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Stephan J. L. Bakker
University Medical Center Groningen
EndocrinologyRenal functionPopulationDiabetes mellitusMedicine
873Publications
70H-index
24.6kCitations
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Publications 903
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#1Adrian Post (UMCG: University Medical Center Groningen)H-Index: 3
#2Robin P. F. Dullaart (UMCG: University Medical Center Groningen)H-Index: 47
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 70
view all 3 authors...
: The angiotensin-converting enzyme 2 receptor (ACE2) is expressed in epithelial cells of many tissues including the kidney, and has been identified to interact with human pathogenic coronaviruses, including SARS-CoV-2. Although diffuse alveolar damage and acute respiratory failure are the main features of COVID-19 infection, two recent studies demonstrate that kidney impairment in hospitalized COVID-19 patients is common, and that kidney involvement is associated with high risk of in-hospital d...
2 CitationsSource
#1J Casper SwarteH-Index: 1
#2Coby EelderinkH-Index: 6
Last. Hermie J. M. HarmsenH-Index: 55
view all 9 authors...
The influence of dairy on the gut microbiome has not been studied extensively. We performed a randomized cross-over study to analyze the effect of high dairy intake on the gut microbiome. Subjects were randomly assigned to a high-dairy diet (HDD) (5–6 dairy portions per day) and a low-dairy diet (LDD) (≤1 dairy portion per day) for 6 weeks with a washout period of 4 weeks in between both diets. The gut microbiome was assessed using 16S rRNA gene sequencing. Compositionality and functionality of ...
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#1Carolien P.J. Deen (UMCG: University Medical Center Groningen)H-Index: 1
#2Anna van der Veen (UMCG: University Medical Center Groningen)H-Index: 2
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 70
view all 8 authors...
It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N1-methylnicotinamide (N1-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with premature mortality in kidney transplant recipients (KTR). However, recent evidence implies higher enzymatic conversion of N1-MN to N1-methyl-2-pyridone-5-carboxamide (2Py) in KTR, therefore the need exists for interpreta...
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#1Dion Groothof (UMCG: University Medical Center Groningen)H-Index: 2
#2Jose L. Flores-Guerrero (UMCG: University Medical Center Groningen)H-Index: 3
Last. Jens H. J. Bos (UG: University of Groningen)H-Index: 10
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PURPOSE Although thyroid hormones are irrefutably implicated in cardiovascular physiology, the impact of within-reference range variations of thyroid function on cardiovascular disease (CVD) remains unclear. Elucidating this is important, since it could foster preventive treatment and reduce global CVD burden. We therefore investigated the impact of within-reference range variations of thyroid function on all-cause and cardiovascular mortality. METHODS We included community-dwelling individuals ...
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#1Turtushikh Damba (Mongolian National University)
#1Turtushikh Damba (UMCG: University Medical Center Groningen)H-Index: 1
Last. Robin P. F. Dullaart (UMCG: University Medical Center Groningen)H-Index: 47
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BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, inflammation and an imbalanced redox homeostasis. We hypothesized that systemic free thiol levels, as a proxy of systemic oxidative stress, are associated with NAFLD. METHODS Protein-adjusted serum free thiol concentrations were determined in participants from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study (n=5,562). Suspected NAFLD was defined by the Fatty...
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#1Camilo G. Sotomayor (UMCG: University Medical Center Groningen)H-Index: 4
#2Charlotte A. te Velde-Keyzer (UMCG: University Medical Center Groningen)H-Index: 1
Last. Martin H. de Borst (UMCG: University Medical Center Groningen)H-Index: 27
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BACKGROUND Galectin-3 may play a causal role in kidney inflammation and fibrosis, which may also be involved in the development of kidney graft failure. With novel galectin-3 targeted pharmacological therapies increasingly coming available, we aimed to investigate whether galectin-3 is associated with risk of late graft failure in kidney transplant recipients (KTR). METHODS We studied adult KTR who participated in TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study, recr...
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#1Hanneke J C M Wouters (UMCG: University Medical Center Groningen)H-Index: 4
#2Suzanne P. Stam (UMCG: University Medical Center Groningen)H-Index: 3
Last. Michele F. Eisenga (UMCG: University Medical Center Groningen)H-Index: 9
view all 5 authors...
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#1Camilo G. Sotomayor (UMCG: University Medical Center Groningen)H-Index: 4
#2Charlotte A. te Velde-Keyzer (UMCG: University Medical Center Groningen)H-Index: 1
Last. Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 70
view all 5 authors...
After decades of pioneering and improvement, kidney transplantation is now the renal replacement therapy of choice for most patients with end-stage kidney disease (ESKD). Where focus has traditionally been on surgical techniques and immunosuppressive treatment with prevention of rejection and infection in relation to short-term outcomes, nowadays, so many people are long-living with a transplanted kidney that lifestyle, including diet and exposure to toxic contaminants, also becomes of importanc...
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#1Rianne M. Douwes (UMCG: University Medical Center Groningen)H-Index: 4
#2António W Gomes-Neto (UMCG: University Medical Center Groningen)H-Index: 5
Last. Stefan P. Berger (UMCG: University Medical Center Groningen)H-Index: 30
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Background Chronic use of proton-pump inhibitors (PPIs) is common in kidney transplant recipients (KTRs). However, concerns are emerging about the potential long-term complications of PPI therapy. We aimed to investigate whether PPI use is associated with excess mortality risk in KTRs. Methods and findings We investigated the association of PPI use with mortality risk using multivariable Cox proportional hazard regression analyses in a single-center prospective cohort of 703 stable outpatient KT...
1 CitationsSource
#1Adrian Post (UMCG: University Medical Center Groningen)H-Index: 3
#2Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 70
Last. Robin P. F. Dullaart (UMCG: University Medical Center Groningen)H-Index: 47
view all 3 authors...
The SARS-CoV-2 pandemic has led to worldwide research aiming to identify the risk factors for developing critical illness and mortality caused by COVID-19. It quickly became apparent that besides older age, obesity is one of the most important risk factors for a more severe course of COVID-19, although the mechanisms remain largely unknown [1-3]. Notably, with respect to acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), evidence is mounting that obesity is a risk factor for...
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