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Brian K. Lee
Drexel University
PsychiatryAutismPopulationMedicineCohort
85Publications
26H-index
2,558Citations
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Publications 90
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#1Daniel J. Tward (Johns Hopkins University)H-Index: 16
Last. Partha P. MitraH-Index: 53
view all 6 authors...
Mapping information from different brains gathered using different modalities into a common coordinate space corresponding to a reference brain is an aspirational goal in modern neuroscience, analogous in importance to mapping genomic data to a reference genome. While brain-atlas mapping workflows exist for single-modality data (3D MRI or STPT image volumes), generally speaking data sets need to be combined across modalities with different contrast mechanisms and scale, in the presence of missin...
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#1Dina Terloyeva (Drexel University)H-Index: 1
#2Alexander J. Frey (Drexel University)H-Index: 4
Last. Margaret Daniele Fallin (Johns Hopkins University)H-Index: 20
view all 14 authors...
Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid and cord blood, with mixed results. To provide an orthogonal measure of fetal exposure, this study used meconium, the first stool of a newborn, to measure prenatal androgen exposure from infants in the Early Autism Risk Longitudinal Investigation (EARLI). EARLI is a familial-enriched risk cohort that enroll...
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#1Renee M. Gardner (KI: Karolinska Institutet)H-Index: 19
#2Christina Dalman (KI: Karolinska Institutet)H-Index: 36
Last. Håkan Karlsson (KI: Karolinska Institutet)H-Index: 30
view all 5 authors...
Objective Original case descriptions of autism noted that parents of the affected children tended to be highly educated and intelligent, a characterization that has endured publicly. Recent genetic studies indicate that risk for autism spectrum disorders (ASD) is associated with high intelligence. We examined the association between paternal intelligence and ASD, considering co-occurring intellectual disability (ID) and attention-deficit/hyperactivity disorder (ADHD). Method We used a register-b...
2 CitationsSource
In January 2017, Philadelphia (Pennsylvania) implemented an excise tax ($ 0.015/ounce) on sugar-sweetened and diet beverages. This study is a general population-based study to report on the longer-term impacts of the tax on within-person changes in consumption 12 months after implementation. A quasi-experimental difference-in-difference design was used to contrast Philadelphia vs. nearby comparison cities (Trenton, New Jersey; Camden, New Jersey; and Wilmington, Delaware) at baseline (December 2...
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#1Renee M. Gardner (KI: Karolinska Institutet)H-Index: 19
#2Brian K. Lee (Drexel University)H-Index: 26
Last. Håkan Karlsson (KI: Karolinska Institutet)H-Index: 30
view all 6 authors...
Background: Immune signaling pathways influence neurodevelopment and are hypothesized to contribute to the etiology of autism spectrum disorders (ASD). We aimed to assess risk of ASD in relation to levels of neonatal acute phase proteins, key components of innate immune function, measured in neonatal dried blood spots. Method: We included 924 ASD cases, 1092 unaffected population-based controls, and 203 unaffected siblings to ASD cases in this case-control study nested within the register-based ...
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#1Daniel T. Vader (Drexel University)
#2Brian K. Lee (Drexel University)H-Index: 26
Last. Alison A. Evans (Drexel University)H-Index: 23
view all 3 authors...
Introduction The Advisory Committee on Immunization Practices recommends administering the first dose of hepatitis B vaccine at birth, making it the first vaccine that many children receive. However, few studies examine whether children who miss the birth dose are at increased risk of vaccination delay. This study investigates birth dose as a determinant of up-to-date immunization status at age 18 months, considering 7 core childhood vaccine series: diphtheria, tetanus, and acellular pertussis; ...
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#1Aline Marileen Wiegersma (KI: Karolinska Institutet)H-Index: 1
#2Christina Dalman (KI: Karolinska Institutet)H-Index: 36
Last. Renee M. Gardner (KI: Karolinska Institutet)H-Index: 19
view all 5 authors...
Importance Given the critical role that iron plays in neurodevelopment, an association between prenatal iron deficiency and later risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), is plausible. Objective To test the a priori hypothesis that anemia diagnosed in mothers during pregnancy is associated with an increased risk of ASD, ADHD, and ID in offspring and that the magnitude of the ri...
4 CitationsSource
#1Brian K. Lee (KI: Karolinska Institutet)H-Index: 26
#2Darryl W. Eyles (UQ: University of Queensland)H-Index: 50
Last. Renee M. Gardner (KI: Karolinska Institutet)H-Index: 19
view all 10 authors...
Animal studies indicate that early life vitamin D is crucial for proper neurodevelopment. Few studies have examined whether maternal and neonatal vitamin D concentrations influence risk of autism spectrum disorders (ASD). Participants were sampled from the Stockholm Youth Cohort, a register-based cohort in Sweden. Concentrations of total 25-hydroxyvitamin D (25OHD) were assessed from maternal and neonatal biosamples using a highly sensitive liquid chromatography tandem mass spectrometry method. ...
3 CitationsSource
#1Chen Wang (KI: Karolinska Institutet)
#2Isabelle Le Ray (KI: Karolinska Institutet)H-Index: 1
Last. Mary M. Reilly (KI: Karolinska Institutet)H-Index: 60
view all 5 authors...
The increased risk of venous thromboembolism (VTE) associated with pregnancy is well-known and prophylaxis guidelines consider a number of risk factors. Although non-O blood group and red blood cell (RBC) transfusion are known to be associated with VTE risk, their contribution to pregnancy-associated VTE has received little attention. This study was conducted in a population-based cohort of 1,000,997 deliveries to women with no prior history of VTE or thrombophilia. The independent contributions...
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#1Brian K. Lee (Drexel University)H-Index: 26
#2Raz Gross (TAU: Tel Aviv University)H-Index: 7
Last. Sven Sandin (KI: Karolinska Institutet)H-Index: 38
view all 12 authors...
Season of birth has been hypothesized to be a risk factor for autism spectrum disorder (ASD). However, the evidence has been mixed and limited due to methodological challenges. We examine ASD birth trends for 5,464,628 births across 5 countries. ASD birth prevalence data were obtained from the International Collaboration for Autism Registry Epidemiology database, including children born in Denmark, Finland, Norway, Sweden, and Western Australia. Empirical mode decomposition and cosinor modeling ...
1 CitationsSource
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