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Purnima M. Samuel
Indian Institute of Chemical Technology
6Publications
3H-index
59Citations
Publications 6
Newest
Published on Jan 1, 2002in Bioorganic & Medicinal Chemistry Letters 2.45
Purnima M. Samuel3
Estimated H-index: 3
(Indian Institute of Chemical Technology),
Dick de Vos1
Estimated H-index: 1
+ 2 AuthorsSujit Roy29
Estimated H-index: 29
(IIT-KGP: Indian Institute of Technology Kharagpur)
Abstract Dibenzyltin(IV)dichloride and dibenzyltin(IV)diisothiocyanate derivatives with N,S-donor ligands show significant cytotoxic activities against human cancer cell lines, and are well compared to analogous dialkyltin(IV) derivatives. CoMFA models were generated for the first time for these organotin derivatives using the cytotoxic activities (against two human tumor cell lines, MCF-7, a mammary carcinoma and WiDr, a colon carcinoma) of 21 complexes. High r 2 and r 2 cv values for both CoMF...
37 Citations Source Cite
Published on Sep 1, 1998in Journal of Applied Toxicology 3.06
Purnima M. Samuel3
Estimated H-index: 3
(Indian Institute of Chemical Technology),
Sujit Roy29
Estimated H-index: 29
(Indian Institute of Chemical Technology)
+ 1 AuthorsJ. Venkateswara Rao1
Estimated H-index: 1
(Indian Institute of Chemical Technology)
In vitro effects of six dibenzyltin dichloride (A-series) and another six dibenzyltin diisothiocyanate (Bseries) complexes on Na 1 /K 1 -ATPase were studied. The rat brain synaptic membranes were prepared and significant ATPase inhibition was observed with all the complexes in a dose-dependent manner. The order of potency on Na 1 /K 1 -ATPase activity of the chloride complexes was found to be higher than that of the isothiocyanate complexes. The ic50 values range from 64 mM to 252 mM for the chl...
16 Citations Source Cite
1