Florian Lang
University of Tübingen
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Publications 1520
#1Ke Ma (University of Tübingen)H-Index: 1
#2Basma Sukkar (University of Tübingen)H-Index: 3
Last. Florian Lang (University of Tübingen)H-Index: 105
view all 9 authors...
Diabetes and chronic kidney disease (CKD) both trigger vascular osteogenic signaling and calcification leading to early death by cardiovascular events. Osteogenic signaling involves upregulation of the transcription factors CBFA1, MSX2, and SOX9, as well as alkaline phosphatase (ALP), an enzyme fostering calcification by degrading the calcification inhibitor pyrophosphate. In CKD, osteogenic signaling is triggered by hyperphosphatemia, which upregulates the serum and glucocorticoid-inducible kin...
Glucose uptake into lymphocytes is accomplished by non-concentrative glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4, GLUT6) and/or by the Na+-coupled glucose carrier SGLT1. The latter accumulates glucose against glucose gradients and is still effective at very low extracellular glucose concentrations. Signaling involved in SGLT1 expression and activity includes protein kinase A (PKA), protein kinase C (PKC), serum- and glucocorticoid-inducible kinase (SGK1), AMP-activated kinase (AMPK)...
#1Jibin Liu (Sichuan Agricultural University)H-Index: 2
Last. Florian LangH-Index: 105
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Pyrogallol, a polyphenolic component of Acacia nilotica has previously been reported to induce apoptosis of diverse cell types. Pyrogallol is in part effective by influencing gene expression and by interference with mitochondrial function. Despite lack of nuclei and mitochondria, erythrocytes may undergo eryptosis, a suicidal death apparent from phosphatidylserine translocation to the erythrocyte surface and cell shrinkage. Eryptosis is triggered by glucose depletion, by oxidation, by hyperosmot...
#1Ioana Alesutan (Johannes Kepler University of Linz)H-Index: 1
#2Franco MoritzH-Index: 13
Last. Silke S. HeinzmannH-Index: 12
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In chronic kidney disease, hyperphosphatemia is a key pathological factor promoting medial vascular calcification, a common complication associated with cardiovascular events and mortality. This active pathophysiological process involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs) via complex intracellular mechanisms that are still incompletely understood. Little is known about the effects of phosphate on the bioenergetic profile of VSMCs during the onset of ...
#1Zohreh Hosseinzadeh (University of Tübingen)H-Index: 18
#2Stefan Hauser (University of Tübingen)H-Index: 6
Last. Daniel L. Rathbun (University of Tübingen)
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Loss of function mutations of the chorein-encoding gene VPS13A lead to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium. Chorein upregulates the serum and glucocorticoid inducible kinase SGK1. Targets of SGK1 include the Na+/K+-ATPase, a pump required for cell survival. To explore whether chorein-deficiency affects Na+/K+ pump capacity, cortical neurons were differentiated from iPSCs generated from fibrob...
#1Ioana AlesutanH-Index: 28
#2Trang T.D. Luong (Charité)H-Index: 4
Last. Misael Estepa (Charité)H-Index: 1
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AIMS: Uromodulin is produced exclusively in the kidney and secreted into both urine and blood. Serum levels of uromodulin are correlated with kidney function and reduced in chronic kidney disease (CKD) patients, but physiological functions of serum uromodulin are still elusive. The present study investigated the role of uromodulin in medial vascular calcification, a key factor associated with cardiovascular events and mortality in CKD patients. METHODS AND RESULTS: Experiments were performed in ...
#1Ni Zeng (University of Tübingen)H-Index: 5
#1Ni Zeng (Sichuan University)H-Index: 1
Last. Diethelm Wallwiener (University of Tübingen)H-Index: 49
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LEFTY2 (endometrial bleeding associated factor; EBAF or LEFTYA), a cytokine released shortly before menstrual bleeding, is a negative regulator of cell proliferation and tumour growth. LEFTY2 down-regulates Na+/H+ exchanger activity with subsequent inhibition of glycolytic flux and lactate production in endometrial cancer cells. Glucose can be utilized not only for glycolysis but also for glycogen formation. Both glycolysis and glycogen formation require cellular glucose uptake which could be ac...
1 CitationsSource
#1Jodi D. Stookey (ASU: Arizona State University)H-Index: 1
#2Stavros A. Kavouras (ASU: Arizona State University)H-Index: 34
Last. Florian LangH-Index: 105
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Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) indicate that over 65% of adults aged 51–70 years in the U.S. do not meet hydration criteria. They have hyponatremia (serum sodium 145 mmol/L, spot urine volume <50 mL, and/or spot urine osmolality ≥500 mmol/kg). To explore potential public health implications of not meeting hydration criteria, data from the NHANES 2009–2012 and National Center for Health Statistics Linked Mortality Files for fastin...
2 CitationsSource
#1Tom Adomati (University of Duisburg-Essen)H-Index: 1
#2Lamin B. Cham (University of Duisburg-Essen)H-Index: 1
Last. Eyad Naser (University of Duisburg-Essen)H-Index: 1
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Summary Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknown. Here, we find that infection with the highly cytopathic vesicular stomatitis virus (VSV) leads to innate anergy for several days. Innate anergy is associated with inducti...
#1Nefeli Zacharopoulou (University of Tübingen)H-Index: 3
#1Nefeli Zacharopoulou (University of Tübingen)
Last. Christos Stournaras (UoC: University of Crete)H-Index: 42
view all 10 authors...
Recent studies revealed that the histone demethylase KDM2B regulates the epithelial markers E-Cadherin and ZO-1, the RhoA/B/C-small-GTPases and actin cytoskeleton organization, in DU-145 prostate- and HCT-116 colon-tumor cells. Here we addressed the role of KDM2B in the activation of Focal Adhesion Kinase (FAK)-signaling and its involvement in regulating tumor cell motility. We used RT-PCR for gene transcriptional analysis, Western blotting for the assessment of protein expression and activity a...