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Jian-Guang Luo
China Pharmaceutical University
Organic chemistryChemistryChromatographyBiochemistryStereochemistry
210Publications
24H-index
2,265Citations
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Publications 213
Newest
#1Wenli WangH-Index: 3
Last. Ling-Yi KongH-Index: 36
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Taxodisones A and B, C30¬-terpenes with an unprecedented tetracyclo[12.4.0.0.2,709,14]octodecane core, were isolated from the seeds of Taxodium distichum. Their structures including configurations were unambiguously determined. Their biomimetic synthesis was described to suggest they stemmed from diterpenes and monoterpenes not from squalene or oxidosqualene. In addition, their bioactivities were also evaluated.
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#1Zhen Ao (CPU: China Pharmaceutical University)H-Index: 1
#2Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 1
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 24
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Abstract Hyperpatulones A (1) and B (2), two new polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from the leaves of Hypericum patulum. Their unusual 6,7,5-tricyclic system with a peroxide bridge structures were elucidated by comprehensive analysis of their spectroscopic and HRESIMS data. The absolute configuration of hyperpatulone A was determined by comparison between experimental and calculated electron circular dichroism (ECD) spectra. Compounds 1 and 2 exhibited moderate...
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#1Xin-Lin Chen (CPU: China Pharmaceutical University)H-Index: 1
#2Shang Xue (CPU: China Pharmaceutical University)
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
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Abstract In terms of ligand fishing, the amount and the relative activity recovery of enzymes immobilized on magnetic particles and nanoparticles are not preeminent. Therefore, the metal-organic framework (MOF) UiO-66-NH2 was synthesized to immobilize the porcine pancreatic lipase (PPL) via precipitation-cross-linking, and the resulting novel biological matrices named PPL@MOF manifested high PPL loading capacity (98.31 mg) and relative activity recovery (104.4%). Moreover, the novel enzyme-MOF c...
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#1Van-Tuan Vu (CPU: China Pharmaceutical University)H-Index: 1
#2Xin-Lin Chen (CPU: China Pharmaceutical University)H-Index: 1
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 24
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(±)-Melipatulinones A–C (1–3), three unique enantiomeric pairs of lignan–phloroglucinol hybrids along with the biogenetically related compound melipatulignan A (4), were isolated from the leaves of Melicope patulinervia. Melipatulinones A (1) and B (2) share a novel spiro[hydrobenzofuran-2,3′-furan] 5/5/6 tricyclic ring system, while melipatulinone C (3) features an unprecedented spiro[cyclopenta[b]hydrofuran-2,3′-furan] 5/5/5 tricyclic framework. Their structures were determined by spectroscopi...
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#1Van-Tuan Vu (CPU: China Pharmaceutical University)H-Index: 1
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 24
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Abstract Six new obovatol trimeric neolignans, houpulignans A–F (1–6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined on the basis of the interpretation of HRESIMS, NMR data, and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of neolignans derived from three units of obovatol bearing a rare 1,4-benzodioxepane moiety. Compound 3 possesses a benzodihydropyran ring, meanwhile three units of obovatol in 4...
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#1Kang Chen (CPU: China Pharmaceutical University)H-Index: 1
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
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Abstract Seven new taxane diterpenoids taxumarienes A–G (1–7) were isolated from the leaves of Taxus mairei, along with seven known analogous (8–14). The structures of the new compounds were elucidated based on the analysis of NMR and MS spectroscopy. All isolates were evaluated for their α-glucosidase inhibitory activities. Among them, taxumarienes A (1) and F (6) showed potent effect with IC50 values of 5.9 ± 1.30 μM and 3.7 ± 0.75 μM, respectively.
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#1Yaolan Lin (CPU: China Pharmaceutical University)H-Index: 2
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 10
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
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Abstract The ability to separate bioactive compounds from herbal medicines, which contain abundant components, is crucial for drug discovery. Conventional Countercurrent chromatography (CCC) methods for separating bioactive compounds are labor intensive and show low efficiency. Here, we present a novel integrative CCC method for separating lysine-specific demethylase 1 (LSD1) inhibitors from the roots of Salvia miltiorrhiza (RSM). The methanol extracts of RSM were separated into hydrosoluble and...
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#1Jin-Fang Xu (Shanxi Medical University)H-Index: 6
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 10
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
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Abstract Melicolones C–K (1–9), nine acetophenone derivatives with three unprecedented architectures, were characterized from the leaves of Melicope ptelefolia. Among them, melicolone C (1) was a novel acetophenone analogue possessing a highly rearranged spiro skeleton. Melicolones D-F (2–4) were three novel acetophenone congeners bearing unusual octalactone ring. Melicolones G-K (5–9) were five new prenylated acetophenone derivatives featuring a 9-oxatricyclo [3.2.1.13, 8]nonane core. Their str...
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#1Ling-Nan Li (CPU: China Pharmaceutical University)H-Index: 3
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 9 authors...
A pair of novel C23 terpenoid epimers, officinalins A (1) and B (2), together with a biogenetically related known diterpenoid (3), was isolated from the leaves of Salvia officinalis. The epimers feature an unprecedented carbon skeleton with a tetracycline-[9.6.0.03,8.012,16]-heptadecane core and a peroxide bridge. Their structures were unequivocally established by extensive spectroscopic analyses, including electronic circular dichroism (ECD) calculations and ROESY correlation analogy with model...
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#1Jian Xu (CPU: China Pharmaceutical University)H-Index: 5
#2Yun-Wei Hu (MOE: Chinese Ministry of Education)H-Index: 1
Last. Jie Zhang (CPU: China Pharmaceutical University)H-Index: 10
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Abstract Chemical investigation of the EtOAc extract of the plant-associated fungus Alternaria alternate in rice culture led to the isolation of a novel liphatic polyketone, alternin A ( 1 ), a new indole alkaloid ( 8 ), and a new sesquiterpene ( 11 ), together with 12 known compounds. Their structures were elucidated by the interpretation of extensive spectroscopic data, and the absolute configurations of 1 – 3 were established using calculations of ECD spectra, NMR data, and optical rotation v...
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