Amit Khera
University of Texas Southwestern Medical Center
EndocrinologyCardiologyPopulationDiabetes mellitusMedicine
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Publications 411
#1Krishna G. Aragam (MIT: Massachusetts Institute of Technology)H-Index: 11
#2Amanda Dobbyn (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
Last. Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 28 authors...
Abstract Background Polygenic risk scores (PRS) for coronary artery disease (CAD) identify high-risk individuals more likely to benefit from primary prevention statin therapy. Whether polygenic CAD risk is captured by conventional paradigms for assessing clinical cardiovascular risk remains unclear. Objectives This study sought to intersect polygenic risk with guideline-based recommendations and management patterns for CAD primary prevention. Methods A genome-wide CAD PRS was applied to 47,108 i...
1 CitationsSource
#1Amit Khera (Broad Institute)H-Index: 52
#2Robert A. Hegele (UWO: University of Western Ontario)H-Index: 84
#1Ryan L. Collins (Broad Institute)H-Index: 18
#2Harrison Brand (Broad Institute)H-Index: 18
Last. Harold Z. Wang (Broad Institute)H-Index: 4
view all 46 authors...
Structural variants (SVs) rearrange large segments of DNA1 and can have profound consequences in evolution and human disease2,3. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD)4 have become integral in the interpretation of single-nucleotide variants (SNVs)5. However, there are no reference maps of SVs from high-coverage genome sequencing co...
6 CitationsSource
#2Gani Bajraktari (Umeå University)H-Index: 15
Last. Maciej Banach (University of Zielona Góra)H-Index: 47
view all 76 authors...
Summary Proteins play a crucial role in metabolism, in maintaining fluid and acid-base balance and antibody synthesis. Dietary proteins are important nutrients and are classified into: 1) animal proteins (meat, fish, poultry, eggs and dairy), and, 2) plant proteins (legumes, nuts and soy). Dietary modification is one of the most important lifestyle changes that has been shown to significantly decrease the risk of cardiovascular (CV) disease (CVD) by attenuating related risk factors. The CVD burd...
#1Kavisha Singh (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Alvin Chandra (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
Last. Eke G. Gruppen (UMCG: University Medical Center Groningen)H-Index: 9
view all 13 authors...
Background: High density lipoprotein cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle concentration (HDL...
#1Gopal P. Sarma (Broad Institute)H-Index: 6
#2Erik Reinertsen (MIT: Massachusetts Institute of Technology)H-Index: 6
Last. Connor A. EmdinH-Index: 2
view all 23 authors...
The intersection of medicine and machine learning (ML) has the potential to transform healthcare. We describe how physiology, a foundational discipline of medical training and practice with a rich quantitative history, could serve as a starting point for the development of a common language between clinicians and ML experts, thereby accelerating real-world impact.
#1H. Wand (Johns Hopkins University)H-Index: 1
#2Samuel A. Lambert (University of Cambridge)H-Index: 1
Last. E. Venner (BCM: Baylor College of Medicine)H-Index: 1
view all 32 authors...
Over the past decade, genome-wide association studies have identified genetic variation associated with a wide range of human diseases and traits. These findings are now commonly aggregated into polygenic risk scores, which can bridge the gap between the initial discovery efforts and clinical applications for disease risk estimation. However, there is remarkable heterogeneity in the reporting of these risk scores due to a lack of accepted standards for the development, reporting, and application...
2 CitationsSource
#1James P. Pirruccello (Broad Institute)H-Index: 11
#2Alexander G. Bick (Broad Institute)H-Index: 19
Last. Wendy S. Post (Johns Hopkins University)H-Index: 62
view all 19 authors...
Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been associated with DCM, but common variant studies of the disease have yielded few associated loci. As structural changes in the heart are a defining feature of DCM, we report a genome-wide association study of cardiac magnetic resonance imaging (MRI)-derived left ventricular measurements in 36,041 UK Biobank participants, with replication in...
1 CitationsSource
#1Aniruddh P. Patel (Harvard University)H-Index: 5
#2Manish D. Paranjpe (Harvard University)H-Index: 2
Last. Amit Khera (Harvard University)H-Index: 52
view all 5 authors...
Preliminary reports suggest that the Coronavirus Disease 2019 (COVID−19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. The extent to which these disparities are related to socioeconomic versus biologic factors is largely unknown. We investigate the racial and socioeconomic associations of COVID−19 hospitalization among 418,794 participants of the UK Biobank, of whom 549 (0.13%) had been hospitalized. Both black participants (odds ratio...
2 CitationsSource
#1Niki KatsikiH-Index: 32
#1Niki Katsiki (AHEPA University Hospital)H-Index: 4
Last. Željko ReinerH-Index: 51
view all 72 authors...
Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevati...