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Steven S. Geier
Temple University
AntibodyHuman leukocyte antigenImmunologyMedicineBiology
22Publications
2H-index
13Citations
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Publications 22
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#1Steven S. Geier (TU: Temple University)H-Index: 2
#2Olga A. Timofeeva (TU: Temple University)H-Index: 2
Last. Francis Cordova (TU: Temple University)H-Index: 19
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#1Yanping Huang (Children's Hospital of Philadelphia)H-Index: 2
#2Anh Dinh (Children's Hospital of Philadelphia)H-Index: 2
Last. Dimitri S. Monos (UPenn: University of Pennsylvania)H-Index: 34
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2 CitationsSource
#1Stacey BrannH-Index: 1
#2Steven S. GeierH-Index: 2
Last. Yoshiya ToyodaH-Index: 36
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#1Steven S. Geier (TU: Temple University)H-Index: 2
#2Leena Mathew (TU: Temple University)
Last. Olga Timofeeva (TU: Temple University)H-Index: 17
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Aim The accuracy of HLA antibody testing is very important for entering UNOS Unacceptable donor antigens, evaluating organ offers by virtual and prospective crossmatch, and evaluating donor specific antibodies (DSAs) pre and post transplant. It is known that Single Antigen Beads (SAB) often have problems with false positive reactions, when the manufacturing process results in 3–5% denatured HLA determinants on every bead, exposing cryptic, non HLA antigens. This case study demonstrates that SAB ...
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#1Olga Timofeeva (TU: Temple University)H-Index: 17
#2Steven S. Geier (TU: Temple University)H-Index: 2
Last. Yoshiya Toyoda (TU: Temple University)H-Index: 36
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Aim Virtual crossmatch (VXM) has increased non-local organ utilization and improved clinical outcomes for sensitized lung patients. However, the concordance between VXM and cell-based crossmatch is not absolute because Single Antigen Bead (SAB) assay is prone to both false-negative and false-positive reactions. Since false-positive antibody specificities may unnecessarily deny an organ based on VXM, the goal of this study was to evaluate what additional testing may be warranted to recognize such...
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#1Steven S. Geier (TU: Temple University)H-Index: 2
#2Josheph Rudic (TU: Temple University)
Last. Olga Timofeeva (TU: Temple University)H-Index: 17
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Aim The accuracy of HLA antibody testing is very important for entering UNOS Unacceptable donor antigens, evaluating organ offers by virtual and prospective crossmatch, and evaluating donor specific antibodies (DSAs) pre and post transplant. It is known that the Single Antigen Bead (SAB) assay can have HLA antibody false positives reactions, due to the exposure of cryptic, non HLA antigens, during the manufacturing process. This study was to determine the SAB false positive rate in our testing a...
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#1Steven S. Geier (TU: Temple University)H-Index: 2
We are disadvantaging pre and post transplant patients who have potential HLA allele donor specific antibodies (DSAs), when deceased donors are not typed an intermediate or high resolution. How can we estimate the antibody mediated rejection risk (AMR), when we can’t tell if an allele antibody is a DSA? With RT-PCR, SSP and rSSO, we have the ability to type donors in 3–6 h at intermediate to near allele level, why isn’t this level required, it is often needed? Forty-eight percent of my kidney wa...
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#1Hemant K. Parekh (TU: Temple University)H-Index: 15
#2Joseph L. Rudic (TU: Temple University)
Last. Steven S. Geier (TU: Temple University)H-Index: 2
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Pre-transplant (txp) sensitization in patients awaiting heart transplants put them at an increased risk post-txp of mortality, rejection, and chronic allograft vasculopathy and also reduces the pool of available donors. Many of the deleterious effects of the HLA antibodies (abs) are associated with their ability to activate the complement cascade. Recent reports have highlighted the correlation between C1q-binding donor-specific HLA abs (DSA) and the increased incidence of antibody-mediated reje...
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#1Phi A. Lai (TU: Temple University)
#2Hemant K. Parekh (TU: Temple University)H-Index: 15
Last. Steven S. Geier (TU: Temple University)H-Index: 2
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Aim To reduce the cost of using RosetteSepTM (RS) Human Total Lymphocyte Enrichment Cocktail (Stemcell Technologies), which improves Flow crossmatch (FC) sensitivity by removing neutrophils and monocytes. Often deceased donor blood neutrophils and monocytes are not completely removed by Ficoll Hypaque (FH) density gradient centrifugation. These cells can compete for patient HLA antibodies. Although RS can remove contaminating cells, the reagent traditionally costs $136.00/FC, this study evaluate...
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