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Andrew Garazha
Moscow Institute of Physics and Technology
41Publications
10H-index
333Citations
Publications 42
Newest
(1) Background: Machine learning (ML) methods are rarely used for an omics-based prescription of cancer drugs, due to shortage of case histories with clinical outcome supplemented by high-throughput molecular data. This causes overtraining and high vulnerability of most ML methods. Recently, we proposed a hybrid global-local approach to ML termed floating window projective separator (FloWPS) that avoids extrapolation in the feature space. Its core property is data trimming, i.e., sample-specific...
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#1Nicolas BorisovH-Index: 8
#2Maxim SorokinH-Index: 9
Last.Anton BuzdinH-Index: 9
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2 CitationsSource
#2Maxim SorokinH-Index: 9
Last.Anton BuzdinH-Index: 9
view all 5 authors...
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#1Victor TkachevH-Index: 5
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 5 authors...
1 CitationsSource
#1Maria SuntsovaH-Index: 9
#2Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 14 authors...
Comprehensive analysis of molecular pathology requires a collection of reference samples representing normal tissues from healthy donors. For the available limited collections of normal tissues from postmortal donors, there is a problem of data incompatibility, as different datasets generated using different experimental platforms often cannot be merged in a single panel. Here, we constructed and deposited the gene expression database of normal human tissues based on uniformly screened original ...
2 CitationsSource
#1Nicolas Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 8
#2Irina Shabalina (PetrSU: Petrozavodsk State University)H-Index: 5
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
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Background Harmonization techniques make different gene expression profiles and their sets compatible and ready for comparisons. Here we present a new bioinformatic tool termed Shambhala for harmonization of multiple human gene expression datasets obtained using different experimental methods and platforms of microarray hybridization and RNA sequencing.
5 CitationsSource
Study Objective To develop a prototype of a complex gene expression biomarker for the diagnosis of endometriosis based on differences between molecular signatures of endometrium from women with and without endometriosis. Design Prospective observational cohort study. II-1. Evidence obtained from a well-designed, controlled trial without randomization. Setting Department of Reproductive Medicine and Surgery at the A.I. Evdokimov Moscow State Medical and Dental University. Patients or Participants...
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#1Daniil NikitinH-Index: 3
#2Andrew GarazhaH-Index: 10
Last.Anton BuzdinH-Index: 26
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In the article ‘Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution,’ a number of transcription factor binding sites (TFBS) mapped on all retroelement classes were incorrectly calculated as sum of TFBS numbers separately mapped on LINEs, SINEs and LTR retrotransposons/endogenous retroviruses (LR/ERVs) [...]
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#1Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Alexey Moiseev (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 1
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Abstract Molecular diagnostics is becoming one of the major drivers of personalized oncology. With hundreds of different approved anticancer drugs and regimens of their administration, selecting the proper treatment for a patient is at least nontrivial task. This is especially sound for the cases of recurrent and metastatic cancers where the standard lines of therapy failed. Recent trials demonstrated that mutation assays have a strong limitation in personalized selection of therapeutics, conseq...
1 CitationsSource
#1Anton BuzdinH-Index: 26
#2Andrew GarazhaH-Index: 10
Last.Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
view all 11 authors...
e13032Background: Intracellular molecular pathways (IMPs) control all major events in the living cell. They are considered hotspots in contemporary oncology because knowledge of IMPs activation is ...
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