Wolfgang L. Gross
University of Lübeck
PathologyImmunologyAnti-neutrophil cytoplasmic antibodyVasculitisMedicine
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Publications 488
#1Limy Wong (University of Cambridge)H-Index: 1
#2Federica Mescia (University of Cambridge)H-Index: 1
Last. Kenneth G. C. Smith (University of Cambridge)H-Index: 66
view all 47 authors...
#1Jan H. SchirmerH-Index: 5
#2Marvin N. Wright (University of Lübeck)H-Index: 11
Last. Julia U. HolleH-Index: 24
view all 13 authors...
To evaluate the clinical presentation and long-term outcome of a vasculitis centre cohort of patients with microscopic polyangiitis (MPA) with respect to organ manifestations, treatment, chronic damage and mortality.We performed a retrospective chart review at our vasculitis referral centre. MPA patients admitted between 1991 and 2013 classified by a modified European Medicines Agency algorithm were diagnosed and treated according to a standardized interdisciplinary approach.Comprehensive data f...
22 CitationsSource
#1Matthieu Groh (Paris V: Paris Descartes University)H-Index: 13
#2Christian Pagnoux (U of T: University of Toronto)H-Index: 32
Last. Loïc Guillevin (Paris V: Paris Descartes University)H-Index: 94
view all 23 authors...
Abstract Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the mee...
129 CitationsSource
Anti-neutrophil cytoplasmic autoantibodies (ANCA) with specificity for proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are a defining feature of ANCA-associated vasculitides (AAV). They play a pivotal role in disease pathophysiology and have strongly improved early diagnosis and treatment of these infrequent, but potentially fatal diseases. Neutrophils and their products are major players in initiating the autoimmune response and tissue destruction in vasculitic as well as granulomatous in...
25 CitationsSource
#1Glen Hazlewood (U of C: University of Calgary)H-Index: 14
#2Metzler C (University of Lübeck)H-Index: 9
Last. Christian Pagnoux (U of T: University of Toronto)H-Index: 32
view all 7 authors...
Abstract Objective To determine the comparative efficacy of non-biologic treatments for remission maintenance in ANCA-associated vasculitis. Methods We identified all randomized trials comparing leflunomide, azathioprine, methotrexate or mycophenolate mofetil in adult patients with granulomatosis with polyangiitis or microscopic polyangiitis. Relapse-free survival was compared through hazard ratios (HR) using a Bayesian fixed-effects network meta-analysis. Multiple sensitivity analyses were perf...
16 CitationsSource
#1Glen HazlewoodH-Index: 14
#2Metzler CH-Index: 9
Last. Christian Pagnoux (U of T: University of Toronto)H-Index: 32
view all 7 authors...
Resume Objectif Determiner l’efficacite comparative des traitements non biologiques dans le maintien de la remission dans les vascularites a ANCA. Methodes Nous avons identifie tous les essais cliniques comparant le leflunomide, l’azathioprine, le methotrexate ou le mycophenolate mofetil chez les patients atteints d’une granulomatose avec polyangeite ou d’une polyangeite microscopique. La survie sans rechute a ete comparee en calculant les hazard ratios (HR) en utilisant une meta-analyse en rese...
#1R.S. Philipson (GSK: GlaxoSmithKline)
#2J. Anderson (GSK: GlaxoSmithKline)
Last. Michael E. WechslerH-Index: 42
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Background A double-blind, randomised, placebo-controlled, 60-week study of mepolizumab (300 mg every 4 weeks) in eosinophilic granulomatosis with polyangiitis (EGPA) is being sponsored by GlaxoSmithKline in collaboration with the National Institute of Allergy and Infectious Diseases (NIH) in the US. It is critical to ensure definition of the appropriate EPGA diagnostic criteria and study outcomes for this global study. Objectives To present the study design, criteria for selection of the study ...
#1Karen HerlynH-Index: 22
#2Frederike BuckertH-Index: 1
Last. Eva Reinhold-KellerH-Index: 31
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Objectives. The aim of this study was to investigate the period prevalences of ANCA-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic GPA (EGPA)/ChurgStrauss and GCA, in an urban and rural population in northern Germany in 2006 and to compare the data with our previous study performed in 1994. Methods. We identified of all patients with AAV or GCA via questionnaires to all hospital departments, physicians, health insuran...
34 CitationsSource
#1Stefan Wieczorek (RUB: Ruhr University Bochum)H-Index: 28
#2Julia U. HolleH-Index: 24
Last. Jörg T. Epplen (RUB: Ruhr University Bochum)H-Index: 69
view all 7 authors...
10 CitationsSource
#1Peter LamprechtH-Index: 32
Last. Wolfgang L. GrossH-Index: 76
view all 3 authors...
2 CitationsSource