Marcus Richards
University College London
Publications 391
Objective To determine whether hypothalamus-pituitary-adrenal axis (HPAA) dysfunction is prospectively associated with global cognitive impairment in later life. Methods This cross-cohort study integrates 2 large longitudinal datasets, Whitehall II and the National Survey for Health and Development (NSHD), on data collected in the Whitehall II study between 2002–2004, 2007–2009, and 2012–2013; and for NSHD between 2006–2010 and in 2015. Serial salivary cortisol samples were collected multiple ti...
#1Kirsty LuH-Index: 2
Last.Jonathan M. SchottH-Index: 49
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Objective To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for associations between cognition and dementia biomarkers in Insight 46, a substudy of the Medical Research Council National Survey of Health and Development. Methods A total of 502 individuals born in the same week in 1946 underwent cognitive assessment at age 69–71 years, including an adapted version of the PACC and a test of nonverbal rea...
#1Sean A. P. Clouston (SBU: Stony Brook University)H-Index: 15
#2Erica D. Diminich (SBU: Stony Brook University)H-Index: 1
Last.Benjamin J. Luft (SBU: Stony Brook University)H-Index: 49
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Abstract Objective This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standa...
1 CitationsSource
#1Michael P. Gardner (University of Oxford)H-Index: 16
Last.Yoav Ben-ShlomoH-Index: 87
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Evidence on the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages is mixed. We undertook a systematic review (until October 2016) and individual participant data (IPD) meta-analysis to test if dysregulation of the HPA axis is associated with worse cognitive capability. Five cohort studies were included in the IPD meta-analysis of diurnal cortisol patterns with crystallised and fluid cognitive ability. Higher night time cortiso...
1 CitationsSource
#1Amber John (University of Sussex)H-Index: 2
#2Sarah-Naomi JamesH-Index: 4
Last.Darya Gaysina (University of Sussex)H-Index: 13
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Abstract Background Little is known about the link between affective symptoms and cognitive function across the life course. This study aims to investigate whether affective symptoms in adolescence and adulthood predict trajectories of cognitive function from middle to late-adulthood. Methods Data from the MRC National Survey of Health and Development (NSHD), a cohort of 5362 individuals born in mainland UK in 1946, were utilised. Linear mixed models were used to model cognitive trajectories (me...
#1Ahmed Elhakeem (UoB: University of Bristol)H-Index: 5
#2Kimberly Hannam (UoB: University of Bristol)H-Index: 7
Last.Jonathan H Tobias (UoB: University of Bristol)H-Index: 39
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Background Little is known about how different physical activity (PA) parameters relate to cognitive function in older adults. Using accelerometers calibrated to detect vertical impacts from ground reaction forces we examined the associations of low, medium and higher impact PA with processing speed, verbal memory and cognitive state in older adults.
Introduction Slowing of gait is associated with risk of cognitive decline, but whether this is due to brain pathology or a consequence of normal neural ageing remains unclear. We investigate associations between gait speed, cognitive test scores, white matter hyperintensity (WMH) volume, whole brain volume (WBV) and β-amyloid load in a sample of healthy older adults born in the same week of March 1946 in mainland Britain. Methods 502 participants underwent quantitative gait measurement, neuropsy...
#1Miharu NakanishiH-Index: 13
#2Syudo YamasakiH-Index: 12
Last.Marcus RichardsH-Index: 51
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