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Raquel Ferreira
University of Beira Interior
42Publications
20H-index
1,410Citations
Publications 42
Newest
#1Cláudia Saraiva (UBI: University of Beira Interior)H-Index: 6
#2Sandra Barata-Antunes (UBI: University of Beira Interior)
Last.Liliana Bernardino (UBI: University of Beira Interior)H-Index: 22
view all 8 authors...
Evidence points to a dual role of histamine in microglia-mediated neuroinflammation, a key pathological feature of several neurodegenerative pathologies. Moreover, histamine has been suggested as a modulator of adult neurogenesis. Herein, we evaluated the effect of histamine in hippocampal neuroinflammation and neurogenesis under physiological and inflammatory contexts. For that purpose, mice were intraperitoneally challenged with lipopolysaccharide (LPS) followed by an intrahippocampal injectio...
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#1Ana S. Oliveira (UBI: University of Beira Interior)H-Index: 2
#2Cátia V. Vaz (UBI: University of Beira Interior)H-Index: 9
Last.Ana Palmeira-de-Oliveira (UBI: University of Beira Interior)H-Index: 12
view all 12 authors...
The common therapeutic indications of Portuguese Natural Mineral Waters (NMWs) are primarily for respiratory, rheumatic and musculoskeletal systems. However, these NMWs have been increasingly sought for dermatologic purposes. Opposing to what is observed in the major European Thermal Centres, there are few scientific evidences supporting the use of Portuguese NMWs for clinical applications. The aim of this study was to characterize the antimicrobial profile of individual NMWs from the central re...
Source
#1Tânia Faustino-Mendes (UBI: University of Beira Interior)
#2Marta Machado-Pereira (UBI: University of Beira Interior)H-Index: 3
Last.Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
view all 4 authors...
Source
#1Marta Machado-Pereira (UBI: University of Beira Interior)H-Index: 3
#2Tiago Santos (UBI: University of Beira Interior)H-Index: 15
Last.Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
view all 5 authors...
Abstract Perinatal stroke is often difficult to diagnose and an established treatment has not yet been validated, except for symptomatic measures. Herein, we propose to test the neuroprotective potential of the intravenous injection of retinoic acid-loaded nanoparticles (RA-NP) upon ischemic injury to the immature brain. The role of RA-NP on endothelial cells and organotypic slice cultures exposed to oxygen and glucose deprivation was assessed by evaluating markers pertaining to survival, prolif...
3 CitationsSource
#1Cláudia Saraiva (UBI: University of Beira Interior)H-Index: 6
#2Daniela Talhada (UBI: University of Beira Interior)H-Index: 2
Last.Karsten Ruscher (Lund University)H-Index: 23
view all 7 authors...
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were a...
4 CitationsSource
#1Marta Machado-Pereira (UBI: University of Beira Interior)H-Index: 3
#2Tiago Santos (UBI: University of Beira Interior)H-Index: 15
Last.Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
view all 5 authors...
Stroke is a leading cause of death in adult life, closely behind ischemic heart disease, and causes a significant and abiding socioeconomic burden. However, current therapies are not able to ensure full neurologic and/or sequelae-free recovery to all stroke survivors. We believe treatment efficacy and patient rehabilitation could be enhanced significantly by targeting blood-brain barrier (BBB) deregulation and inflammation-induced barrier loss occurring after stroke. In this pathological context...
3 CitationsSource
#1Tiago Santos (UBI: University of Beira Interior)H-Index: 15
#2Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
Last.Liliana Bernardino (UBI: University of Beira Interior)H-Index: 22
view all 10 authors...
Abstract Neurogenic niches constitute a powerful endogenous source of new neurons that can be used for brain repair strategies. Neuronal differentiation of these cells can be regulated by molecules such as retinoic acid (RA) or by mild levels of reactive oxygen species (ROS) that are also known to upregulate RA receptor alpha (RARα) levels. Data showed that neural stem cells from the subventricular zone (SVZ) exposed to blue light (405 nm laser) transiently induced NADPH oxidase-dependent ROS, r...
3 CitationsSource
#1Marta Machado-Pereira (UBI: University of Beira Interior)H-Index: 3
#2Tiago Santos (UBI: University of Beira Interior)H-Index: 15
Last.Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
view all 4 authors...
Angiogenesis and inflammation are clearly interconnected and interdependent processes that are dysregulated in a series of systemic and brain pathologies. Herein, key aspects regarding endothelial cell function and tissue remodelling that are particularly affected or aggravated by inflammation are presented. Most importantly, the cellular and molecular mechanisms involved in the vascular regulation of the inflammatory processes occurring in several brain disorders and how they impact on disease/...
5 CitationsSource
#1Marta Machado-Pereira (UBI: University of Beira Interior)H-Index: 3
#2Tiago Santos (UBI: University of Beira Interior)H-Index: 15
Last.Raquel Ferreira (UBI: University of Beira Interior)H-Index: 20
view all 5 authors...
Inflammatory mechanisms triggered by microglial cells are involved in the pathophysiology of several brain disorders, hindering repair. Herein, we propose the use of retinoic acid-loaded polymeric nanoparticles (RA-NP) as a means to modulate microglia response towards an anti-inflammatory and neuroprotective phenotype (M2). RA-NP were first confirmed to be internalized by N9 microglial cells; nanoparticles did not affect cell survival at concentrations below 100 μg/mL. Then, immunocytochemical s...
11 CitationsSource
#1Sandra Moreira Rocha (UBI: University of Beira Interior)H-Index: 6
#2Tatiana Saraiva (UBI: University of Beira Interior)H-Index: 2
Last.Liliana Bernardino (UBI: University of Beira Interior)H-Index: 22
view all 14 authors...
Background Histamine is an amine widely known as a peripheral inflammatory mediator and as a neurotransmitter in the central nervous system. Recently, it has been suggested that histamine acts as an innate modulator of microglial activity. Herein, we aimed to disclose the role of histamine in microglial phagocytic activity and reactive oxygen species (ROS) production and to explore the consequences of histamine-induced neuroinflammation in dopaminergic (DA) neuronal survival.
26 CitationsSource
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