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Prem Prakash
University of Iowa
EndocrinologyThrombosisBiochemistryMedicinePlatelet
35Publications
13H-index
437Citations
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Publications 33
Newest
#1Varun DhimanH-Index: 1
#2Deepak PantH-Index: 10
Last. Prem PrakashH-Index: 13
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#1Ankita MisraH-Index: 7
#2Prem PrakashH-Index: 13
Last. Madhu DikshitH-Index: 36
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#1Mehul R. Chorawala (UI: University of Iowa)H-Index: 5
#2Prem Prakash (UI: University of Iowa)H-Index: 13
Last. Anil K. Chauhan (UI: University of Iowa)H-Index: 28
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Background Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI). Very little is known about the role of Fn-EDA in the pathophysiology of acute MI under these co-morbid conditions. Materials and Methods We ...
2 CitationsSource
#1Mehul R. Chorawala (UI: University of Iowa)H-Index: 5
#2Prem Prakash (UI: University of Iowa)H-Index: 13
Last. Anil K. Chauhan (UI: University of Iowa)H-Index: 28
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#1Prem PrakashH-Index: 13
#2Ahmar AftabH-Index: 1
Last. Satish KumarH-Index: 55
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#1Ankita Misra (CSIR: Council of Scientific and Industrial Research)H-Index: 7
#2Prem Prakash (CSIR: Council of Scientific and Industrial Research)H-Index: 13
Last. Madhu Dikshit (CSIR: Council of Scientific and Industrial Research)H-Index: 36
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Abstract Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown better antithrombotic protection than aspirin and clopidogrel with minimal bleeding tendency in mice. The present study is aimed to systematically investigate the antithrombotic efficacy of S007-867 in comparison to aspirin and clopidogrel in vivo and to delineate...
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#1Prem Prakash (UI: University of Iowa)H-Index: 13
#2Manasa K. Nayak (UI: University of Iowa)H-Index: 10
Last. Anil K. Chauhan (UI: University of Iowa)H-Index: 28
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: Essentials The main receptor for platelet glycoprotein (GP) Ibα is von Willebrand factor (VWF). P-selectin and thrombospondin-1 (TSP1) have been suggested as counter receptors for GPIbα. In a laser injury model, P-selectin promotes thrombus propagation independently of VWF and TSP1. In a laser injury model, thrombus persists in interleukin-4 receptor α/GPIbα-transgenic mice. SUMMARY: Background P-selectin and thrombospondin-1 (TSP1) have been suggested as counter ligands that may mediate GPIbα...
5 CitationsSource
#1Nirav Dhanesha (UI: University of Iowa)H-Index: 14
#2Prem Prakash (UI: University of Iowa)H-Index: 13
Last. Anil K. Chauhan (UI: University of Iowa)H-Index: 28
view all 8 authors...
Objective—von Willebrand factor (VWF), which is synthesized in endothelial cells and megakaryocytes, is known to worsen stroke outcome. In vitro studies suggest that platelet-derived VWF (Plt-VWF) is biochemically different from the endothelial cell–derived VWF (EC-VWF). However, little is known about relative contribution of different pools of VWF in stroke. Approach and Results—Using bone marrow transplantation, we generated chimeric Plt-VWF mice, Plt-VWF mice that lack ADAMTS13 in platelets a...
16 CitationsSource
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