Donald J. Chisholm
Garvan Institute of Medical Research
Publications 223
#1Alice TangH-Index: 1
#2Adelle C. F. CosterH-Index: 18
Last.Dorit Samocha-BonetH-Index: 21
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Background: Large cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing in older age. We aimed to assess the fate of insulin sensitivity per se over time in overweight and obese individuals. Methods: Individuals studied using the hyperinsulinaemic-euglycaemic clamp at the Garvan Institute of Medical Research from 2008 to 2010 (n = 99) were retrospectively grouped into Lean (body mass index (BMI) < 25 kg/m2) or overwe...
#1Katherine T. TonksH-Index: 7
#2Adelle C. F. CosterH-Index: 18
Last.Dorit Samocha-BonetH-Index: 21
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Objective Alterations in lipids in muscle and plasma have been documented in insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear. Methods Nondiabetic sedentary individuals not treated with lipid-lowering medications were studied (n = 51). Subjects with body mass index (BMI) > 25 kg/m2 (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic-euglycemic clamp into insulin-sensitive ...
58 CitationsSource
#1Edward W. KraegenH-Index: 67
#2Gregory J. CooneyH-Index: 55
Last.Donald J. ChisholmH-Index: 62
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#1Daniel L. T ChenH-Index: 4
#2Carsten Liess (Philips)H-Index: 3
Last.Jerry R. Greenfield (St. Vincent's Health System)H-Index: 36
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Context: Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. Objective: We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals. Design and Participants: Sixty-four nondiabetic obese adults (29 males) underwent hyperinsulinemic (15 and 80 mU/m2 · min)-euglycemic clamps with deuterated glucose. Top tertile subjects for glucose infusion rate during the high-dose insulin clamp were as...
25 CitationsSource
#1Dorit Samocha-BonetH-Index: 21
#2Donald J. ChisholmH-Index: 62
Last.Jerry R. GreenfieldH-Index: 36
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l-glutamine triggers glucagon-like peptide-1 (GLP-1) release from L cells in vitro and when ingested pre-meal, decreases postprandial glycaemia and increases circulating insulin and GLP-1 in type 2 diabetes (T2D) patients. We aimed to evaluate the effect of oral l-glutamine, compared with whole protein low in glutamine, on insulin response in well-controlled T2D patients. In a randomized study with a crossover design, T2D patients (n = 10, 6 men) aged 65.1 ± 5.8, with glycosylated hemoglobin (Hb...
5 CitationsSource
#1Xiuquan Ma (USYD: University of Sydney)H-Index: 5
#2Paul Lee (Garvan Institute of Medical Research)H-Index: 14
Last.David E. James (USYD: University of Sydney)H-Index: 81
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Adipocyte differentiation and its impact on restriction or expansion of particular adipose tissue depots has physiological and pathophysiological significance in view of the different functions of these depots. Brown or “beige” fat [BAT] expansion can enhance thermogenesis, lipid oxidation, insulin sensitivity and glucose tolerance; conversely expanded visceral fat [VAT] is associated with insulin resistance, low grade inflammation, dyslipidaemia and cardiometabolic risk. The largest depot, subc...
76 CitationsSource
#1Sandra K. HunterH-Index: 32
#2Jeanette M. ThomH-Index: 26
Last.Régis MatranH-Index: 26
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#1Katherine T. Tonks (Garvan Institute of Medical Research)H-Index: 7
Last.Dorit Samocha-Bonet (Garvan Institute of Medical Research)H-Index: 21
view all 5 authors...