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Kohichi Tanaka
Tokyo Medical and Dental University
180Publications
51H-index
9,718Citations
Publications 180
Newest
Published on Dec 1, 2018in Nature Communications 12.35
Shota Nakade6
Estimated H-index: 6
(Hiroshima University),
Keiji Mochida2
Estimated H-index: 2
(Hiroshima University)
+ 6 AuthorsTakashi Yamamoto43
Estimated H-index: 43
(Hiroshima University)
Selective genome editing such as gene knock-in has recently been achieved by administration of chemical enhancer or inhibitor of particular DNA double-strand break (DSB) repair pathways, as well as overexpression of pathway-specific genes. In this study, we attempt to enhance the efficiency further to secure robust gene knock-ins, by using the local accumulation of DSB repair molecules (LoAD) system. We identify CtIP as a strong enhancer of microhomology-mediated end-joining (MMEJ) repair by gen...
2 Citations Source Cite
Published on Sep 1, 2018in Glia 5.85
Zhuoyang Zhao1
Estimated H-index: 1
(Tokyo Medical and Dental University),
Yuichi Hiraoka3
Estimated H-index: 3
(Tokyo Medical and Dental University)
+ 1 AuthorsKohichi Tanaka51
Estimated H-index: 51
(Tokyo Medical and Dental University)
1 Citations Source Cite
Published on Aug 1, 2018in Human Molecular Genetics 4.90
Emma M. Perkins9
Estimated H-index: 9
(University of Edinburgh),
Yvonne L. Clarkson6
Estimated H-index: 6
(University of Edinburgh)
+ 6 AuthorsMandy Jackson13
Estimated H-index: 13
(University of Edinburgh)
2 Citations Source Cite
Published on May 2, 2018in The EMBO Journal 10.56
Bettina Reichenbach1
Estimated H-index: 1
(Karolinska Institutet),
Johanna Classon2
Estimated H-index: 2
(Karolinska Institutet)
+ 3 AuthorsChristian Göritz16
Estimated H-index: 16
(Karolinska Institutet)
Abstract Tissues contain distinct stem cell niches, but whether cell turnover is coordinated between niches during growth is unknown. Here, we report that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. During hair growth, cells in the bulge and outer root sheath temporarily upregulate the glutamate transporter SLC1A3, and the number of SLC1A3 + basal cells in interfollicular epidermis and sebaceous gland increases. Fate mapping of SLC1A3 + c...
3 Citations Source Cite
Published on Apr 1, 2018in Glia 5.85
Junya Sugimoto1
Estimated H-index: 1
(Tokyo Medical and Dental University),
Moeko Tanaka1
Estimated H-index: 1
(Tokyo Medical and Dental University)
+ 6 AuthorsKohichi Tanaka51
Estimated H-index: 51
(Tokyo Medical and Dental University)
5 Citations Source Cite
Kaori Sugiyama2
Estimated H-index: 2
(Tokyo Medical and Dental University),
Kohichi Tanaka51
Estimated H-index: 51
(Tokyo Medical and Dental University)
Abstract Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disorder characterized by the selective loss of motor neurons. The precise mechanisms that cause the selective death of motor neurons remain unclear, but a growing body of evidence suggests that glutamate-mediated excitotoxicity has been considered to play an important role in the mechanisms of motor neuron degeneration in ALS. Reductions in glutamate transporter GLT1 have been reported in animal models of ALS and the mo...
Source Cite
Published on Sep 6, 2017in The Journal of Neuroscience 5.97
Kaori Sugiyama2
Estimated H-index: 2
(Tokyo Medical and Dental University),
Tomomi Aida11
Estimated H-index: 11
(Tokyo Medical and Dental University)
+ 3 AuthorsKohichi Tanaka51
Estimated H-index: 51
(Tokyo Medical and Dental University)
Glutamate-mediated excitotoxicity induces neuronal death by altering various intracellular signaling pathways and is implicated as a common pathogenic pathway in many neurodegenerative diseases. In the case of motor neuron disease, there is significant evidence to suggest that overactivation of AMPA receptors due to deficiencies in the expression and function of glial glutamate transporter GLT1 and GLAST plays an important role in the mechanisms of neuronal death. However, a causal role for glia...
6 Citations Source Cite
Taisuke Miyazaki26
Estimated H-index: 26
(Hokkaido University),
Miwako Yamasaki27
Estimated H-index: 27
(Hokkaido University)
+ 6 AuthorsMasahiko Watanabe101
Estimated H-index: 101
(Hokkaido University)
Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential for synaptic organization in PCs through the action of the l-glutamate/l-aspartate transporter (GLAST). In GLAST-knockout mice, dendritic innervation by the main ascending climbing ...
9 Citations Source Cite
Published on May 18, 2017in JCI insight
Ken-ichiro Kubo20
Estimated H-index: 20
,
Kimiko Deguchi10
Estimated H-index: 10
+ 24 AuthorsMichihiko Aramaki10
Estimated H-index: 10
4 Citations Source Cite
Published on Mar 1, 2017in Scientific Reports 4.12
Tomoharu Nakamori6
Estimated H-index: 6
,
Tomomi Kato1
Estimated H-index: 1
+ 2 AuthorsHiroko Ohki-Hamazaki19
Estimated H-index: 19
Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells
1 Citations Source Cite
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