Christen Lykkegaard Andersen
University of Copenhagen
Publications 64
#1Lene Kongsgaard Nielsen (OUH: Odense University Hospital)H-Index: 3
#2M. T. King (OUH: Odense University Hospital)H-Index: 46
Last.Niels Abildgaard (OUH: Odense University Hospital)H-Index: 21
view all 16 authors...
Purpose The quality of patient-reported outcome (PRO) data can be compromised by non-response (NR) to scheduled questionnaires, particularly if reasons for NR are related to health problems, which may lead to unintended bias. The aim was to investigate whether electronic reminders and real-time monitoring improve PRO completion rate.
#1Rudi Agius (DTU: Technical University of Denmark)
#2Christian Brieghel (Copenhagen University Hospital)H-Index: 2
Last.Carsten Utoft Niemann (Copenhagen University Hospital)H-Index: 16
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Infections have become the major cause of morbidity and mortality among patients with chronic lymphocytic leukemia (CLL) due to immune dysfunction and cytotoxic CLL treatment. Yet, predictive models for infection are missing. In this work, we develop the CLL Treatment-Infection Model (CLL-TIM) that identifies patients at risk of infection or CLL treatment within 2 years of diagnosis as validated on both internal and external cohorts. CLL-TIM is an ensemble algorithm composed of 28 machine learni...
We report the final two-year end-of-study results from the first clinical trial investigating combination treatment with ruxolitinib and low-dose pegylated interferon-α2 (PEG-IFNα2). The study included 32 patients with polycythemia vera (PV) and 18 with primary- or secondary myelofibrosis (MF); 46 patients were previously intolerant or refractory to PEG-IFNα2. The primary outcome was efficacy, based on hematological parameters, quality of life measurements, and JAK2 V617F allele burden. We used ...
#1Anders Fugl (UCPH: University of Copenhagen)H-Index: 1
#2Christen Lykkegaard Andersen (UCPH: University of Copenhagen)H-Index: 10
General practitioners encounter the vast majority of patients with Epstein-Barr virus-related disease, i.e. infectious mononucleosis in children and adolescents. With the expanding knowledge regarding the multifaceted role of Epstein-Barr virus in both benign and malignant disease we chose to focus this review on Epstein-Barr virus-related conditions with relevance to the general practitioners. A PubMed and Google Scholar literature search was performed using PubMed’s MeSH terms of relevance to ...
2 CitationsSource
#1Anne Beiter Arreskov (UCPH: University of Copenhagen)H-Index: 2
#2Maria Nathalie Angleys Olsen (UCPH: University of Copenhagen)H-Index: 1
Last.Niels de Fine Olivarius (UCPH: University of Copenhagen)H-Index: 18
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Survival from many cancer types is steadily increasing, and as a result, a growing number of cancer patients will live with other chronic diseases, of which diabetes is one of the most prevalent. This study aims to describe the impact of cancer on health outcomes in patients with type 2 diabetes and to compare the effectiveness of a multifactorial intervention in diabetes patients with and without cancer. The randomized controlled trial Diabetes Care in General Practice (DCGP) included 1381 pati...
1 CitationsSource
#1Suzanne McPherson ('QUB': Queen's University Belfast)H-Index: 3
#2Graeme Greenfield ('QUB': Queen's University Belfast)H-Index: 2
Last.Mary Frances McMullin ('QUB': Queen's University Belfast)H-Index: 46
view all 8 authors...
The myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal neoplastic disorders. Driver mutations in JAK2, CALR, and MPL genes have been identified in the majority of cases. Alongside these, an increasing number of genes are repeatedly identified as mutated in MPN. These, including ASXL1, TET2, DMNT3A, and EZH2, have key roles in epigenetic regulation. Dysregulation of epigenetic processes is therefore a key feature of MPN. Vorinostat is a pan histone deacetylase inhibitor (HDAC...
#1Ole Weis Bjerrum (OUH: Odense University Hospital)H-Index: 2
#2Volkert Siersma (UCPH: University of Copenhagen)H-Index: 30
Last.Christen Lykkegaard Andersen (RU: Roskilde University)H-Index: 10
view all 5 authors...
Abstract Introduction Eosinophilia may cause organ dysfunction, but an exact relation between eosinophil blood counts and adverse outcomes has not been described. The aim of the study is to associate in one model both normal and increased blood eosinophil counts to the subsequent development of common conditions in internal medicine, in which eosinophil granulocytes may play a role for the symptoms. Methods From the Copenhagen Primary Care Differential Count ( CopDiff ) Database, we identified 3...
#1Mads Emil Bjørn (UCPH: University of Copenhagen)H-Index: 2
#2Marie Klinge Brimnes (UCPH: University of Copenhagen)H-Index: 10
Last.Claus Henrik Nielsen (UCPH: University of Copenhagen)H-Index: 24
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AbstractThe role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been s...
2 CitationsSource
#2Robyn M. Scherber (University of Texas MD Anderson Cancer Center)H-Index: 9
Last.Ruben A. Mesa (University of Texas MD Anderson Cancer Center)H-Index: 63
view all 9 authors...
Introduction BMI increases the risk of Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) development. Patients with MPN often suffer from a severe symptom burden reduced quality of life. The aim of this study was to examine the association between BMI and symptom burden. Methods A comprehensive analysis of data from two large cross-sectional surveys of health-related quality of life in MPN patients was done by merging data from the Danish Population-based Study with data from t...
#2Robyn M. ScherberH-Index: 9
Last.Ruben A. MesaH-Index: 63
view all 9 authors...