Dan J. Stein
University of Cape Town
Publications 1963
#1Monray E. Williams (UCT: University of Cape Town)
#2Simo S. Zulu (UCT: University of Cape Town)
Last.Petrus J. W. Naudé (UCT: University of Cape Town)H-Index: 2
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Abstract HIV-associated neurocognitive impairments (HANI) are a spectrum of neurological disorders due to the effects of HIV-1 on the central nervous system (CNS). The HIV-1 subtypes; HIV-1 subtype B (HIV-1B) and HIV-1 subtype C (HIV-1C) are responsible for the highest prevalence of HANI and HIV infections respectively. The HIV transactivator of transcription (Tat) protein is a major contributor to the neuropathogenesis of HIV. The effects of the Tat protein on cells of the CNS is determined by ...
Objective: Findings from animal studies indicate that the early gut bacteriome is a potential mechanism linking maternal prenatal stress with health trajectories in offspring. However, clinical studies are scarce and the associations of maternal psychological profiles with the early infant faecal bacteriome are unknown. This study aimed to investigate the associations of prenatal stressors and distress with early infant faecal bacterial profiles in a South African birth cohort study. Methods: As...
#1Suleyman Gulsuner (UW: University of Washington)H-Index: 15
#2Dan J. Stein (UCT: University of Cape Town)H-Index: 109
Last.Odwa A. Ntola (UCT: University of Cape Town)H-Index: 2
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Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical...
#1Dan J. Stein (UCT: University of Cape Town)H-Index: 109
#2Peter Szatmari (U of T: University of Toronto)H-Index: 87
Last.Andreas Maercker (UZH: University of Zurich)H-Index: 50
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An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases and Related Health Problems (ICD) is of great interest around the world. The recent approval of the 11th Revision of the ICD (ICD-11) by the World Health Organization (WHO) raises broad questions about the status of nosology of mental disorders as a whole as well as more focused questions regarding changes to the diagnostic guidelines for specific conditions and the imp...
#1Henk Temmingh (UCT: University of Cape Town)H-Index: 9
#2W. van den Brink (UvA: University of Amsterdam)H-Index: 73
Last.Dan J. Stein (Stellenbosch University)H-Index: 109
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AbstractObjective: Extrapyramidal side-effects (EPSE) are frequent in patients treated with antipsychotics and comorbid substance use disorders (SUDs). Methamphetamine has been shown to act as a do...
#1Annerine Roos (UCT: University of Cape Town)H-Index: 14
#2Jean-Paul Fouche (UCT: University of Cape Town)H-Index: 18
Last.Kirsten A. Donald (UCT: University of Cape Town)H-Index: 15
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#1Anke Hüls (UBC: University of British Columbia)H-Index: 2
#2Aneesa Vanker (UCT: University of Cape Town)H-Index: 6
Last.Heather J. Zar (UCT: University of Cape Town)H-Index: 46
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Introduction Indoor air pollution and maternal smoking during pregnancy are associated with respiratory symptoms in infants, but little is known about the direct association with lung function or interactions with genetic risk factors. We examined associations of indoor particulate matter of diameter ≤10 µm (PM10) exposure and maternal smoking with infant lung function and the role of gene-environment interactions. Methods Data from the Drakenstein Child Health Study, a South African birth cohor...