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F. Thomas Wunderlich
Max Planck Society
32Publications
19H-index
1,950Citations
Publications 32
Newest
Published on May 1, 2019in Immunity21.52
Lisa Schmidleithner3
Estimated H-index: 3
(University of Bonn),
Yasser Thabet3
Estimated H-index: 3
(University of Bonn)
+ 37 AuthorsFrancesca Copperi (University of Bonn)
Summary Regulatory T cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which catabolizes prostaglandin E 2 (PGE 2 ) into the metabolite 15-keto PGE 2 , was highly expressed in Treg cells, particularly those in visceral adipose tissue (VAT). Nuclear receptor peroxisome prolife...
Published on Nov 1, 2018in Molecular metabolism6.18
Melanie Mittenbühler1
Estimated H-index: 1
(MPG: Max Planck Society),
Hans-Georg Sprenger1
Estimated H-index: 1
(MPG: Max Planck Society)
+ 4 AuthorsF. Thomas Wunderlich19
Estimated H-index: 19
(MPG: Max Planck Society)
Abstract Objective The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase the incidence of hepatocellular carcinoma (HCC), a highly prevalent cancer with poor prognosis. Thus, worldwide incidences of HCC are expected to further increase, and defining the molecular as well as cellular mechanisms will allow for estab...
Published on Dec 1, 2017in Nature Communications11.88
Gero Knittel5
Estimated H-index: 5
(University of Cologne),
Tim Rehkämper2
Estimated H-index: 2
(University of Cologne)
+ 24 AuthorsOleg Fedorchenko4
Estimated H-index: 4
(University of Cologne)
Chronic lymphocytic leukemia (CLL) remains an incurable disease. Two recurrent cytogenetic aberrations, namely del(17p), affecting TP53, and del(11q), affecting ATM, are associated with resistance against genotoxic chemotherapy (del17p) and poor outcome (del11q and del17p). Both del(17p) and del(11q) are also associated with inferior outcome to the novel targeted agents, such as the BTK inhibitor ibrutinib. Thus, even in the era of targeted therapies, CLL with alterations in the ATM/p53 pathway ...
Published on Aug 1, 2017in Hepatology14.97
Christian von Loeffelholz12
Estimated H-index: 12
(Schiller International University),
Stefanie Lieske6
Estimated H-index: 6
(TUD: Dresden University of Technology)
+ 22 AuthorsAntonios Chatzigeorgiou15
Estimated H-index: 15
(TUD: Dresden University of Technology)
Reduced expression of the Indy (‘I am Not Dead, Yet') gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane associated citrate transporter expressed highly in the liver, protects mice from high-fat diet and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We aimed to study a possible role of mIndy in human hepatic fat metabo...
Published on Jun 1, 2017in Kidney International8.31
Sybille Koehler4
Estimated H-index: 4
(University of Cologne),
Sebastian Brähler6
Estimated H-index: 6
(University of Cologne)
+ 8 AuthorsThomas Benzing45
Estimated H-index: 45
(University of Cologne)
Podocyte injury is a key event in glomerular disease leading to proteinuria and opening the path toward glomerular scarring. As a consequence, glomerular research strives to discover molecular mechanisms and signaling pathways affecting podocyte health. The hNphs2.Cre mouse model has been a valuable tool to manipulate podocyte-specific genes and to label podocytes for lineage tracing and purification. Here we designed a novel podocyte-specific tricistronic Cre mouse model combining codon improve...
Published on Jan 1, 2017in Journal of Immunology4.72
Christoph Drees4
Estimated H-index: 4
(TUM: Technische Universität München),
J. Christoph Vahl6
Estimated H-index: 6
(MPG: Max Planck Society)
+ 5 AuthorsMarc Schmidt-Supprian40
Estimated H-index: 40
(TUM: Technische Universität München)
NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage commitment and maturation. During their development, NKT cells are polarized into the NKT1, NKT2, and NKT17 subsets, defined through their cytokine-secretion patterns and the expression of key transcription factors. How...
Published on Jan 1, 2017in Hepatology14.97
Juri Bergmann3
Estimated H-index: 3
,
Miryam Müller5
Estimated H-index: 5
+ 15 AuthorsSusanne Boretius1
Estimated H-index: 1
Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide with rising incidence. The inflammatory cytokine interleukin 6 (IL-6) is a critical mediator of HCC development. It can signal through two distinct pathways, the IL-6 classic and the IL-6 trans-signaling pathway. While IL-6 classic signaling is important for innate and acquired immunity, IL-6 trans-signaling has been linked to accelerated liver regeneration and several chronic inflammatory pathologies. However, its impli...
Published on Mar 21, 2016in PLOS ONE2.78
Sabrina Klebow4
Estimated H-index: 4
(University of Mainz),
Matthias Hahn6
Estimated H-index: 6
(University of Mainz)
+ 4 AuthorsAri Waisman44
Estimated H-index: 44
(University of Mainz)
Psoriasis is an autoimmune skin disease that is associated with aberrant activity of immune cells and keratinocytes. In mice, topical application of TLR7/8 agonist IMQ leads to a skin disorder resembling human psoriasis. Recently, it was shown that the IL-23/ IL-17 axis plays a deciding role in the pathogenesis of human psoriasis, as well as in the mouse model of IMQ-induced psoriasis-like skin disease. A consequence of IL-17A production in the skin includes increased expression and production o...
Published on Dec 1, 2015in BMC Cancer2.93
Raphael H. Rastetter5
Estimated H-index: 5
(Monash University, Clayton campus),
Margit Blömacher2
Estimated H-index: 2
(University of Cologne)
+ 11 AuthorsF. Thomas Wunderlich19
Estimated H-index: 19
(MPG: Max Planck Society)
Background Coronin proteins are known as regulators of actin-based cellular processes, and some of them are associated with the malignant progression of human cancer. Here, we show that expression of coronin 2A is up-regulated in human colon carcinoma.
Published on May 1, 2015in Cell Metabolism22.41
Olivier R. Baris14
Estimated H-index: 14
,
Stefan Ederer1
Estimated H-index: 1
+ 12 AuthorsWolfram S. Kunz50
Estimated H-index: 50
Aging is a progressive decline of body function, during which many tissues accumulate few cells with high levels of deleted mitochondrial DNA (mtDNA), leading to a defect of mitochondrial functions. Whether this mosaic mitochondrial deficiency contributes to organ dysfunction is unknown. To investigate this, we generated mice with an accelerated accumulation of mtDNA deletions in the myocardium, by expressing a dominant-negative mutant mitochondrial helicase. These animals accumulated few random...
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