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Ralph Knöll
AstraZeneca
69Publications
24H-index
2,434Citations
Publications 69
Newest
#1Alba Carreras (Sahlgrenska University Hospital)H-Index: 4
#2Luna Simona PaneH-Index: 2
Last.Marcello MarescaH-Index: 6
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Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, has recently emerged as an approach to reduce cholesterol levels. The development of humanized animal models is an important step to validate and study human drug targets, and use of genome and base editing has been proposed as a mean to target diseas...
1 CitationsSource
#1Maria Carmela Filomena (National Research Council)
#2Daniel L. Yamamoto (National Research Council)H-Index: 1
Last.Marie Louise Bang (National Research Council)H-Index: 20
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#1James W. McNamara (UC: University of Cincinnati)H-Index: 6
#2Jennifer A. Schwanekamp (UC: University of Cincinnati)H-Index: 10
Last.Sakthivel Sadayappan (UC: University of Cincinnati)H-Index: 27
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Source
#1Mohammad Bakhtiar Hossain (KI: Karolinska Institutet)
#2Z Elbeck (KI: Karolinska Institutet)
Last.Ralph Knöll (KI: Karolinska Institutet)H-Index: 24
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Source
#1Ali M. Tabish (KI: Karolinska Institutet)H-Index: 2
#2Mohammed Arif (UC: University of Cincinnati)H-Index: 2
Last.Sakthivel Sadayappan (UC: University of Cincinnati)H-Index: 27
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Our data demonstrate that development of dilated cardiomyopathy in mice is associated with significant epigenetic changes, specifically in intronic regions, which, when combined with gene expressio...
Source
#1Petr G. Vikhorev (NIH: National Institutes of Health)H-Index: 7
#2Natalia Smoktunowicz (NIH: National Institutes of Health)H-Index: 2
Last.Steven B. Marston (NIH: National Institutes of Health)H-Index: 41
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Source
#1Jennifer A. Schwanekamp (UC: University of Cincinnati)H-Index: 10
#2Shiv Kumar Viswanathan (UC: University of Cincinnati)H-Index: 2
Last.Sakthivel Sadayappan (UC: University of Cincinnati)H-Index: 27
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Source
#1Shiv Kumar Viswanathan (LUC: Loyola University Chicago)H-Index: 2
#2Megan J. Puckelwartz (NU: Northwestern University)H-Index: 15
Last.Sakthivel Sadayappan (LUC: Loyola University Chicago)H-Index: 27
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Importance The genetic variant MYBPC3Δ25bp occurs in 4% of South Asian descendants, with an estimated 100 million carriers worldwide. MYBPC3 Δ25bp has been linked to cardiomyopathy and heart failure. However, the high prevalence of MYBPC3Δ25bp suggests that other stressors act in concert with MYBPC3Δ25bp . Objective To determine whether there are additional genetic factors that contribute to the cardiomyopathic expression of MYBPC3Δ25bp . Design, Setting, andParticipants South Asian individuals ...
6 CitationsSource
#1Petr G. Vikhorev (NIH: National Institutes of Health)H-Index: 7
#2Natalia Smoktunowicz (NIH: National Institutes of Health)H-Index: 2
Last.Steven B. Marston (NIH: National Institutes of Health)H-Index: 41
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Dilated cardiomyopathy (DCM) is an important cause of heart failure. Single gene mutations in at least 50 genes have been proposed to account for 25–50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutations in the sarcomeric structural protein titin (TTNtv). Whilst the primary molecular mechanism of some DCM-associated mutations in the contractile apparatus has been studied in vitro and in transgenic mice, the contractile defect in human heart muscle has not bee...
14 CitationsSource
#1Ali M. Tabish (KI: Karolinska Institutet)H-Index: 2
#2Valerio Azzimato (KI: Karolinska Institutet)H-Index: 4
Last.Ralph Knöll (KI: Karolinska Institutet)H-Index: 24
view all 5 authors...
Heart failure (HF) is a complex clinical syndrome defined by the inability of the heart to pump enough blood to meet the body’s metabolic demands. Major causes of HF are cardiomyopathies (diseases of the myocardium associated with mechanical and/or electrical dysfunction), among which the most common form is dilated cardiomyopathy (DCM). DCM is defined by ventricular chamber enlargement and systolic dysfunction with normal left ventricular wall thickness, which leads to progressive HF. Over 60 g...
13 CitationsSource
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