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Ming-tai Wang
Zhengzhou University
4Publications
4H-index
91Citations
Publications 4
Newest
#1Qinghe Xing (CAS: Chinese Academy of Sciences)H-Index: 27
#2Ming-tai Wang (Zhengzhou University)H-Index: 4
Last.Lin He (CAS: Chinese Academy of Sciences)H-Index: 57
view all 10 authors...
Dyschromatosis symmetrica hereditaria (DSH [MIM 127400]) is characterized by the presence of hyperpigmented and hypopigmented macules mostly on the dorsal aspects of the extremities. Genetic studies have identified mutations in the ADAR gene, encoding double-stranded RNA-specific adenosine deaminase, to be responsible for this disorder. Here, we found a novel deletion mutation in the ADAR gene, 2929delA, in a Chinese family with DSH. This mutation is located in codon 977 (AGC→GC), and leads to a...
15 CitationsSource
#1Qinghe Xing (CAS: Chinese Academy of Sciences)H-Index: 27
#2Xiangdong ChenH-Index: 3
Last.Lin He (CAS: Chinese Academy of Sciences)H-Index: 57
view all 12 authors...
Generalized lentiginosis (GL) is characterized by widespread lentigines without associated noncutaneous abnormalities. In this study we performed a genome-wide linkage search in a Chinese family with GL and localized the familial GL locus to chromosome 4q21.1–q22.3, with a maximum two-point LOD score of 3.01 for D4S395 and D4S423 at a recombination fraction of 0. Multipoint analysis (maximum LOD score of 5.08 between markers D4S395 and D4S1563) and haplotype construction showed strong evidence o...
4 CitationsSource
#1Qinghe Xing (CAS: Chinese Academy of Sciences)H-Index: 27
#2Shengnan Wu (CAS: Chinese Academy of Sciences)H-Index: 9
Last.Lin He (CAS: Chinese Academy of Sciences)H-Index: 57
view all 9 authors...
Abstract Several studies have suggested that the transcriptional activity of the DRD4 gene may exert an important role in susceptibility to schizophrenia. To address this issue, we studied the association of schizophrenia and polymorphisms including −616C>G, −603T>del, −602G>del, 600G>C, −521C>T, −376C>T and a 120 bp tandem duplication polymorphism (120 bp repeat) in 1.2 kb upstream from the initiation codon in the promoter region of the DRD4 gene with 210 schizophrenic cases and 206 healthy con...
30 CitationsSource
#1Qinghe Xing (CAS: Chinese Academy of Sciences)H-Index: 27
#2Xiangdong ChenH-Index: 3
Last.Lin He (CAS: Chinese Academy of Sciences)H-Index: 57
view all 11 authors...
Dyschromatosis symmetrica hereditaria (DSH) is a hereditary skin disease characterized by the presence of hyperpigmented and hypopigmented macules on extremities and face. The gene, or even its chromosomal location, for DSH has not yet been identified. In this study, two Chinese families with DSH were identified and subjected to a genomewide screen for linkage analysis. Two-point linkage analysis for pedigree A (maximum LOD score [Zmax] = 7.28 at recombination fraction [θ] = 0.00) and pedigree B...
42 CitationsSource
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