Mitsuhiro Watanabe
Keio University
Publications 60
#1Anna NakamuraH-Index: 1
#2Naho KitamuraH-Index: 2
Last.Mitsuhiro WatanabeH-Index: 23
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A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin® is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin® and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin® by administering it to a mouse...
#1Hiroo Tanaka (Osaka University)H-Index: 7
#2Mitsunobu Imasato (Osaka University)H-Index: 6
Last.Sachiko Tsukita (Osaka University)H-Index: 45
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Abstract Background & Aims Most cholesterol gallstones have a core consisting of inorganic and/or organic calcium salts, although the mechanisms of core formation are poorly understood. We examined whether the paracellular permeability of ions at hepatic tight junctions is involved in the core formation of cholesterol gallstones, with particular interest in the role of phosphate ion, a common food additive and preservative. Methods We focused on claudin-3 (Cldn3), a paracellular barrier-forming ...
#1Edit Mikó (University of Debrecen)H-Index: 9
#2András Vida (University of Debrecen)H-Index: 8
Last.Péter Bai (University of Debrecen)H-Index: 27
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Abstract Our study aimed at finding a mechanistic relationship between the gut microbiome and breast cancer. Breast cancer cells are not in direct contact with these microbes, but disease could be influenced by bacterial metabolites including secondary bile acids that are exclusively synthesized by the microbiome and known to enter the human circulation. In murine and bench experiments, a secondary bile acid, lithocholic acid (LCA), reduced cancer cell proliferation (by 10–20%) and VEGF producti...
#1Shoji Yamada (Keio: Keio University)H-Index: 4
#2Yoko Takashina (Keio: Keio University)H-Index: 2
Last.Hidetsugu SaitoH-Index: 37
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// Shoji Yamada 1 , Yoko Takashina 2 , Mitsuhiro Watanabe 2 , Ryogo Nagamine 1 , Yoshimasa Saito 1, 3 , Nobuhiko Kamada 4 and Hidetsugu Saito 1, 3 1 Division of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan 2 Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa 252-0882, Japan 3 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan 4 Division of Gastr...
#1Norimitsu Ban (Keio: Keio University)H-Index: 6
#2Yoko Ozawa (Keio: Keio University)H-Index: 33
Last.Kazuo Tsubota (Keio: Keio University)H-Index: 87
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SIRT3 is a key regulator of mitochondrial reactive oxygen species as well as mitochondrial function. The retina is one of the highest energy-demanding tissues, in which the regulation of reactive oxygen species is critical to prevent retinal neurodegeneration. Although previous reports have demonstrated that SIRT3 is highly expressed in the retina and important in neuroprotection, function of SIRT3 in regulating reactive oxygen species in the retina is largely unknown. In this study, we investig...
#1Noriko SaegusaH-Index: 2
#2Shunji Sarukawa (Jichi Medical University)H-Index: 3
Last.Keita Inoue (Jichi Medical University)H-Index: 1
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#1Yukie Kusumoto (Keio: Keio University)H-Index: 2
#2Junichiro Irie (Keio: Keio University)H-Index: 16
Last.Hiroshi Itoh (Keio: Keio University)H-Index: 81
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Abstract Background Bile acid binding resin (BAR) absorbs intestinal bile acids, and improves obesity and metabolic disorders, but the precise mechanism remains to be clarified. Recent findings reveal that obesity is associated with skewed intestinal microbiota. Thus, we investigated the effect of BAR on intestinal microbiota and the role of microbiota in the prevention of obesity in high-fat diet-induced obesity in mice. Procedures Male Balb/c mice were fed a low-fat diet (LFD), high-fat diet (...
#1Hiroki Taoka (Keio: Keio University)H-Index: 1
#2Mitsuhiro Watanabe (Keio: Keio University)H-Index: 23
Bile acids (BAs) are not only facilitators of dietary lipid absorption but also important signaling molecules that participate in various metabolic pathways. Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor (FXR) and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs. BAs affect diverse metabolic pathways including glucose metabolism, lipid metabolism, and energy expenditure via these major pathways. Therefore, BA sign...
#1Kokoro Sano (Keio: Keio University)H-Index: 4
#2Motoko Kawashima (Keio: Keio University)H-Index: 19
Last.Kazuo Tsubota (Keio: Keio University)H-Index: 87
view all 10 authors...