Heiko Schuster
University of Tübingen
43Publications
12H-index
436Citations
Publications 43
Newest
Published on Feb 7, 2019in Blood 15.13
Tatjana Bilich2
Estimated H-index: 2
(University of Tübingen),
Annika Nelde3
Estimated H-index: 3
+ 22 AuthorsMarian Christoph Neidert9
Estimated H-index: 9
(University of Zurich)
Anti-leukemia immunity plays an important role in disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Thus, antigen-specific immunotherapy holds promise to strengthen immune control in CML, but requires the identification of CML-associated targets. In this study, we used a mass spectrometry-based approach to identify naturally presented, HLA class I- and class II-restricted peptides in primary CML samples. Comparative HLA ligandome...
2 Citations Source Cite
Published on Feb 22, 2019in Analytical Chemistry 6.04
John Patrick Murphy2
Estimated H-index: 2
(Dalhousie University),
Qijia Yu (Harvard University)+ 11 AuthorsAditya Jain (Harvard University)
MHC-I peptides are intracellular-cleaved peptides, usually 8-11 amino acids in length, which are presented on the cell surface and facilitate CD8+ T cell responses. Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement in patient outcomes, the MHC-I peptide ligands that facilitate the response are poorly described. Along these same lines, although many therapies have been recognized for their ability to reinvigorate anti-tumor CD8+ T cell responses, whether thes...
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Published on Jun 1, 2018in Proteomics 3.53
Jens Fritsche6
Estimated H-index: 6
,
Barbara Rakitsch7
Estimated H-index: 7
+ 14 AuthorsArun Satelli14
Estimated H-index: 14
3 Citations Source Cite
Published on Aug 7, 2018in Scientific Data 5.31
Heiko Schuster12
Estimated H-index: 12
,
Wenguang Shao2
Estimated H-index: 2
+ 10 AuthorsOliver Planz
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Published on Aug 15, 2018in Cancer Research 9.13
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Daniel J. Kowalewski10
Estimated H-index: 10
(University of Tübingen)
+ 15 AuthorsStefan Beckert17
Estimated H-index: 17
Immune cell infiltrates have proven highly relevant for colorectal carcinoma prognosis, making colorectal cancer a promising candidate for immunotherapy. Because tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here, we comprehensively describe the naturally presented HLA ligandome of colorectal carcinoma and corresponding nonmalignant colon (NMC) tissue. Mass spectrometry i...
2 Citations Source Cite
Published on Jan 4, 2018in Nucleic Acids Research 11.56
Wenguang Shao2
Estimated H-index: 2
(ETH Zurich),
Patrick G. A. Pedrioli21
Estimated H-index: 21
(ETH Zurich)
+ 43 AuthorsFabio Marino13
Estimated H-index: 13
(Utrecht University)
Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at the cell surface by major histocompatibility complex (MHC) molecules. The broad clinical relevance of MHC-associated peptides, e.g. in precision medicine, provides a strong rationale for the large-scale generation of immunopeptidomic datasets and recent developments in MS-based peptide analysis technologies now support the generation of the required data. Importantly, the availability of diverse i...
19 Citations Source Cite
Published on Jul 4, 2017in Oncotarget
Linus Backert7
Estimated H-index: 7
,
Daniel J. Kowalewski10
Estimated H-index: 10
+ 14 AuthorsDietger Niederwieser84
Estimated H-index: 84
// Linus Backert 1, 2, * , Daniel Johannes Kowalewski 1, 3, * , Simon Walz 1, 4 , Heiko Schuster 1, 3 , Claudia Berlin 1, 4 , Marian Christoph Neidert 5 , Mirle Schemionek 6 , Tim H. Brummendorf 6 , Vladan Vucinic 7 , Dietger Niederwieser 7 , Lothar Kanz 4 , Helmut Rainer Salih 4, 8 , Oliver Kohlbacher 2, 9, 10 , Katja Weisel 4 , Hans-Georg Rammensee 1, 11 , Stefan Stevanovic 1, 11 and Juliane Sarah Walz 4 1 Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, ...
5 Citations Source Cite
Published on Apr 7, 2017in Journal of Proteome Research 3.95
J. Patrick Murphy10
Estimated H-index: 10
(Dalhousie University),
Prathyusha Konda2
Estimated H-index: 2
(Dalhousie University)
+ 9 AuthorsStefan Stevanovic69
Estimated H-index: 69
(University of Tübingen)
Class I major histocompatibility complex (MHC-I)-bound peptide ligands dictate the activation and specificity of CD8+ T cells and thus are important for devising T-cell immunotherapies. In recent times, advances in mass spectrometry (MS) have enabled the precise identification of these MHC-I peptides, wherein MS spectra are compared against a reference proteome. Unfortunately, matching these spectra to reference proteome databases is hindered by inflated search spaces attributed to a lack of enz...
12 Citations Source Cite
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen),
Janet Kerstin Peper6
Estimated H-index: 6
(University of Tübingen)
+ 21 AuthorsNico Trautwein6
Estimated H-index: 6
(University of Tübingen)
Abstract Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer therapy by releasing the power of the immune system. However, only little is known about the antigens that are essentially presented on cancer cells, capable of exposing them to immune cells. Large-scale HLA ligandome analysis has enabled us to exhaustively characterize the immunopeptidomic landscape of epithelial ovarian cancers (EOCs). Additional comparative profiling with the immunopeptidome of a...
17 Citations Source Cite
Published on Mar 4, 2017in OncoImmunology 5.50
Annika Nelde3
Estimated H-index: 3
(University of Tübingen),
Juliane S. Walz5
Estimated H-index: 5
(University of Tübingen)
+ 14 AuthorsRainer Claus31
Estimated H-index: 31
(University of Freiburg)
ABSTRACTGenome sequencing has uncovered an array of recurring somatic mutations in different non-Hodgkin lymphoma (NHL) subtypes. If affecting protein-coding regions, such mutations may yield mutation-derived peptides that may be presented by HLA class I proteins and recognized by cytotoxic T cells. A recurring somatic and oncogenic driver mutation of the Toll-like receptor adaptor protein MYD88, Leu265Pro (L265P) was identified in up to 90% of different NHL subtype patients. We therefore screen...
5 Citations Source Cite
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