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Bart O. Roep
City of Hope National Medical Center
276Publications
58H-index
10.9kCitations
Publications 276
Newest
Published on Jul 1, 2019in Diabetes 7.20
Simi Ahmed3
Estimated H-index: 3
(JDRF),
Karen Cerosaletti23
Estimated H-index: 23
(BRI: Benaroya Research Institute)
+ 8 AuthorsKevan C. Herold65
Estimated H-index: 65
(Yale University)
Type 1 diabetes (T1D) results from the progressive destruction of pancreatic β-cells in a process mediated primarily by T lymphocytes. The T1D research community has made dramatic progress in understanding the genetic basis of the disease as well as in the development of standardized autoantibody assays that inform both disease risk and progression. Despite these advances, there remains a paucity of robust and accepted biomarkers that can effectively inform on the activity of T cells during the ...
Published on May 1, 2019in International Journal of Pharmaceutics 4.21
M. Dul (Cardiff University), Tatjana Nikolic11
Estimated H-index: 11
(LUMC: Leiden University Medical Center)
+ 12 AuthorsMark Peakman52
Estimated H-index: 52
Antigen specific immunotherapy aims to tolerise patients to specific autoantigens that are responsible for the pathology of an autoimmune disease. Immune tolerance is generated in conditions where the immune response is suppressed and thus gold nanoparticles (AuNPs) are an attractive drug delivery platform due to their anti-inflammatory effects and their potential to facilitate temporal and spatial delivery of a peptide autoantigen in conjunction with pro-tolerogenic elements. In this study we h...
Published on Apr 1, 2019in Diabetes 7.20
Menno van Lummel8
Estimated H-index: 8
(LUMC: Leiden University Medical Center),
David T.P. Buis (LUMC: Leiden University Medical Center)+ 7 AuthorsBart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center)
The heterozygous DQ2/8 (DQA1*05:01-DQB1*02:01/DQA1*03:01-DQB1*03:02) genotype confers the highest risk in type 1 diabetes (T1D), whereas the DQ6/8 (DQA1*02:01-DQB1*06:02/DQA1*03:01-DQB1*03:02) genotype is protective. The mechanism of dominant protection by DQ6 (DQB1*06:02) is unknown. We tested the hypothesis that DQ6 interferes with peptide binding to DQ8 by competition for islet epitope (“epitope stealing”) by analysis of the islet ligandome presented by HLA-DQ6/8 and -DQ8/8 on dendritic cells...
Published on Mar 1, 2019in The Journal of Steroid Biochemistry and Molecular Biology 3.79
An-Sofie Vanherwegen5
Estimated H-index: 5
(Katholieke Universiteit Leuven),
Guy Eelen24
Estimated H-index: 24
(Katholieke Universiteit Leuven)
+ 8 AuthorsChantal Mathieu78
Estimated H-index: 78
(Katholieke Universiteit Leuven)
Abstract Tolerogenic dendritic cells (tolDCs) instruct regulatory T cells (Tregs) to dampen autoimmunity. Active vitamin D 3 (1α,25-dihydroxyvitamin D 3 ; 1α,25(OH) 2 D 3 ) imprints human monocyte-derived DCs with tolerogenic properties by reprogramming their glucose metabolism. Here we identify the glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) as a critical checkpoint and direct transcriptional target of 1α,25(OH) 2 D 3 in determining the tolDC profile. Using ...
Published on Mar 1, 2019in Nature 43.07
Kenichiro Furuyama2
Estimated H-index: 2
(University of Geneva),
Simona Chera19
Estimated H-index: 19
(University of Bergen)
+ 14 AuthorsThierry Berney51
Estimated H-index: 51
(University of Geneva)
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells and somatostatin-producing δ-cells become insulin-expressing cells after the ablation of insulin-secreting β-cells, thus promoting diabetes recovery. Whether human islets also display this plasticity, especially in diabetic cond...
Published on Jan 1, 2019in The Lancet Diabetes & Endocrinology 24.54
Mark A. Atkinson82
Estimated H-index: 82
(UF: University of Florida),
Bart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center)
+ 2 AuthorsMark Peakman52
Estimated H-index: 52
(HealthPartners)
Summary With the conceptual advance about four decades ago that type 1 diabetes represents an autoimmune disease, hope arose that immune-based therapies would soon emerge to prevent and reverse the disorder. However, despite dozens of clinical trials seeking to achieve these goals, the promise remains unfulfilled, at least in a pragmatic form. With the benefit of hindsight, several important reasons are likely to account for this disappointing outcome, including failure to appreciate disease het...
Published on Jan 1, 2019in The Lancet Diabetes & Endocrinology 24.54
Bart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center),
Daniel C S Wheeler1
Estimated H-index: 1
('KCL': King's College London),
Mark Peakman52
Estimated H-index: 52
(HealthPartners)
Summary Precision medicine has emerged as a mantra for therapeutic approaches to complex diseases. The defining concept relies on a detailed insight into disease pathogenesis and therapeutic mechanism. Although the type 1 diabetes field has gained new insights into disease endotypes and indications of efficacy for several therapies, none of these is yet licensed, partly because of immune suppressive side-effects beyond control of islet autoimmunity. New strategies designed to regulate the immune...
Published on Dec 1, 2018in Scientific Reports 4.01
Maria Jl Kracht3
Estimated H-index: 3
(LUMC: Leiden University Medical Center),
Eelco J.P. de Koning34
Estimated H-index: 34
(LUMC: Leiden University Medical Center)
+ 2 AuthorsArnaud Zaldumbide16
Estimated H-index: 16
(LUMC: Leiden University Medical Center)
During type 1 diabetes development, cells in the islets of Langerhans engage adaptive mechanisms in response to inflammatory signals to cope with stress, to restore cellular homeostasis, and to preserve cell function. Disruption of these mechanisms may induce the formation of a repertoire of stress-induced neoantigens, which are critical in the loss of tolerance to beta cells and the development of autoimmunity. While multiple lines of evidence argue for a critical role of the endoplasmic reticu...
Published on Dec 1, 2018in Diabetes 7.20
Eunjin Oh15
Estimated H-index: 15
(City of Hope National Medical Center),
Miwon Ahn1
Estimated H-index: 1
(City of Hope National Medical Center)
+ 3 AuthorsDebbie C. Thurmond2
Estimated H-index: 2
(City of Hope National Medical Center)
Syntaxin 4 (Stx4) enrichment in human and mouse islet grafts improves the success of transplants in reversing streptozotocin (STZ)-induced diabetes in mice, although the underlying molecular mechanisms remain elusive. Toward a further understanding of this, human islets and inducible transgenic mice that selectively overexpress Stx4 in islet β-cells (βTG-Stx4) were challenged with proinflammatory stressors in vitro and in vivo. Remarkably, βTG-Stx4 mice resisted the loss of β-cell mass and the g...
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