Jenny Chang-Claude
German Cancer Research Center
CancerBreast cancerGeneticsMedicineBiology
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Publications 901
#1Jeroen R. Huyghe (Fred Hutchinson Cancer Research Center)H-Index: 16
#2Tabitha A. Harrison (Fred Hutchinson Cancer Research Center)H-Index: 17
Last. Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
view all 141 authors...
Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the cont...
#1Feng Guo (DKFZ: German Cancer Research Center)
#2Korbinian Weigl (DKFZ: German Cancer Research Center)H-Index: 5
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 9 authors...
Abstract Background & Aims Polygenic risk scores (PRSs) could help to define starting ages for colorectal cancer (CRC) screening. However, the role of PRS in determining the length of screening interval after negative findings from colonoscopies is unclear. We aimed to evaluate colorectal cancer (CRC) risk according to PRS and time since last negative colonoscopy. Methods We collected data from 3827 cases and 2641 CRC-free controls in a population-based case-control study in Germany. We construc...
#1Pooja Middha Kapoor (DKFZ: German Cancer Research Center)H-Index: 1
#2Nasim Mavaddat (University of Cambridge)H-Index: 14
Last. Qin Wang (University of Cambridge)H-Index: 37
view all 143 authors...
Combining polygenic risk score (PRS) with classical risk factors could improve accuracy of breast cancer prediction models. We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors in women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overal...
#1Siddhartha Kar (Medical Research Council)
#2Daniel Considine (University of Cambridge)H-Index: 1
Last. Fernando Moreno Antón (Hospital Clínico San Carlos)H-Index: 5
view all 56 authors...
Familial, genome-wide association (GWAS), and sequencing studies and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWAS) to identify candidate breast cancer and ovarian cancer susceptibility genes. We built gene expression prediction models using the PrediXcan method in 681 breast an...
#1Peter T. Campbell (ACS: American Cancer Society)H-Index: 35
#2Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 92
view all 39 authors...
BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg.m2) and approximately 2.7 million single nucleotide polymorphisms (SNPs) with colorectal cancer risk among 14,059 colorectal cancer case (53.2% women) and 14,416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included two-step (i....
#1Daniel Boakye (DKFZ: German Cancer Research Center)H-Index: 1
#1Daniel Boakye (DKFZ: German Cancer Research Center)H-Index: 2
Last. Hermann Brenner (DKFZ: German Cancer Research Center)H-Index: 119
view all 10 authors...
Oxidative stress has been implicated in the initiation of several cancers, including colorectal cancer (CRC). Whether it also plays a role in CRC prognosis is unclear. We assessed the associations of two oxidative stress biomarkers (Diacron's reactive oxygen metabolites [d-ROMs] and total thiol level [TTL]) with CRC prognosis. CRC patients who were diagnosed in 2003-2012 and recruited into a population-based study in Germany (N = 3361) were followed for up to 6 years. Hazard ratios (HRs) and 95%...
#1Daniele Giardiello (LUMC: Leiden University Medical Center)H-Index: 4
#2Michael Hauptmann (NKI-AVL: Netherlands Cancer Institute)H-Index: 44
Last. Mariël BrinkhuisH-Index: 4
view all 57 authors...
BACKGROUND: Three tools are currently available to predict the risk of contralateral breast cancer (CBC). We aimed to compare the performance of the Manchester formula, CBCrisk, and PredictCBC in patients with invasive breast cancer (BC). METHODS: We analyzed data of 132,756 patients (4682 CBC) from 20 international studies with a median follow-up of 8.8 years. Prediction performance included discrimination, quantified as a time-dependent Area-Under-the-Curve (AUC) at 5 and 10 years after diagno...
#1Ruth Elisa Eyl (DKFZ: German Cancer Research Center)
#1Ruth Elisa Eyl (DKFZ: German Cancer Research Center)H-Index: 1
Last. Volker Arndt (DKFZ: German Cancer Research Center)H-Index: 53
view all 9 authors...
Evidence suggests that physical activity(PA) is positively associated with health-related quality of life(QOL) in colorectal cancer(CRC) survivors. However, little is known regarding long-term effects of PA on QOL and if pre-diagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term QOL in CRC survivors. This study is based on a population-based cohort from Germany of 1781 newly diagnosed CRC survi...
#1Anika Hüsing (DKFZ: German Cancer Research Center)H-Index: 17
#2Anne S. Quante (LMU: Ludwig Maximilian University of Munich)H-Index: 6
Last. Ruth M. PfeifferH-Index: 5
view all 6 authors...
PURPOSE: There are no models for German women that predict absolute risk of invasive breast cancer (BC), i.e., the probability of developing BC over a prespecified time period, given a woman's age and characteristics, while accounting for competing risks. We thus validated two absolute BC risk models (BCRAT, BCRmod) developed for US women in German women. BCRAT uses a woman's medical, reproductive, and BC family history; BCRmod adds modifiable risk factors (body mass index, hormone replacement t...
1 CitationsSource
#1Ana Babic (Harvard University)H-Index: 12
#2Naoko Sasamoto (Brigham and Women's Hospital)H-Index: 3
Last. Renée T. Fortner (DKFZ: German Cancer Research Center)H-Index: 16
view all 31 authors...
Importance Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs by histotype is unclear. Furthermore, the observed associations between duration and timing of breastfeeding with ovarian cancer risk have been inconsistent. Objective To determine the association between breastfeeding (ie, ever/never, duration, timing) and ovarian can...