Donald C. McMillan
Glasgow Royal Infirmary
CancerSurgeryPathologyColorectal cancerMedicine
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Publications 632
#1Antonia K. Roseweir (Glas.: University of Glasgow)H-Index: 11
#2James H. Park (Glas.: University of Glasgow)H-Index: 13
Last. Kieran Sheahan (UCD: University College Dublin)H-Index: 38
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#1Ross D. DolanH-Index: 6
#2L.E. DalyH-Index: 6
Last. Michael I. BennettH-Index: 44
view all 13 authors...
Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/ Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patien...
#1Aliah Alhayyan (Glas.: University of Glasgow)
#2Stephen T. McSorley (Glas.: University of Glasgow)H-Index: 11
Last. Donald C. McMillan (Glas.: University of Glasgow)H-Index: 69
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BACKGROUND/AIM: The magnitude of the postoperative systemic inflammatory response (SIR) is now recognised to be associated with both short and long-term outcomes in patients undergoing surgery for colon cancer. During such surgery, it is unclear whether the anaesthetic regimens influence the magnitude of the postoperative SIR, independent of other factors. The aim of the present study was to examine the association between anaesthetic agents, clinicopathological characteristics and the magnitude...
#1Dileep N. Lobo (NIHR: National Institute for Health Research)H-Index: 55
#2Luca Gianotti (University of Milano-Bicocca)H-Index: 35
Last. Stanislaw Klek (Memorial Hospital of South Bend)H-Index: 18
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Summary Background and aims Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in Nottingham, UK, on 14-15 October 2018 and the aims of this document were to highlight the scientific basis for the nutritional and metabolic management of surgical patients. Methods This paper represents the opinion of experts in this multidisciplinary field and those of a patient and caregiver, based on current evidenc...
#1Ross D. Dolan (Glasgow Royal Infirmary)H-Index: 6
#2Donald C. McMillan (Glasgow Royal Infirmary)H-Index: 69
Abstract The prognostic importance of SIR in patients with cancer is widely recognised. More recently it has become clear that the systemic inflammatory response is an important etiologic factor in the development of cancer cachexia. Two recent meta-analysis carried out in 2017 and 2018 were interrogated and the number of patients with specific cancer types were identified. The percentage of patients with operable cancer who were systemically inflamed varied from 21% to 38%. The percentage of pa...
#1L.E. Daly (UCC: University College Cork)H-Index: 6
#2Ross D. Dolan (Glas.: University of Glasgow)H-Index: 6
Last. Barry Laird (ECRC: Edinburgh Cancer Research Centre)H-Index: 21
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BACKGROUND: Optimizing quality of life (QoL) remains the central tenet of care in patients with incurable cancer; however, determinants of QoL are not clear. The objective of the current study was to examine which factors influence QoL in patients with incurable cancer. METHODS: A multicenter study of adult patients with advanced cancer was conducted in Ireland and the United Kingdom between 2011 and 2016. Data were collected from patients at study entry and included patient demographics, Easter...
BACKGROUND: Systemic inflammatory response (SIR) is an adverse prognostic marker in colorectal cancer (CRC) patients. The ScotScan Colorectal Cancer Group was established to examine how markers of the SIR differ between populations and may be utilised to guide prognosis. PATIENTS AND METHODS: Patients undergoing resection of stage I-III CRC from two prospective datasets in Scotland and Norway were included. The relationship between the modified Glasgow Prognostic Score (mGPS; combination of C-re...
#1Jitwadee InthagardH-Index: 1
#2Donald C. McMillanH-Index: 69
Last. Antonia K. RoseweirH-Index: 11
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#1Arfon Gethyn Powell (Cardiff University)
#2Colin Richards (Glas.: University of Glasgow)H-Index: 1
Last. Joanne Edwards (Glas.: University of Glasgow)H-Index: 38
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Purpose: The host inflammatory response is an important determinant of cancer outcome, however, the factor/s that regulate this response remains unclear. We aimed to determine if Human Leukocyte Antigen (HLA) class I and tumour cell proliferation are associated with CD8+ infiltration and survival in patients undergoing potentially curative resection for colorectal cancer. Methods: HLA class I expression (W6/32 and B2-microglobulin) and tumour proliferation index (Ki67) were quantified using immu...
#1Stephen T. McSorley (Glas.: University of Glasgow)H-Index: 11
#2Alexander Tham (Glas.: University of Glasgow)H-Index: 1
Last. Donald C. McMillan (Glas.: University of Glasgow)H-Index: 69
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Background The present study investigated relationships between perioperative blood transfusion, postoperative systemic inflammatory response, and outcomes following surgery for colorectal cancer.