice and rats, have ...
Published on Jun 19, 2017in Frontiers in Aging Neuroscience3.63
Hui-Ming Yang1
Estimated H-index: 1
(CSU: Central South University),
Su Yang9
Estimated H-index: 9
(Emory University)
+ 2 AuthorsJifeng Guo4
Estimated H-index: 4
Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (> 36) in exon 1 of HTT gene that encodes huntingtin protein. Although HD is characterized by a predominant loss of neurons in the striatum and cortex, previous studies point to a critical role of aberrant accumulation of mutant huntingtin in microglia that contributes to the progressive neurodegeneration in HD, through both cell-autonomous and non-cell-autonomou...
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