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Donald J. Chisholm
Garvan Institute of Medical Research
224Publications
62H-index
18.1kCitations
Publications 224
Newest
Published on May 8, 2019in Journal of Clinical Medicine
Alice Tang1
Estimated H-index: 1
,
Adelle C. F. Coster17
Estimated H-index: 17
+ 11 AuthorsAimin Xu68
Estimated H-index: 68
Background: Large cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing in older age. We aimed to assess the fate of insulin sensitivity per se over time in overweight and obese individuals. Methods: Individuals studied using the hyperinsulinaemic-euglycaemic clamp at the Garvan Institute of Medical Research from 2008 to 2010 (n = 99) were retrospectively grouped into Lean (body mass index (BMI) < 25 kg/m2) or overwe...
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Published on Jan 1, 2019in Obesity Research & Clinical Practice 2.06
Ramy H. Bishay3
Estimated H-index: 3
,
Katherine Tonks6
Estimated H-index: 6
+ 4 AuthorsJerry R. Greenfield35
Estimated H-index: 35
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Published on Apr 1, 2016in Obesity 3.97
Katherine Tonks6
Estimated H-index: 6
,
Adelle C. F. Coster17
Estimated H-index: 17
+ 8 AuthorsJerry R. Greenfield35
Estimated H-index: 35
Objective Alterations in lipids in muscle and plasma have been documented in insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear. Methods Nondiabetic sedentary individuals not treated with lipid-lowering medications were studied (n = 51). Subjects with body mass index (BMI) > 25 kg/m2 (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic-euglycemic clamp into insulin-sensitive ...
51 Citations Source Cite
Published on Jan 1, 2016
Edward W. Kraegen1
Estimated H-index: 1
,
Gregory J. Cooney53
Estimated H-index: 53
+ 4 AuthorsDonald J. Chisholm62
Estimated H-index: 62
Published on Nov 1, 2015in The Journal of Clinical Endocrinology and Metabolism 5.61
Daniel L.T Chen2
Estimated H-index: 2
,
Carsten Liess3
Estimated H-index: 3
(Philips)
+ 9 AuthorsDonald J. Chisholm62
Estimated H-index: 62
Context: Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. Objective: We examined phenotypic and metabolic factors associated with insulin sensitivity in both muscle and liver in obese individuals. Design and Participants: Sixty-four nondiabetic obese adults (29 males) underwent hyperinsulinemic (15 and 80 mU/m2 · min)-euglycemic clamps with deuterated glucose. Top tertile subjects for glucose infusion rate during the high-dose insulin clamp were as...
20 Citations Source Cite
Published on Mar 24, 2015in Nutrients 4.17
Dorit Samocha-Bonet20
Estimated H-index: 20
,
Donald J. Chisholm62
Estimated H-index: 62
+ 1 AuthorsJerry R. Greenfield35
Estimated H-index: 35
l-glutamine triggers glucagon-like peptide-1 (GLP-1) release from L cells in vitro and when ingested pre-meal, decreases postprandial glycaemia and increases circulating insulin and GLP-1 in type 2 diabetes (T2D) patients. We aimed to evaluate the effect of oral l-glutamine, compared with whole protein low in glutamine, on insulin response in well-controlled T2D patients. In a randomized study with a crossover design, T2D patients (n = 10, 6 men) aged 65.1 ± 5.8, with glycosylated hemoglobin (Hb...
5 Citations Source Cite
Published on Jan 30, 2015in Frontiers in Endocrinology 3.63
Xiuquan Ma5
Estimated H-index: 5
(USYD: University of Sydney),
Paul Lee13
Estimated H-index: 13
(Garvan Institute of Medical Research)
+ 1 AuthorsDavid E. James80
Estimated H-index: 80
(USYD: University of Sydney)
Adipocyte differentiation and its impact on restriction or expansion of particular adipose tissue depots has physiological and pathophysiological significance in view of the different functions of these depots. Brown or “beige” fat [BAT] expansion can enhance thermogenesis, lipid oxidation, insulin sensitivity and glucose tolerance; conversely expanded visceral fat [VAT] is associated with insulin resistance, low grade inflammation, dyslipidaemia and cardiometabolic risk. The largest depot, subc...
70 Citations Source Cite
Published on Jan 1, 2015
Sandra K. Hunter33
Estimated H-index: 33
,
Jeanette M. Thom25
Estimated H-index: 25
+ 18 AuthorsM. J. McKenna
Published on Dec 1, 2014in Obesity Research & Clinical Practice 2.06
Katherine Tonks6
Estimated H-index: 6
(Garvan Institute of Medical Research),
Christopher White12
Estimated H-index: 12
+ 2 AuthorsDorit Samocha-Bonet20
Estimated H-index: 20
(Garvan Institute of Medical Research)
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