So Young Kwon
Konkuk University
VirologyHepatitis BHepatitis B virusDiabetes mellitusMedicine
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Publications 120
#1Byung Soo Kwan (Konkuk University)
#2Jeong Han Kim (Konkuk University)H-Index: 14
Last. Byung Chul Yoo (Konkuk University)H-Index: 3
view all 6 authors...
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC patients with HCC. Methods: We retrospectively analyzed CHC patients treated with DAA from 2016 to 2018. Patients were divided into two groups based on their HCC-history before DAA therapy. Baseline chara...
#1Young-Sun Lee (KU: Korea University)H-Index: 20
#2Yang Jae YooH-Index: 7
Last. Jeong Woo Kim (KU: Korea University)H-Index: 5
view all 15 authors...
INTRODUCTION: Because nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease, noninvasive evaluations of its severity are immediately needed. This prospective cross-sectional study evaluated the effectiveness of noninvasive assessments of hepatic steatosis, fibrosis, and steatohepatitis. METHODS: Patients underwent laboratory tests, liver biopsy, transient elastography, and MRI. Multiparametric MR was used to measure MRI proton density fat fraction, MR spec...
1 CitationsSource
#1Kang Hyun Park (Konkuk University)
#2Jeong Han Kim (Konkuk University)H-Index: 14
Last. Mi Hye Yu (Konkuk University)H-Index: 16
view all 11 authors...
Background/Aims: A switch to systemic therapy, such as sorafenib, should be considered for hepatocellular carcinoma (HCC) patients refractory to transarterial chemoembolization (TACE). On the other hand, treatment changes are difficult if the liver function worsens to Child-Pugh B or C. Therefore, predicting the risk factors for non-responsiveness to TACE and deteriorating liver function may be helpful. Methods: Newly diagnosed Child-Pugh A HCC patients who underwent TACE from January 2012 to Ju...
#1Young-Sun Lee (KU: Korea University)H-Index: 20
#1Young Sun LeeH-Index: 7
Last. Jong Eun Yeon (KU: Korea University)H-Index: 24
view all 12 authors...
Alpha fetoprotein (AFP) has been used as a serologic indicator of hepatocellular carcinoma (HCC). We aimed to identify an HCC-specific serum biomarker for diagnosis using a multiplexed proteomic technique in HCC patients with normal AFP levels. A total of 152 patients were included from Guro Hospital, Korea University. Among 267 identified proteins, 28 and 86 proteins showed at least a two-fold elevation or reduction in expression, respectively. Multiple reaction monitoring (MRM) analysis of 41 ...
#1Jung Woong Seo (Konkuk University)H-Index: 2
#2Byung Soo Kwan (Konkuk University)
Last. Jung Hoon Lee (Konkuk University)
view all 10 authors...
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of hepatitis virus infection, as well as other prognostic factors affecting survival in patients with ICC. Methods: A retrospective chart review was performed for patients diagnosed with ICC between Augu...
#1Won Hyeok Choe (Konkuk University)H-Index: 17
#2Ki Jeong Kim (CAU: Chung-Ang University)H-Index: 1
Last. Bumjoon J. KimH-Index: 48
view all 7 authors...
BACKGROUND: Hepatitis B virus (HBV) DNA polymerase mutations usually occur to long term use of nucleos(t)ide analogues (NAs), but they can occur spontaneously in treatment-naive chronic hepatitis B (CHB) patients. The naturally occurring HBV DNA polymerase mutations might complicate antiviral therapy with NAs, leading to the generation of drug-resistant viral mutants and disease progression. The most common substitutions are known to be YMDD-motif mutations, but their prevalence and the influenc...
1 CitationsSource
#1Hee Sun ParkH-Index: 23
#2Won Hyeok ChoeH-Index: 17
Last. So Young KwonH-Index: 17
view all 8 authors...
BACKGROUND: Accurate detection of significant fibrosis (fibrosis stage 2 or higher on the METAVIR scale) is important especially for chronic hepatitis B (CHB) patients with high viral loads but with normal or mildly elevated alanine aminotransferase (ALT) levels because the presence of significant fibrosis is accepted as the indication for antiviral treatment. Liver biopsy is the reference standard for diagnosing significant fibrosis, but it is an invasive procedure. Consequently, noninvasive im...
#1Young Suk Lim (UOU: University of Ulsan)H-Index: 3
#2Geum-Youn Gwak (SMC: Samsung Medical Center)H-Index: 29
Last. Han Chu Lee (UOU: University of Ulsan)H-Index: 38
view all 9 authors...
Background & Aims Tenofovir disoproxil fumarate (TDF) monotherapy has displayed non-inferior efficacy to TDF plus entecavir (ETV) combination therapy in patients with hepatitis B virus (HBV) resistant to ETV and/or adefovir (ADV). Nonetheless, the virologic response rate was suboptimal in patients receiving up to 144 weeks of TDF monotherapy. We aimed to assess the efficacy and safety of TDF monotherapy given for up to 240 weeks. Methods One trial enrolled patients with ETV resistance without AD...
2 CitationsSource
#1Eun-Sook Park (Konkuk University)H-Index: 11
#2Ah Ram Lee (Konkuk University)H-Index: 7
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 26 authors...
Background & Aims Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Methods Two patients with viral breakthrough during treatment with TDF-containing regimens were prospectively enrolled. The gene encoding HBV reverse transcriptase was sequenced. ...
5 CitationsSource
#1Jonggi ChoiH-Index: 7
#2Young-Suk LimH-Index: 4
Last. Geum-Youn GwakH-Index: 29
view all 9 authors...