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Ralph Bock
Max Planck Society
236Publications
65H-index
12.9kCitations
Publications 231
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#1Junjie Tan (MPG: Max Planck Society)H-Index: 1
#2Fei Zhang (MPG: Max Planck Society)H-Index: 1
Last.Ralph Bock (MPG: Max Planck Society)H-Index: 65
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RNA-guided nucleases of the CRISPR/Cas type can be repurposed as programmable nucleotide deaminases to mediate targeted nucleotide substitutions. Such base editors have enormous potential in genome editing, gene therapy and precision breeding. However, current editors suffer from limited specificity in that they edit different and/or multiple bases within a larger sequence window. Using cytidine deaminase base editors that elicit C-to-T mutations, we show here that high editing precision can be ...
11 CitationsSource
#1Junjie Tan (MPG: Max Planck Society)H-Index: 1
#2Fei Zhang (MPG: Max Planck Society)H-Index: 1
Last.Ralph Bock (MPG: Max Planck Society)H-Index: 65
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The original version of this Article contained an error in Figure 5. In the panel c, the right bar chart was inadvertently replaced with a duplicate of the left bar chart. This has been corrected in both the PDF and HTML versions of the Article.
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#1Letian Xu (Huda: Hubei University)H-Index: 1
#2Shijing Xu (Huda: Hubei University)
Last.Jiang Zhang (Huda: Hubei University)H-Index: 4
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RNA interference (RNAi) has emerged as an efficient tool to control insect pests. When lethal double-stranded RNAs (dsRNAs) were ingested by the insects, strong gene silencing and mortality can be induced. To exert their function, dsRNA molecules must pass through insect9s gut and enter epithelial cells and/or the hemolymph. Gut bacteria are known to inhabit on the epithelial surface to confer host new capabilities to counter both biotic and abiotic stress. Whether there is a crosstalk between g...
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#1Wanwan He (Huda: Hubei University)
#2Wenbo Xu (Huda: Hubei University)
Last.Jiang Zhang (Huda: Hubei University)H-Index: 4
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Transplastomic potato plants expressing double-stranded RNA (dsRNA) targeted against essential genes of the Colorado potato beetle (CPB) can be lethal to larvae by triggering an RNA interference (RNAi) response. High accumulation levels of dsRNAs in plastids are crucial to confer an efficient RNAi response in the insects. However, whether length and sequence of the dsRNA determine the efficacy of RNAi and/or influence the level of dsRNA accumulation in plastids is not known. Here we compared the...
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#1Maja Schuster (MPG: Max Planck Society)H-Index: 1
#2Yang Gao (MPG: Max Planck Society)H-Index: 1
Last.Reimo Zoschke (MPG: Max Planck Society)H-Index: 11
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#1Deserah D. Strand (MPG: Max Planck Society)H-Index: 3
#2Lucio D'Andrea (MPG: Max Planck Society)
Last.Ralph Bock (MPG: Max Planck Society)H-Index: 65
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#1F. Vanessa Loiacono (Cornell University)
#2Wolfram ThieleH-Index: 11
Last.Ralph Bock (MPG: Max Planck Society)H-Index: 65
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In chloroplasts and plant mitochondria, specific cytidines in mRNAs are post-transcriptionally converted to uridines by RNA editing. Editing sites are recognized by nucleus-encoded RNA-binding proteins of the pentatricopeptide repeat (PPR) family, which bind upstream of the editing site in a sequence-specific manner and direct the editing activity to the target position. Editing sites have been lost many times during evolution by C-to-T mutations. Loss of an editing site is thought to be accompa...
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#1Xiaohui Zhan (Huda: Hubei University)H-Index: 1
#2Fengjuan Zhang (Huda: Hubei University)H-Index: 1
Last.Jiang Zhang (Huda: Hubei University)H-Index: 4
view all 9 authors...
1 CitationsSource
#1André van EerdeH-Index: 2
#2Anikó Várnai (NMBU: Norwegian University of Life Sciences)H-Index: 19
Last.Jihong Liu-ClarkeH-Index: 1
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#1Guo-Zhang Wu (MPG: Max Planck Society)H-Index: 3
#2Etienne H. Meyer (MPG: Max Planck Society)H-Index: 26
Last.Ralph Bock (MPG: Max Planck Society)H-Index: 65
view all 4 authors...
Retrograde signals emanate from the DNA-containing cell organelles (plastids and mitochondria) and control the expression of a large number of nuclear genes in response to environmental and developmental cues. Previous studies on retrograde signaling have mainly analyzed the regulation of nuclear gene expression at the transcript level. To determine the contribution of translational and posttranslational regulation to plastid retrograde signaling, we combined label-free proteomics with transcrip...
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