Anna L. David
University College London
Genetic enhancementObstetricsFetusPregnancyMedicine
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Publications 379
#1Dimitra Flouri (UCL: University College London)H-Index: 1
#2David Owen (UCL: University College London)H-Index: 7
Last. Andrew Melbourne (UCL: University College London)H-Index: 12
view all 13 authors...
PURPOSE: Motion correction in placental DW-MRI is challenging due to maternal breathing motion, maternal movements, and rapid intensity changes. Parameter estimates are usually obtained using least-squares methods for voxel-wise fitting; however, they typically give noisy estimates due to low signal-to-noise ratio. We introduce a model-driven registration (MDR) technique which incorporates a placenta-specific signal model into the registration process, and we present a Bayesian approach for Diff...
1 CitationsSource
#1Teresa Tropea (University of Manchester)H-Index: 3
#2Lewis Renshall (University of Manchester)H-Index: 5
Last. Susan L. Greenwood (University of Manchester)H-Index: 29
view all 12 authors...
KEY POINTS: Maternal hypertension is associated with increased rates of pregnancy pathologies, including fetal growth restriction, due at least in part to reductions in nitric oxide (NO) bioavailability and associated vascular dysfunction. Dietary nitrate supplementation, from beetroot juice (BRJ), has been shown to increase NO bioavailability and improve cardiovascular function in both preclinical and clinical studies. This study is the first to investigate effects of dietary nitrate supplement...
#1Helen Carnaghan (ICH: UCL Institute of Child Health)H-Index: 4
#2Cp James (UCLH: University College Hospital)H-Index: 1
Last. Prakesh Shah (U of T: University of Toronto)H-Index: 45
view all 14 authors...
OBJECTIVE: In gastroschisis, there is evidence to suggest that gut dysfunction develops secondary to bowel inflammation; we aimed to evaluate the effect of maternal antenatal corticosteroids administered for obstetric reasons on time to full enteral feeds in a multicenter cohort study of gastroschisis infants. METHODS: A three center, retrospective cohort study (1992-2013) with linked fetal/neonatal gastroschisis data was conducted. The primary outcome measure was time to full enteral feeds (a s...
#1Natalie J. Hannan (Mercy Hospital for Women)H-Index: 28
#2Owen M Stock (Mercy Hospital for Women)H-Index: 9
Last. Sean K.M. SeehoH-Index: 8
view all 20 authors...
BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placental insufficiency with a high risk of stillbirth. We set out to identify maternal circulating mRNA transcripts that are differentially expressed in preterm pregnancies complicated by very severe placental insufficiency, in utero fetal acidemia, and are at very high risk of still...
#1Adalina Sacco (UCL: University College London)H-Index: 2
#2Shahanaz Ahmed (UCL: University College London)H-Index: 1
Last. Anna L. David (UCL: University College London)H-Index: 30
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AbstractFoetal surgery to repair open spina bifida before birth improves infant motor function and reduces ventriculoperitoneal shunt requirement. Alongside the development of the first UK foetal s...
1 CitationsSource
Abstract Objectives Cervical cerclage is used to manage women at high risk of late miscarriage (LM) and spontaneous preterm birth (PTB) due to factors such as history of cervical insufficiency (CI), uterine anomaly, cervical surgery and ultrasound (US) diagnosed cervical shortening. Urinary tract infection (UTI) and subsequent pyelonephritis, and bacterial infection are associated with PTB, but their role in PTB after cervical cerclage is unknown. We examined the relationship between UTI and bac...
#1May Zaw Thin (UCL: University College London)
#2Olumide Ogunlade (UCL: University College London)H-Index: 9
Last. Tammy L. Kalber (UCL: University College London)H-Index: 11
view all 9 authors...
Cell-based therapies are promising treatments for various kidney diseases. However, the major hurdle in initiating therapeutic responses is the inefficiency of injection routes to deliver cells to the kidney parenchyma. Systemic injection, such as intravenous injection only delivers a small proportion of cells to the kidney. Whereas direct delivery, such as renal artery injection requires surgical procedures. A minimally invasive renal artery injection was therefore developed to enhance cell del...
#1Jan DeprestH-Index: 66
#2Marc Van Ranst (Katholieke Universiteit Leuven)H-Index: 59
Last. Tim Van Mieghem (U of T: University of Toronto)H-Index: 6
view all 8 authors...
Even though the global COVID-19 pandemic may affect how medical care is delivered in general, most countries try to maintain steady access for women to routine pregnancy care, including fetal anomaly screening. This means that, also during this pandemic, fetal anomalies will be detected, and that discussions regarding invasive genetic testing and possibly fetal therapy will need to take place. For patients, concerns about Severe Acute Respiratory Syndrome-Corona Virus 2 (SARS-CoV2) will add to t...
#1Efthymios Maneas (UCL: University College London)H-Index: 7
#2Rosalind Aughwane (UCL: University College London)H-Index: 3
Last. Adrien E. Desjardins (UCL: University College London)H-Index: 23
view all 16 authors...
: Minimally invasive fetal interventions require accurate imaging from inside the uterine cavity. Twin-to-twin transfusion syndrome (TTTS), a condition considered in this study, occurs from abnormal vascular anastomoses in the placenta that allow blood to flow unevenly between the fetuses. Currently, TTTS is treated fetoscopically by identifying the anastomosing vessels, and then performing laser photocoagulation. However, white light fetoscopy provides limited visibility of placental vasculatur...
4 CitationsSource
#1Bilal Mateen (University of Cambridge)H-Index: 1
#2Anna L. David (UCL: University College London)H-Index: 30
Last. Spiros DenaxasH-Index: 23
view all 3 authors...
Gestational diabetes mellitus is a common pregnancy complication associated with significant adverse health outcomes for both women and infants. Effective screening and early prediction tools as part of routine clinical care are needed to reduce the impact of the disease on the baby and mother. Using large-scale electronic health records, Artzi and colleagues developed and evaluated a machine learning driven tool to identify women at high and low risk of GDM. Their findings showcase how artifici...