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Véronique Collin-Faure
Centre national de la recherche scientifique
Oxidative stressProteomicsBiochemistryBiologyCell biology
17Publications
10H-index
220Citations
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Publications 19
Newest
Iron oxide nanoparticles/microparticles are widely present in a variety of environments, e.g., as a byproduct of steel and iron degradation, as, for example, in railway brakes (e.g., metro station) or in welding fumes. As all particulate material, these metallic nanoparticles are taken up by macrophages, a cell type playing a key role in the innate immune response, including pathogen removal phagocytosis, secretion of free radical species such as nitric oxide or by controlling inflammation via c...
1 CitationsSource
#2Bastien DalzonH-Index: 2
Last. Thierry RabilloudH-Index: 43
view all 4 authors...
Synthetic amorphous silica is used in various applications such as cosmetics, food, or rubber reinforcement. These broad uses increase human exposure, and thus the potential risk related to their short- and long-term toxicity for both consumers and workers. These potential risks have to be investigated, in a global context of multi-exposure, as encountered in human populations. However, most of the in vitro research on the effects of amorphous silica has been carried out in an acute exposure mod...
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#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Anaëlle Torres (CNRS: Centre national de la recherche scientifique)
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 12 authors...
Silver nanoparticles are known to strongly affect biological systems, and numerous toxicological studies have investigated their effects. Most of these studies examine the effects immediately following acute exposure. In this work, we have conducted further investigation by studying not only the acute, post-exposure response, but also the cellular response after a 72 hour-recovery-phase post exposure. As a biological model we have used macrophages, which are very important cells with respect to ...
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#1Bastien DalzonH-Index: 2
#2Joanna BonsH-Index: 1
Last. Thierry RabilloudH-Index: 43
view all 9 authors...
Metal-containing drugs have long been used in anticancer therapies. The mechansims of action of platinum-based drugs are now well-understood, which cannot be said of drugs containing other metals, such as gold or copper. To gain further insights into such mechanisms, we used a classical proteomic approach based on two-dimensional elelctrophoresis to investigate the mechanisms of action of a hydroxyquinoline-copper complex, which shows promising anticancer activities, using the leukemic cell line...
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#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Mélanie Guidetti (UGA: University of Grenoble)H-Index: 1
Last. Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
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Many solid tumors and their metastases are still resistant to current cancer treatments such as chemo- and radiotherapy. The presence of a small population of Cancer Stem Cells in tumors is held responsible for relapses. Moreover, the various physical barriers of the organism (e.g. blood–brain barrier) prevent many drugs from reaching the target cells. In order to alleviate this constraint, we suggest a Trojan horse strategy consisting of intravascular injection of macrophages loaded with therap...
1 CitationsSource
#1Renaud PrudentH-Index: 14
Last. Thierry RabilloudH-Index: 43
view all 9 authors...
3 CitationsSource
#1Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 11 authors...
The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, although reversible, inflammatory potential. This is due to their selective toxicity toward macrophages, and it is thus important to study the cellular responses of this cell type to silica nanoparticles to better understand the direct ...
10 CitationsSource
#1Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
#2Florent Villiers (CNRS: Centre national de la recherche scientifique)H-Index: 2
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 11 authors...
Silver nanoparticles (Ag-NPs) are used in a variety of consumers' goods. Their toxicological impact is currently intensely studied, mostly upon acute exposure, but their intracellular dissolution and fate is rather poorly documented. In this study, murine primary macrophages were exposed to a single high but non-lethal dose of Ag-NPs or to repeated, low doses of Ag-NPs. Cells were either collected immediately after acute exposure or after 72 h of recovery in the NP-free exposure medium. Ag intra...
14 CitationsSource
#1Catherine Aude-Garcia (CNRS: Centre national de la recherche scientifique)H-Index: 12
#2Bastien Dalzon (CNRS: Centre national de la recherche scientifique)H-Index: 2
Last. Thierry Rabilloud (CNRS: Centre national de la recherche scientifique)H-Index: 43
view all 10 authors...
The cellular responses of the J774 macrophage cell line to zinc oxide and zirconium oxide nanoparticles have been studied by a comparative quantitative, protein level based proteomic approach. The most prominent results have been validated by targeted approaches. These approaches have been carried out under culture conditions that stimulate mildly the aryl hydrocarbon receptor, thereby mimicking conditions that can be encountered in vivo in complex environments. The comparative approach with two...
21 CitationsSource
#1Lucie ArmandH-Index: 5
Last. Marie CarrièreH-Index: 32
view all 11 authors...
Although the biological effects of titanium dioxide nanoparticles (TiO2-NPs) have been studied for more than two decades, the mechanisms governing their toxicity are still unclear. We applied 2D-gel proteomics analysis on A549 epithelial alveolar cells chronically exposed for 2 months to 2.5 or 50 μg/mL of deeply characterized TiO2-NPs, in order to obtain comprehensive molecular responses that may reflect functional outcomes. We show that exposure to TiO2-NPs impacts the abundance of 30 protein ...
20 CitationsSource
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