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Nicola Wilson
Imperial College London
ImmunologyAsthmaExhaled nitric oxideAnesthesiaMedicine
55Publications
33H-index
4,308Citations
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Publications 56
Newest
#2Nicola WilsonH-Index: 33
Last. Helen Dunn (GOSH: Great Ormond Street Hospital)H-Index: 3
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Background Non-sterile gloves are required to protect healthcare workers against blood and bodily fluids (Loveday et al, 2014). Gloves that are worn to protect the patient should be sterile as non-sterile gloves have been shown to be contaminated with a range of bacteria (Berthelot et al, 2006). The RCN Standards for Infusion Therapy (2016) advised that non-sterile gloves should not be routinely worn for the preparation and administration of intravenous medication. The aim of this improvement pr...
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Situation A five week old infant admitted to a tertiary paediatric hospital with coryzal symptoms on a background of Edwards Syndrome (Trisomy 18) and congenital cardiac disease. Despite her grave prognosis, she was intubated and ventilated. She spent many months in hospital, eventually having surgical repair of her cardiac defect which had little or no effect on her clinical condition. She was discharged to a children’s hospice after seven months in our hospital (with short periods at home and ...
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To the Editor: Measurement of fraction of exhaled nitric oxide (FeNO) is an established tool for the assessment of airway inflammation in asthma. Despite increasing evidence of a poor relationship between the two (1), FeNO continues to be widely regarded as a surrogate marker of sputum eosinophilia (2–4). Furthermore, recent American Thoracic Society (ATS) guidelines have suggested clinically significant cut points for low and high FeNO levels that can be used to indicate the presence or absence...
19 CitationsSource
#2Lemonia TsartsaliH-Index: 6
Last. Ashley I. BushH-Index: 131
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Background Two distinct, stable inflammatory phenotypes have been described in adults with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these phenotypes have been successful. This study evaluated sputum cytology in children with asthma to classify sputum inflammatory phenotypes and to assess their stability over time. Methods Sputum induction was performed in 51 children with severe asthma and 28 with mild to moderate asthma. Samples were classified as eosinophilic (>...
107 CitationsSource
#2Nicola WilsonH-Index: 33
Last. Ashley I. BushH-Index: 131
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We thank Professors Pavord and Gibson for their commentary on our study investigating sputum eosinophil counts as a guide to management in children with severe asthma.1 ,2 They suggest two important reasons for our negative results: (1) the protocol was not followed and (2) the protocol was incorrect. For the most part (95% of study visits), the protocol was followed …
79 CitationsSource
#1Ashley I. BushH-Index: 131
#2Cara BossleyH-Index: 12
Last. Nicola WilsonH-Index: 33
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Failure to get the basics right is common at all levels of asthma care. This is highlighted by three recent papers. In a therapeutic study a comparison of azithromycin and montelukast as add on therapies in children with apparently poorly controlled asthma despite being prescribed 400 mcg/day budesonide and long acting b-2 agonists was rendered futile because most of the nearly 300 patients screened either were non-compliant with therapy or turned out to have only mild or no asthma. Two other st...
1 CitationsSource
#1C BossleyH-Index: 5
#2Sejal SaglaniH-Index: 35
Last. Ashley I. BushH-Index: 131
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This study describes the clinical characteristics and corticosteroid responsiveness of children with difficult asthma (DA). We hypothesised that complete corticosteroid responsiveness (defined as improved symptoms, normal spirometry, normal exhaled nitric oxide fraction ( F eNO ) and no bronchodilator responsiveness (BDR We report on 102 children, mean±sd age 11.6±2.8 yrs, with DA in a cross-sectional study. 89 children underwent spirometry, BDR and F eNO before and after 2 weeks of systemic cor...
79 CitationsSource
#1M BrackenH-Index: 1
#2Louise Fleming Mrcpch (NIH: National Institutes of Health)H-Index: 21
Last. Ashley I. BushH-Index: 131
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Objective: To evaluate and identify potentially modifiable factors in children with problematic asthma by a nurse-led assessment and home visit. Design: Observational cohort study. Setting: A tertiary paediatric respiratory centre. Patients: 71 children, aged 4.5–17.5 years, with problematic asthma currently under follow-up at a tertiary respiratory centre. Interventions: A nurse-led hospital visit followed by a home visit. Main outcome measures: Identification and attempted change of exacerbati...
138 CitationsSource
#1Ashley I. BushH-Index: 131
#2Cara BossleyH-Index: 12
Last. Nicola WilsonH-Index: 33
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Abstract Exciting new data are increasing the evidence base for the management of paediatric asthma. To inform the treatment of preschool wheeze, the best current classification is into episodic (viral) and multitrigger wheeze, rather than according to epidemiological pattern (transient versus persistent) and the presence or absence of atopy. Episodic (viral) wheeze is treated intermittently, with either inhaled bronchodilators or oral montelukast at the time of viral colds. If this approach fai...
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Apr 1, 2009 in ATS (American Thoracic Society International Conference)
#1A Gupta (Freeman Hospital)H-Index: 9
#2F BazariH-Index: 1
Last. Ashley I. Bush (NIH: National Institutes of Health)H-Index: 131
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3 CitationsSource
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