Jenny Chang-Claude
German Cancer Research Center
Publications 903
#1Philip J. Law (ICR: Institute of Cancer Research)H-Index: 10
#2Maria Timofeeva (Medical Research Council)H-Index: 12
Last.Victoria Svinti (Medical Research Council)
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Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Joe Dennis (University of Cambridge)H-Index: 37
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#1Elizabeth Alwers (DKFZ: German Cancer Research Center)H-Index: 3
#2Hendrik Bläker (Charité)H-Index: 28
Last.Wilfried Roth (University Hospital Heidelberg)H-Index: 3
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Background Competing molecular classification systems have been proposed to complement the TNM staging system for a better prediction of survival in colorectal cancer (CRC). However, validation studies are so far lacking. The aim of this study was to validate and extend previously published molecular classifications of CRC in a large independent cohort of CRC patients.
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 5
#2Hilary K. Finucane (Broad Institute)H-Index: 24
Last.Karoline Kuchenbaecker (UCL: University College London)H-Index: 3
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Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
#1Alina Vrieling (Radboud University Nijmegen)H-Index: 33
Last.Marie Christine Boutron-Ruault (University of Paris-Sud)H-Index: 78
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Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 ...
#1Korbinian Weigl (DKFZ: German Cancer Research Center)H-Index: 4
#2Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 89
Last.Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 113
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#1Stefanie Jaskulski (DKFZ: German Cancer Research Center)H-Index: 2
#2Audrey Y. Jung (DKFZ: German Cancer Research Center)H-Index: 4
Last.Heiko Becher (UHH: University of Hamburg)H-Index: 49
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#1Anne J.M.R. Geijsen (WUR: Wageningen University and Research Centre)H-Index: 1
#2Eline H. van Roekel (UM: Maastricht University)H-Index: 5
Last.Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 113
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