Kathleen E. Rodgers
University of Southern California
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Publications 194
#1Gregory L. Branigan (UA: University of Arizona)
#2Maira Soto (UA: University of Arizona)H-Index: 1
Last. Roberta Diaz Brinton (UA: University of Arizona)H-Index: 57
view all 5 authors...
Importance: The association between exposure to hormone-modulating therapy (HMT) as breast cancer treatment and neurodegenerative disease (NDD) is unclear. Objective: To determine whether HMT exposure is associated with the risk of NDD in women with breast cancer. Design, Setting, and Participants: This retrospective cohort study used the Humana claims data set from January 1, 2007, to March 31, 2017. The Humana data set contains claims from private-payer and Medicare insurance data sets from ac...
#1Roslynn Stone (SC: University of Southern California)H-Index: 1
#2Siyu Liu (SC: University of Southern California)H-Index: 5
Last. Brett T. Lund (SC: University of Southern California)H-Index: 11
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The renin angiotensin system (RAS), which is classically known for blood pressure regulation, has functions beyond this. There are two axes of RAS that work to counterbalance each other and are active throughout the body, including the CNS. The pathological axis, consisting of angiotensin II (A1-8), angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT1R), is upregulated in many CNS diseases, including multiple sclerosis (MS). MS is an autoimmune and neurodegenerative di...
#1Maira Soto (UA: University of Arizona)H-Index: 1
#2Kevin J. Gaffney (UA: University of Arizona)H-Index: 8
Last. Kathleen E. Rodgers (UA: University of Arizona)H-Index: 32
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Patients with Type 2 Diabetes Mellitus (T2DM) suffer from a higher incidence and severity of pulmonary infections. This is likely due to immune impairment and structural abnormalities caused by T2DM-induced oxidative stress (OS) and chronic inflammation. Modulation of the Renin Angiotensin System (RAS) through blockade of the actions of angiotensin II (AII), or inducing the protective pathway, has the potential to reduce these pathological pathways. The effects of Angiotensin 1-7 [A(1-7)] and No...
#1Brett T. Lund (SC: University of Southern California)H-Index: 11
#2R. Stone (SC: University of Southern California)
Last. Eve E. Kelland (SC: University of Southern California)H-Index: 8
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Abstract Multiple Sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by autoimmune and neurodegenerative pathologies for which there is no cure and no defined etiology. Although several, modestly effective, disease modifying drugs are available to treat MS, there are presently no treatments that offer neuroprotection and prevent clinical progression. Therapies are needed that control immune homeostasis, prevent disease progression, and stimulate regeneration in...
#1Daniel A. NationH-Index: 22
#2Duke Han (SC: University of Southern California)
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#1Meredith Hay (UA: University of Arizona)H-Index: 30
#2Robin L Polt (UA: University of Arizona)H-Index: 28
Last. John P. Konhilas (UA: University of Arizona)H-Index: 19
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Increasing evidence indicates that decreased brain blood flow, increased reactive oxygen species (ROS) production, and proinflammatory mechanisms accelerate neurodegenerative disease progression such as that seen in vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease and related dementias. There is a critical clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment known to occur in patients with VCID and chron...
#1Raju C. ReddyH-Index: 11
#2Isaac AsanteH-Index: 1
Last. Stan G. LouieH-Index: 31
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1 CitationsSource
#1Anna Malgorzata Papinska (SC: University of Southern California)H-Index: 3
#2Kathleen E. Rodgers (SC: University of Southern California)H-Index: 32
Aims. The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1–7) [A(1–7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods. db/db mice and heterozygous controls were treated with A(1–7) or vehicle daily, subcutaneously for up to 16 weeks. Kidney injury was assessed by measuring blood flow in renal arteries, plasma creatinine levels, and proteinuria. Effects of treatment on oxidative stress were...
1 CitationsSource
#1Kevin J. Gaffney (UA: University of Arizona)H-Index: 8
#2Michael Weinberg (SC: University of Southern California)
Last. Kathleen E. Rodgers (UA: University of Arizona)H-Index: 32
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Though widely used, cytotoxic chemotherapy is associated with potentially life threatening drug-induced neutropenia, thrombocytopenia, and anemia.[1][1]–[3][2] Beyond the acute dangers of infection, severe fatigue and uncontrolled bleeding, the hematological toxicities associated with these agents