Anna L. David
University College London
Publications 355
#1Panicos Shangaris (UCL: University College London)H-Index: 7
#2Stavros P. Loukogeorgakis (ICH: UCL Institute of Child Health)H-Index: 20
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 23 authors...
In utero gene therapy (IUGT) to the fetal hematopoietic compartment could be used to treat congenital blood disorders such as β-thalassemia. A humanised mouse model of β-thalassemia was used, in which heterozygous animals are anaemic with splenomegaly and extramedullary hematopoiesis. Intrahepatic in utero injections of a β globin-expressing lentiviral vector (GLOBE), were performed in fetuses at E13.5 of gestation. We analysed animals at 12 and 32 weeks of age, for vector copy number in bone ma...
#1Merryl Harvey (BCU: Birmingham City University)H-Index: 6
#2Anna L. David (UCL: University College London)H-Index: 30
Last.Rebecca Spencer (UCL: University College London)H-Index: 4
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Background The EVERREST Prospective Study is a multicentre observational cohort study of pregnancies affected by severe early-onset fetal growth restriction. The study recruits women with singleton pregnancies where the estimated fetal weight is less than the 3rd centile and below 600 g, between 20 + 0 and 26 + 6 weeks of pregnancy, in the absence of a known chromosomal, structural or infective cause.
#1Filipa Vlahova (UCL: University College London)H-Index: 3
#2Kate E. Hawkins (UCL: University College London)H-Index: 3
Last.Pascale V. Guillot (UCL: University College London)H-Index: 4
view all 9 authors...
Expression of OCT4A is one of the hallmarks of pluripotency, defined as a stem cell’s ability to differentiate into all the lineages of the three germ layers. Despite being defined as non-tumorigenic cells with high translational potential, human mid-trimester amniotic fluid stem cells (hAFSCs) are often described as sharing features with embryonic stem cells, including the expression of OCT4A, which could hinder their clinical potential. To clarify the OCT4A status of hAFSCs, we first undertook...
#1Rosalind Aughwane (UCL: University College London)H-Index: 3
Last.Anna L. David (UCL: University College London)H-Index: 30
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Abstract Introduction There are considerable variations in villous morphology within a normal placenta. However, whether there is a reproducible spatial pattern of variation in villous vascular density is not known. Micro-CT provides three-dimensional volume imaging with spatial resolution down to the micrometer scale. In this study, we applied Micro-CT and histological analysis to investigate the degree of heterogeneity of vascularisation within the placenta. Method Ten term placentas were coll...
#1David W. Barrett (QMUL: Queen Mary University of London)H-Index: 1
#2Rebecca K. John (QMUL: Queen Mary University of London)
Last.Tina T. Chowdhury (QMUL: Queen Mary University of London)H-Index: 16
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Mechanical and inflammatory signals in the fetal membrane play an important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth. We developed a mechanical model that mimics repetitive stretching of the amniotic membrane (AM) isolated from regions over the placenta (PAM) or cervix (CAM) and examined the effect of cyclic tensile strain (CTS) on mediators involved in mechanotransduction (Cx43, AKT), tissue remodelling (GAGs, elastin, collagen) and inflammation (PG...
#1Tina T. ChowdhuryH-Index: 16
#2David W. BarrettH-Index: 1
Last.Anna L. DavidH-Index: 30
view all 3 authors...
#1Efthymios Maneas (UCL: University College London)H-Index: 7
#2Rosalind Aughwane (UCL: University College London)H-Index: 3
Last.Adrien E. Desjardins (UCL: University College London)H-Index: 23
view all 16 authors...
#1Dimitra Flouri ('KCL': King's College London)H-Index: 1
#2David Owen ('KCL': King's College London)H-Index: 1
Last.Andrew Melbourne ('KCL': King's College London)H-Index: 1
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The placenta plays a key contribution to successful pregnancy outcome. New MR imaging techniques are able to reveal intricate details about placental structure and function and measure placental blood flow and feto-placental oxygenation. Placental diffusion-weighted MRI is however challenging due to maternal breathing motion and poor signal-to-noise ratio making motion correction important for subsequent quantitative analysis. In this work, we (i) introduce an iterative model-based registration ...