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Holger Schulze
University of Erlangen-Nuremberg
PsychologyNeuroscienceTinnitusAuditory cortexAudiology
78Publications
16H-index
802Citations
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Publications 83
Newest
#1Marcus Jeschke (Leibniz Institute for Neurobiology)H-Index: 8
#2PD Dr. Max F.K. Happel (Leibniz Institute for Neurobiology)
Last. Frank W. Ohl (Leibniz Institute for Neurobiology)H-Index: 30
view all 7 authors...
Harmful environmental sounds are a prevailing source for chronic hearing impairments, including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are related to pathophysiological damage to the sensory receptor epithelia and its effects along the auditory pathway, such as functional reorganizations in the auditory cortex (ACx), have been documented in numerous studies. An open question concerns the temporal evolution of maladaptive changes after damage and their manifestat...
Source
#1Marlen DierichH-Index: 2
#2Stephanie Hartmann (FAU: University of Erlangen-Nuremberg)H-Index: 4
Last. Tobias Huth (FAU: University of Erlangen-Nuremberg)H-Index: 10
view all 20 authors...
Cleavage of amyloid precursor protein (APP) by β-secretase BACE1 initiates the production and accumulation of neurotoxic amyloid-β peptides, which is widely considered an essential pathogenic mechanism in Alzheimer9s disease (AD). Here, we report that BACE1 is essential for normal auditory function. Compared to wild type littermates, BACE1-/- mice of either sex exhibit significant hearing deficits, as indicated by increased thresholds and reduced amplitudes in auditory brainstem responses (ABRs)...
Source
#1Lisa Klotz (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Olaf Wendler (FAU: University of Erlangen-Nuremberg)H-Index: 15
Last. Ralf Enz (FAU: University of Erlangen-Nuremberg)H-Index: 15
view all 6 authors...
Glutamate is the major excitatory neurotransmitter in the CNS binding to a variety of glutamate receptors. Metabotropic glutamate receptors (mGluR1 to mGluR8) can act excitatory or inhibitory, depe...
1 CitationsSource
#1Achim SchillingH-Index: 6
#2Patrick KraussH-Index: 6
Last. Holger SchulzeH-Index: 16
view all 4 authors...
Source
#1Richard Gerum (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Hinrich Rahlfs (FAU: University of Erlangen-Nuremberg)
Last. Achim Schilling (FAU: University of Erlangen-Nuremberg)H-Index: 6
view all 11 authors...
The modulation of the acoustic startle reflex (ASR) by a pre-stimulus called pre-pulse inhibition (PPI, for gap of silence pre-stimulus: GPIAS) is a versatile tool to, e.g. estimate hearing thresholds or identify subjective tinnitus percepts in rodents. A proper application of these paradigms depends on a reliable measurement of the ASR amplitudes and an exact stimulus presentation in terms of frequency and intensity. Here, we introduce a novel open-source solution for the construction of a low-...
Source
#1Achim SchillingH-Index: 6
#2Claus MetznerH-Index: 11
Last. Patrick KraussH-Index: 6
view all 6 authors...
Deep neural networks typically outperform more traditional machine learning models in their ability to classify complex data, and yet is not clear how the individual hidden layers of a deep network contribute to the overall classification performance. We thus introduce a Generalized Discrimination Value (GDV) that measures, in a non-invasive manner, how well different data classes separate in each given network layer. The GDV can be used for the automatic tuning of hyper-parameters, such as the ...
#1Birgit Mazurek (Charité)H-Index: 24
#2Marlies Knipper (University of Tübingen)H-Index: 43
Last. Holger Schulze (FAU: University of Erlangen-Nuremberg)H-Index: 16
view all 4 authors...
Source
#1Achim Schilling (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Richard Gerum (FAU: University of Erlangen-Nuremberg)H-Index: 6
Last. Holger Schulze (FAU: University of Erlangen-Nuremberg)H-Index: 16
view all 6 authors...
Reliable determination of sensory thresholds is the holy grail of signal detection theory. However, there exists no assumption-independent gold standard for the estimation of thresholds based on neurophysiological parameters, although a reliable estimation method is crucial for both scientific investigations and clinical diagnosis. Whenever it is impossible to communicate with the subjects, as in studies with animals or neonates, thresholds have to be derived from neural recordings or by indirec...
1 CitationsSource
#1Achim Schilling (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Richard Gerum (FAU: University of Erlangen-Nuremberg)H-Index: 6
Last. Holger Schulze (FAU: University of Erlangen-Nuremberg)H-Index: 16
view all 6 authors...
Reliable determination of sensory thresholds is the holy grail of signal detection theory. However, there exists no assumption-independent gold standard for the estimation of thresholds based on neurophysiological parameters, although a reliable estimation method is crucial for both scientific investigations and clinical diagnosis. Whenever it is impossible to communicate with the subjects, as in studies with animals or neonates, thresholds have to be derived from neural recordings or by indirec...
1 CitationsSource
#1Patrick KraussH-Index: 6
#2Marc SchusterH-Index: 1
Last. Claus MetznerH-Index: 11
view all 6 authors...
1 CitationsSource
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