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Tamir Chandra
Western General Hospital
Molecular biologySenescenceGeneticsBiologyCell biology
39Publications
17H-index
1,457Citations
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Publications 46
Newest
#1Bryan R. Conway (Edin.: University of Edinburgh)H-Index: 16
#2Eoin D. O’Sullivan (Edin.: University of Edinburgh)H-Index: 1
Last. Kevin Stewart (Edin.: University of Edinburgh)H-Index: 1
view all 18 authors...
The kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet- and plate- based scRNA-seq in the murine reversible unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single cell level during renal injury and resolution of fibrosis. We generate a comprehensive catalogue of the changes induced during injury and repair, revealing significant myeloid cell heterogen...
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#1Kristina Kirschner (Glas.: University of Glasgow)H-Index: 13
#2Nattaphong Rattanavirotkul (MU: Mahidol University)
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 4 authors...
Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokines from primary senescent cells. More recently, juxtacrine Notch signalling has been implicated in mediating secondary senescence induction. Primary and secondary senescent induction...
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#1Ewa Guzniczak (Heriot-Watt University)H-Index: 1
#2Oliver Otto (University of Greifswald)H-Index: 2
Last. Helen Bridle (Heriot-Watt University)H-Index: 12
view all 8 authors...
Cell-based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product being the cells themselves as opposed to biological molecules such as proteins) and that presents a challenge of developing new robust and economically feasible manufacturing processes, especially for sample purification. Current purification technologies have limited throughput, rely on expensive fluorescent or magnetic immunolabeling with a ...
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#2Futao ZhangH-Index: 12
Last. Archie CampbellH-Index: 24
view all 22 authors...
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#1Stephen Meek (Edin.: University of Edinburgh)H-Index: 14
#2Jun Wei (Edin.: University of Edinburgh)H-Index: 1
Last. Tom Burdon (Edin.: University of Edinburgh)H-Index: 16
view all 11 authors...
Summary Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell pluripotency and self-renewal. Here, we describe an EGFP reporter transgene that tracks expression of the benchmark naive pluripotency marker gene Rex1 (Zfp42) in the rat. Insertion of the EGFP reporter gene downstream of the Rex1 promoter disrupted Rex1 e...
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#2Futao ZhangH-Index: 12
Last. Riccardo E. MarioniH-Index: 40
view all 22 authors...
Availability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to access@generationscotland.org. Full summary statistics for the analyses presented are publicly available online at https://doi.org/10.7488/ds/2709. Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the S...
1 CitationsSource
#1Tom BurdonH-Index: 16
#2Stephen MeekH-Index: 14
Last. Tamir ChandraH-Index: 17
view all 4 authors...
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#1Michael Chiang (Edin.: University of Edinburgh)H-Index: 2
#2Davide Michieletto (University of Bath)H-Index: 10
Last. Tamir Chandra (Western General Hospital)H-Index: 17
view all 7 authors...
Summary Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy, and mass spectrometry to dissect the roles played by heterochromatin- and lamina-mediated interactions in nuclear organization. Our model explains the conventional organization of heterochromatin and euchromatin in growing cells and the pathological organization found in oncogene-indu...
4 CitationsSource
#1Neil A. Robertson (Edin.: University of Edinburgh)H-Index: 1
#2Robert F. Hillary (Edin.: University of Edinburgh)H-Index: 3
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 10 authors...
Summary Age-related clonal haemopoiesis (ARCH) in healthy individuals was initially observed through an increased skewing in X-chromosome inactivation [1] . More recently, several groups reported that ARCH is driven by somatic mutations [2] , with the most prevalent ARCH mutations being in the DNMT3A and TET2 genes, previously described as drivers of myeloid malignancies. ARCH is associated with an increased risk for haematological cancers [2] . ARCH also confers an increased risk for non-haemat...
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#1Michael ChiangH-Index: 2
#2Davide MichielettoH-Index: 10
Last. Tamir ChandraH-Index: 17
view all 7 authors...
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