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Jian-Guang Luo
China Pharmaceutical University
222Publications
23H-index
2,065Citations
Publications 222
Newest
#1Yaolan Lin (CPU: China Pharmaceutical University)H-Index: 1
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 6
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 8 authors...
Abstract The ability to separate bioactive compounds from herbal medicines, which contain abundant components, is crucial for drug discovery. Conventional Countercurrent chromatography (CCC) methods for separating bioactive compounds are labor intensive and show low efficiency. Here, we present a novel integrative CCC method for separating lysine-specific demethylase 1 (LSD1) inhibitors from the roots of Salvia miltiorrhiza (RSM). The methanol extracts of RSM were separated into hydrosoluble and...
#1Jian Xu (CPU: China Pharmaceutical University)H-Index: 5
#2Yun-Wei Hu (MOE: Chinese Ministry of Education)
Last.Jie Zhang (CPU: China Pharmaceutical University)H-Index: 10
view all 10 authors...
Abstract Chemical investigation of the EtOAc extract of the plant-associated fungus Alternaria alternate in rice culture led to the isolation of a novel liphatic polyketone, alternin A ( 1 ), a new indole alkaloid ( 8 ), and a new sesquiterpene ( 11 ), together with 12 known compounds. Their structures were elucidated by the interpretation of extensive spectroscopic data, and the absolute configurations of 1 – 3 were established using calculations of ECD spectra, NMR data, and optical rotation v...
#1Wenli Wang (CPU: China Pharmaceutical University)H-Index: 2
#2Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 1
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 9 authors...
#1Jin-Fang Xu (CPU: China Pharmaceutical University)H-Index: 6
#2Chao Han (CPU: China Pharmaceutical University)H-Index: 6
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 8 authors...
A synthesis-inspired chemical investigation of the leaves of Melicope ptelefolia led to the isolation of evodialones A–D (1–4), four rearranged acetophenone stereoisomers possessing a prenylated acylcyclopentenone skeleton with three stereogenic carbons. Evodialones C and D (3 and 4) are new minor constituents. The chiral-phase HPLC resolution gave (+)-1–4 and (−)-1–4, eight enantiomers forming a complete stereoisomer library. Their absolute configurations were elucidated via extensive spectrosc...
#1Yang-Yang Liu (CPU: China Pharmaceutical University)H-Index: 1
#2Zhen Ao (CPU: China Pharmaceutical University)H-Index: 1
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
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Abstract Nine new spirocyclic acylphloroglucinol derivatives, hyperpatulols A–I ( 1 – 9 ), were characterized from the flowers of Hypericum patulum . Their structures were elucidated by the basic analysis of the obtained spectroscopic data, and their absolute configurations were assigned by both the electronic circular dichroism (ECD) exciton chirality method and ECD calculation. The evaluation of their anti-migration effects on U2-OS human osteosarcoma cells showed that compound 4 exhibited mod...
#1Ling-Nan Li (CPU: China Pharmaceutical University)H-Index: 2
#2Shanshan Wei (CPU: China Pharmaceutical University)H-Index: 1
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 9 authors...
Abstract As an aromatic plant of the Labiatae family, Salvia officinalis L. (sage), is cultured worldwide, especially in Mediterranean region. The leaves of sage are used as a popular herbal tea, drug and seasoning. In the present study, eight novel C 20 -norabietane diterpenoids (salofficinoids A-H, 1 – 8 ), along with four known analogues ( 9 – 12 ) which were responsible for the anti-inflammatory activity, were purified from the sage leaves via bioassay-guided fractionation. Their structures ...
#1Gui-Min Xue (CPU: China Pharmaceutical University)H-Index: 5
#2Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 1
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 6 authors...
Abstract Artemisianins A-D ( 1 – 4 ), four stereoisomers of sesquiterpenoid dimers, forming via [4+2] cycloaddition from a 1, 10-seco-guaianolide dienophile and a guaianolide diene, along with two biosynthetically related precurors 5 and 6 , were isolated from the famous traditional Chinese medicine Artemisia argyi . The structures of 1 – 4 , including their absolute configurations, were elucidated by extensive spectroscopic data and ECD/TDDFT calculation analysis. Compounds 1 – 4 exhibited cyto...
#1Ya-Long Zhang (CPU: China Pharmaceutical University)H-Index: 7
#2Qi-Qi Xu (CPU: China Pharmaceutical University)H-Index: 1
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 9 authors...
Abstract Thirteen undescribed dimeric guaianes were isolated from the leaves of Xylopia vielana Pierre. Their structures were elucidated by NMR spectroscopy and mass spectrometry, and the absolute configurations of vielanins G-Q were determined by a combination of the circular dichroism (CD) exciton chirality method, chemical conversion, and electronic CD (ECD) spectroscopy analysis. Vielaninors A and B are the first examples of trinor-guaiane-dimers. Multidrug resistance reversal activity assay...
#1Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 1
#2Chen Chen (CPU: China Pharmaceutical University)H-Index: 4
Last.Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 23
view all 5 authors...
Background. Pharbitis Semen, the seeds of Pharbitis nil, is widely used as a traditional purgative medicine in China, Korea, and Japan. This study investigated the laxative effects of a purified resin glycoside fraction obtained in our previous study from Pharbitis Semen in vivo and in vitro. Materials and Methods. After orally administering a purified resin glycoside fraction from Pharbitis Semen (RFP) to rats, the content of fecal water, AQP3, NF-κB, COX-2 expression, and the prostaglandin E2 ...
#1Tianyu Zhu (CPU: China Pharmaceutical University)H-Index: 1
#2Chen Chen (CPU: China Pharmaceutical University)H-Index: 4
Last.Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 8 authors...
Withangulatin A (WA) has been reported to exhibit potent antitumor activity. However, its possible mechanism and direct proteomic targets remain unknown. Herein we report the subcellular localization of WA by designing and synthesizing its fluorescent analogues with coumarin moieties. Furthermore, sarco/endoplasmic reticulum calcium-ATPase (SERCA)2 was identified as the potential target of WA for its antitumor activity by chemical proteomics.
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