F. Thomas Wunderlich
Max Planck Society
EndocrinologyImmunologyInsulin resistanceSignal transductionBiology
What is this?
Publications 31
#1Lisa Schmidleithner (University of Bonn)H-Index: 4
#2Yasser Thabet (University of Bonn)H-Index: 4
Last. Marc Beyer (University of Bonn)H-Index: 26
view all 40 authors...
Summary Regulatory T cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which catabolizes prostaglandin E2 (PGE2) into the metabolite 15-keto PGE2, was highly expressed in Treg cells, particularly those in visceral adipose tissue (VAT). Nuclear receptor peroxisome proliferator...
5 CitationsSource
#1Melanie J. Mittenbühler (MPG: Max Planck Society)H-Index: 2
#2Hans-Georg Sprenger (MPG: Max Planck Society)H-Index: 1
Last. F. Thomas Wunderlich (MPG: Max Planck Society)H-Index: 19
view all 7 authors...
Abstract Objective The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase the incidence of hepatocellular carcinoma (HCC), a highly prevalent cancer with poor prognosis. Thus, worldwide incidences of HCC are expected to further increase, and defining the molecular as well as cellular mechanisms will allow for estab...
3 CitationsSource
#1Gero Knittel (University of Cologne)H-Index: 5
#2Tim Rehkämper (University of Cologne)H-Index: 2
Last. H. Christian ReinhardtH-Index: 20
view all 27 authors...
Chronic lymphocytic leukemia (CLL) remains an incurable disease. Two recurrent cytogenetic aberrations, namely del(17p), affecting TP53, and del(11q), affecting ATM, are associated with resistance against genotoxic chemotherapy (del17p) and poor outcome (del11q and del17p). Both del(17p) and del(11q) are also associated with inferior outcome to the novel targeted agents, such as the BTK inhibitor ibrutinib. Thus, even in the era of targeted therapies, CLL with alterations in the ATM/p53 pathway ...
9 CitationsSource
#1Sybille Koehler (University of Cologne)H-Index: 4
#2Sebastian Brähler (University of Cologne)H-Index: 7
Last. Paul T. Brinkkoetter (University of Cologne)H-Index: 26
view all 11 authors...
Podocyte injury is a key event in glomerular disease leading to proteinuria and opening the path toward glomerular scarring. As a consequence, glomerular research strives to discover molecular mechanisms and signaling pathways affecting podocyte health. The hNphs2.Cre mouse model has been a valuable tool to manipulate podocyte-specific genes and to label podocytes for lineage tracing and purification. Here we designed a novel podocyte-specific tricistronic Cre mouse model combining codon improve...
2 CitationsSource
#1Christoph Drees (TUM: Technische Universität München)H-Index: 4
#2J. Christoph Vahl (MPG: Max Planck Society)H-Index: 6
Last. Marc Schmidt-Supprian (TUM: Technische Universität München)H-Index: 43
view all 8 authors...
NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage commitment and maturation. During their development, NKT cells are polarized into the NKT1, NKT2, and NKT17 subsets, defined through their cytokine-secretion patterns and the expression of key transcription factors. How...
4 CitationsSource
#1Juri BergmannH-Index: 3
#2Miryam MüllerH-Index: 6
Last. Dirk Schmidt-ArrasH-Index: 15
view all 18 authors...
Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide with rising incidence. The inflammatory cytokine interleukin 6 (IL-6) is a critical mediator of HCC development. It can signal through two distinct pathways, the IL-6 classic and the IL-6 trans-signaling pathway. While IL-6 classic signaling is important for innate and acquired immunity, IL-6 trans-signaling has been linked to accelerated liver regeneration and several chronic inflammatory pathologies. However, its impli...
34 CitationsSource
#1Christian von Loeffelholz (Schiller International University)H-Index: 13
#2Stefanie Lieske (TUD: Dresden University of Technology)H-Index: 7
Last. Andreas L. BirkenfeldH-Index: 15
view all 25 authors...
Reduced expression of the Indy (‘I am Not Dead, Yet') gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane associated citrate transporter expressed highly in the liver, protects mice from high-fat diet and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We aimed to study a possible role of mIndy in human hepatic fat metabo...
15 CitationsSource
#1Sybille KoehlerH-Index: 4
#2Sebastian BrählerH-Index: 7
Last. Paul T. BrinkkoetterH-Index: 26
view all 14 authors...
Single and Transient Ca 2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion
5 CitationsSource
#1Sabrina Klebow (University of Mainz)H-Index: 6
#2Matthias Hahn (University of Mainz)H-Index: 7
Last. Ari Waisman (University of Mainz)H-Index: 58
view all 7 authors...
Psoriasis is an autoimmune skin disease that is associated with aberrant activity of immune cells and keratinocytes. In mice, topical application of TLR7/8 agonist IMQ leads to a skin disorder resembling human psoriasis. Recently, it was shown that the IL-23/ IL-17 axis plays a deciding role in the pathogenesis of human psoriasis, as well as in the mouse model of IMQ-induced psoriasis-like skin disease. A consequence of IL-17A production in the skin includes increased expression and production o...
2 CitationsSource
#1Raphael H. Rastetter (Monash University, Clayton campus)H-Index: 5
#2Margit Blomacher (University of Cologne)H-Index: 2
Last. Christoph S. Clemen (University of Cologne)H-Index: 22
view all 14 authors...
Background Coronin proteins are known as regulators of actin-based cellular processes, and some of them are associated with the malignant progression of human cancer. Here, we show that expression of coronin 2A is up-regulated in human colon carcinoma.
3 CitationsSource