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Jiawei Chen
Fudan University
28Publications
10H-index
240Citations
Publications 28
Newest
#1Yue Zhang (Fudan University)
#2Xiaowei Ding (Fudan University)H-Index: 2
Last.Jiawei Chen (Fudan University)H-Index: 10
view all 4 authors...
Background The levels of tight junction proteins (TJs), especially occludin, correlate with blood-brain barrier (BBB) disruption caused by inflammation in central nervous system (CNS). It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS. In this study, we investigated the effects of tumor necrosis factor-α (TNF-α) and propofol on occludin expression in human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), and ...
#1Xiaowei Ding (Fudan University)H-Index: 2
#2Xia Sun (Fudan University)H-Index: 2
Last.Jiawei Chen (Fudan University)H-Index: 10
view all 8 authors...
Metalloproteinase 9 (MMP-9) is able to degrade collagen IV, an important component of blood–brain barrier (BBB). Expression of MMPs, especially MMP-9, correlates with BBB disruption during central nervous system inflammation. Propofol has been reported to have anti-inflammation effects. In this study, we investigated the effects of propofol on TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells (hCMEC/D3 cells) and explored the underlying mechanisms. The hCMEC/D3 cel...
#1Xia Sun (Fudan University)H-Index: 2
#2YueHao Yin (Fudan University)
Last.Jiawei Chen (Fudan University)H-Index: 10
view all 6 authors...
Heat shock proteins (HSPs) may be induced by hypoxia and alleviate blood–brain barrier (BBB) damage. The neuroprotective effect of propofol has been reported. We aimed to identify whether propofol induced HSPs expression and protected BBB integrity. Mouse astrocytes and microglia cells were cultured and exposed to hypoxia and propofol. The expression of HSP27, HSP32, HSP70, and HSP90, and the translocation of heat shock factor 1 (HSF1) and Nuclear factor-E2-related factor 2 (Nrf2) were investiga...
#1Wei Chen (Fudan University)H-Index: 3
#2Xing‐Zhu Ju (Fudan University)
Last.Jiawei Chen (Fudan University)H-Index: 10
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AIMS:Hypoxia may damage blood-brain barrier (BBB). The neuroprotective effect of propofol has been reported. We aimed to identify whether and how propofol improved hypoxia-induced impairment of BBB integrity. METHODS:Mouse brain microvascular endothelial cells (MBMECs) and astrocytes were cocultured to establish in vitro BBB model. The effects of hypoxia and propofol on BBB integrity were examined. Further, zonula occludens-1 (ZO-1) expression and phosphorylation, hypoxia-inducible factor-1α (HI...
#1Xiaowei Ding (Fudan University)H-Index: 2
#2Xing‐Zhu Ju (Fudan University)
Last.Jiawei Chen (Fudan University)H-Index: 10
view all 7 authors...
Purpose Angiotensin II (Ang II) has been shown to be involved in neurological disorders. Propofol demonstrated neuroprotective effects in neurons.
#1Jiaqiang Wang (Fudan University)H-Index: 3
#2Chien-shan Cheng (Fudan University)
Last.Jiawei Chen (Fudan University)H-Index: 10
view all 7 authors...
Abstract Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. This review focused on the findings within the past ten years a...
#1Yan Lu (Fudan University)H-Index: 1
#2Wei Chen (Fudan University)H-Index: 3
Last.Changhong Miao (Fudan University)H-Index: 8
view all 7 authors...
Perioperative cerebral ischemia/hypoxia could induce hippocampal injury and has been reported to induce cognitive impairment. In this study, we used cobalt chloride (CoCl2) to build a hypoxia model in mouse hippocampal cell lines. Propofol, a widely used intravenous anesthetic agent, has been demonstrated to have neuroprotective effect. Here, we explored whether and how propofol attenuated CoCl2-induced mouse hippocampal HT22 cell injury. Mouse hippocampal HT22 cells were pretreated with propofo...
#1Zheng Xu (Fudan University)H-Index: 1
#2Yan Lu (Fudan University)H-Index: 9
Last.Changhong Miao (Fudan University)H-Index: 8
view all 6 authors...
Abstract Aim Inflammation cytokine tumor necrosis factor-α (TNF-α) induces apoptosis in neuronal cells. We hypothesized that propofol may attenuate TNF-α-induced apoptosis in mouse hippocampal HT22 cells and aimed to explore the underlying mechanisms. Methods Mouse hippocampal HT22 cells were pretreated with propofol, and then stimulated with TNF-α. Cell viability was measured by cell counting kit 8 (CCK8). Cell apoptosis was examined by flow cytometry analysis. The effect of propofol on TNF-α-m...
#1Yan Lu (Fudan University)H-Index: 9
#2Yuechao Gu (Fudan University)H-Index: 1
Last.Changhong Miao (Fudan University)H-Index: 8
view all 6 authors...
Background Perioperative hypoxia may induce microglial inflammation and apoptosis, resulting in brain injury. The neuroprotective effect of propofol against hypoxia has been reported, but the underlying mechanisms are far from clear. In this study, we explored whether and how propofol could attenuate microglia BV2 cells from CoCl2-induced hypoxic injury. Methods Mouse microglia BV2 cells were pretreated with propofol, and then stimulated with CoCl2. TNF-α level in the culture medium was measured...
#1Zhirong Sun (Fudan University)H-Index: 2
#2Anrong Mao (Fudan University)H-Index: 1
Last.Changhong Miao (Fudan University)H-Index: 8
view all 7 authors...
Abstract Millions of patients benefit from surgery and are exposed to surgical stress. However, ample studies suggest that surgical stress contributes to tumor recurrence or distant metastases. Surgical stress suppresses CD8+ T cells (CTL) function which is vital for eliminating the malignant cells. Anti-programmed cell death 1 (PD-1) therapy is an effective and safe treatment that increases survival rate of patients with multiple cancers, however, whether anti-PD-1 therapy is able to reverse th...
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