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Su Yang
Emory University
17Publications
9H-index
351Citations
Publications 17
Newest
#1Peng Yin (JNU: Jinan University)H-Index: 1
#2Xiangyu Guo (JNU: Jinan University)H-Index: 3
Last.Xiao-Jiang Li (JNU: Jinan University)H-Index: 1
view all 10 authors...
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in the brains of rhesus monkeys and mice, we verified that mutant TDP-43 is distributed in the cytoplasm of the monkey brain and that the majority o...
3 CitationsSource
#1Weili Yang (JNU: Jinan University)H-Index: 9
#2Yunbo Liu (Peking Union Medical College)H-Index: 2
Last.Xiao-Jiang Li (Emory University)H-Index: 62
view all 15 authors...
6 CitationsSource
#1Su Yang (Emory University)H-Index: 9
#2Li Shihua (Emory University)H-Index: 83
Last.Xiao-Jiang Li (Emory University)H-Index: 62
view all 3 authors...
Summary Virus-mediated expression of CRISPR/Cas9 is commonly used for genome editing in animal brains to model or treat neurological diseases, but the potential neurotoxicity of overexpressing bacterial Cas9 in the mammalian brain remains unknown. Through RNA sequencing (RNA-seq) analysis, we find that virus-mediated expression of Cas9 influences the expression of genes involved in neuronal functions. Reducing the half-life of Cas9 by tagging with geminin, whose expression is regulated by the ce...
4 CitationsSource
#1Jifeng Guo (CSU: Central South University)H-Index: 18
#2Yiting Cui (CSU: Central South University)H-Index: 3
Last.Li Shihua (CSU: Central South University)H-Index: 83
view all 11 authors...
Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar Purkinje neurons. Currently there is no effective treatment for SCA17. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expres...
9 CitationsSource
#1Su Yang (Emory University)H-Index: 9
#2Li Shihua (JNU: Jinan University)H-Index: 83
Last.Xiao-Jiang Li (Emory University)H-Index: 62
view all 3 authors...
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a c...
Source
#1Sen Yan (JNU: Jinan University)H-Index: 8
#2Zhuchi Tu (JNU: Jinan University)H-Index: 7
Last.Xiao-Jiang Li (Emory University)H-Index: 62
view all 21 authors...
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
44 CitationsSource
#1Su Yang (Emory University)H-Index: 9
#2Huiming Yang (CSU: Central South University)H-Index: 3
Last.Xiao-Jiang Li (Emory University)H-Index: 62
view all 10 authors...
The hypothalamus has a vital role in controlling food intake and energy homeostasis; its activity is modulated by neuropeptides and endocrine factors. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is also localized in the endoplasmic reticulum (ER) in neurons. Here we show that MANF is highly enriched in distinct nuclei of the mouse hypothalamus, and that MANF expression in the hypothalamus is upregulated in response to fasting. Increasing or decreasing...
14 CitationsSource
#1Yang Yang (CSU: Central South University)H-Index: 3
#2Su Yang (Emory University)H-Index: 9
Last.Li Shihua (CSU: Central South University)H-Index: 83
view all 7 authors...
Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. Although previous studies have demonstrated that expression of polyQ-expanded proteins in glial cells can cause neuronal injury via noncell-autonomous mechanisms, these studies investigated animal models that overexpress transgenic mutant proteins. Sinc...
7 CitationsSource
#1Yiting Cui (CSU: Central South University)H-Index: 3
#2Su Yang (Emory University)H-Index: 9
Last.Li Shihua (Emory University)H-Index: 83
view all 4 authors...
Spinocerebellar ataxia type 17 (SCA17) is a type of autosomal dominant cerebellar ataxia (ADCA) characterized by variable manifestations, including cerebellar ataxia, dementia, and psychiatric symptoms. Since the identification of a CAG repeat expansion in the TATA-box binding protein (TBP) gene in a patient with ataxia in 1999 and then verification of this expansion in patients with SCA17 in 2001, several SCA17 rodent models, including both knock-in and transgenic models in mice and rats, have ...
4 CitationsSource
#1Hui-Ming Yang (CSU: Central South University)H-Index: 1
#2Su Yang (Emory University)H-Index: 9
Last.Jifeng GuoH-Index: 18
view all 5 authors...
Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (> 36) in exon 1 of HTT gene that encodes huntingtin protein. Although HD is characterized by a predominant loss of neurons in the striatum and cortex, previous studies point to a critical role of aberrant accumulation of mutant huntingtin in microglia that contributes to the progressive neurodegeneration in HD, through both cell-autonomous and non-cell-autonomou...
19 CitationsSource
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