Naglaa Assaf
Misr University for Science and Technology
NephrotoxicityEndocrinologyOxidative stressMalondialdehydeBiochemistry
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Publications 13
#1Mohammed F. El-Yamany (Cairo University)H-Index: 1
#2Noha F. Abdelkader (Cairo University)H-Index: 7
Last. Wesam H. Elesawy (Misr University for Science and Technology)
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Abstract Valproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity. The present study investigated the hepatoprotective effect of ellagic acid against valproic acid-induced hepatotoxicity in rats. Ellagic acid (60 mg/kg/day; p.o) was treated for one week, followed by concomitant injection of valproic acid (250 mg/kg/day; i.p.) for another 14 consecut...
Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammatory and anti-apoptotic effects. The aim of our study was to elucidate the unique neuroprotective role of NAT in the middle cerebral artery occlusion (MCAO)-induced stroke in rats. Fi...
#1Naglaa Assaf (Misr University for Science and Technology)H-Index: 6
Last. Nesrine S. El Sayed (Cairo University)H-Index: 5
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Abstract The present study was conducted to evaluate the efficacy of fenofibrate and pioglitazone in a mouse model of amyloidogenesis induced by amyloidβ (βA) peptide. Mice were injected intracerebroventricularly with βA1-40 (400 pmol/mouse) once, followed by treatment with fenofibrate (300 mg/kg), pioglitazone (30 mg/kg),or both. After 21 days of daily treatment, memory impairment and cognitive function were evaluated by Morris water maze (MWM), Y-maze and object recognition tests. On the 22nd ...
#2Rabab H. Sayed (Cairo University)H-Index: 5
Last. Adel F. HashishH-Index: 2
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Abstract Polydrug use among adolescence is a widespread phenomenon and has increased in the last few years. In particular, most nandrolone decanoate (Nan) abusers combine its use with cannabis (Can); thus, studying the consequences of this combination in adolescent subjects is important because potentiation of their effects may increase their neurotoxicity. The present study was designed to study the neurotoxic effects of Nan and Can, alone and in combination, in adolescent male rats by studying...
#2Mohammed F. El-Yamany (Cairo University)H-Index: 1
Last. Hamdy A. Ghoneim (Mansoura University)H-Index: 5
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Abstract Early detection and clinical interference are major challenges for the prevention of diabetic nephropathy (DN) progression. This study investigated the effects of dapagliflozin, a sodium glucose co-transporter 2 inhibitor, on some early markers for DN in fructose-streptozotocin (Fr-STZ)-induced diabetes in rats. Fr-STZ rats were treated with either dapagliflozin (1 mg/kg p.o. daily), metformin (350 mg/kg p.o. daily), or their combination for 6 weeks. Fr-STZ rats displayed marked early t...
#1Neveen A. SalemH-Index: 7
#2Nawal HelmiH-Index: 1
Last. Naglaa Assaf (Misr University for Science and Technology)H-Index: 6
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Platelet-rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties. It is considered as a source of growth factors that may induce tissue repairing and improve fibrosis. This product has proven its efficacy in multiple studies, but its effect on cisplatin-induced nephrotoxicity has not yet been elucidated. The present investigation was performed to estimate the protective impact of platelet-rich plasma against cisplatin- (CP-) e...
7 CitationsSource
#1Neveen A. SalemH-Index: 7
#2Naglaa AssafH-Index: 6
Last. Mohga Samy (Cairo University)H-Index: 1
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Multiple sclerosis, an autoimmune inflammatory disease of the central nervous system, is characterized by excessive demyelination. The study aimed to investigate the possible protective effect of ozone (O3) therapy in ethidium bromide (EB)-induced demyelination in rats either alone or in combination with corticosteroids in order to decrease the dose of steroid therapy. Rats were divided into Group (1) normal control rats received saline, Group (2) Sham-operated rats received saline, Group (3) Sh...
9 CitationsSource
#1Wagdy K. B. KhalilH-Index: 8
#2Naglaa Assaf (Misr University for Science and Technology)H-Index: 6
Last. Neveen A. SalemH-Index: 7
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Abstract Parkinson's disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic neurodegeneration, mitochondrial impairment, and oxidative stress. Exposure of animals to rotenone induces a range of responses characteristic of PD, including reactive oxygen species production and dopaminergic cell death. Although l -dopa is the drug of choice for improving core symptoms of PD, it is associated with involuntary movements. The current study was directed to ev...
27 CitationsSource
Background: Obesity, a worldwide health problem, is a metabolic dis- ease currently associated with a cluster and pro- gressive pathologies presenting several features of metabolic syndrome. Objectives: The present study was undertak- en to investigate the effect of rimonabant, sim- vastatin and their combination on obesity asso- ciated metabolic disorder mediators in adult male rats. Materials and Methods: Fifty adult male Wis- tar rats weighing (120 ± 10 g) were divided into five groups: Group...
6 Citations