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D. Gareth Evans
St Mary's Hospital
723Publications
99H-index
40.9kCitations
Publications 723
Newest
#1Mev Dominguez-Valentin (Oslo University Hospital)H-Index: 3
#2Toni Seppälä (UH: University of Helsinki)H-Index: 5
Last.Pål Møller (Oslo University Hospital)H-Index: 47
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Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated.
#1Toni Seppälä (UH: University of Helsinki)H-Index: 5
#2Aysel Ahadova (Heidelberg University)
Last.Pål Møller (Oslo University Hospital)H-Index: 47
view all 57 authors...
Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres. This observation conflicts with the paradigm that removal of all visible polyps should prevent the vast majority of CRC in path_MMR carriers, provided the screening interval is sufficiently short and colonoscopic practice is optimal.
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Sara Lindstroem (UW: University of Washington)H-Index: 43
view all 333 authors...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Sara Lindstroem (UW: University of Washington)H-Index: 43
view all 333 authors...
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
Women at increased breast cancer (BC) risk are eligible for chemoprevention. Healthy lifestyles are potentially important for these women to improve efficacy and minimise side effects of chemoprevention and reduce the risk of BC and other lifestyle-related conditions. We investigated whether women t
#1Li Sun (Lond: University of London)H-Index: 1
#2Adam R. Brentnall (QMUL: Queen Mary University of London)H-Index: 16
Last.Ranjit ManchandaH-Index: 14
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Importance Moving to multigene testing for all women with breast cancer (BC) could identify many more mutation carriers who can benefit from precision prevention. However, the cost-effectiveness of this approach remains unaddressed. Objective To estimate incremental lifetime effects, costs, and cost-effectiveness of multigene testing of all patients with BC compared with the current practice of genetic testing (BRCA) based on family history (FH) or clinical criteria. Design, Setting, and Partici...
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