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Daphne L. van der A
Utrecht University
92Publications
41H-index
4,479Citations
Publications 92
Newest
#1Camille Lassale (UCL: University College London)H-Index: 6
#2Ioanna Tzoulaki (Imperial College London)H-Index: 47
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EPIC-CVD has been supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270 and MR/L003120/1), the British Heart Foundation (SP/09/002 and RG/08/014 and RG13/13/30194), and the UK National Institute of Health Research. EPIC Asturias was also supported by the Regional Government of Asturias. EPIC-Greece is also supported by the Hellenic Health Foundation. EPIC- Heidelberg was also supported by the German ...
Background Accumulation of problems in physical, psychological, cognitive, or social functioning is characteristic for frail individuals. Using a four-domain approach of frailty, this study explored how sociodemographic and lifestyle factors, life events and health are associated with frailty.
#1Elisabeth Hm TemmeH-Index: 11
Last.Daphne L. van der AH-Index: 41
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Background and objectives. High salt intake increases blood pressure and thereby the risk of chronic diseases. Food reformulation (or food product improvement) may lower the dietary intake of salt. This study describes the changes in salt contents of foods in the Dutch market over a five-year period (2011–2016) and differences in estimated salt intake over a 10-year period (2006–2015). Methods. To assess the salt contents of foods; we obtained recent data from chemical analyses and from food lab...
#1Luca A. Lotta (University of Cambridge)H-Index: 12
#2Stephen J. Sharp (University of Cambridge)H-Index: 64
Last.Beverley Balkau (University of Paris-Sud)H-Index: 100
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IMPORTANCE Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are as...
#1Nita G. Forouhi (University of Cambridge)H-Index: 77
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last.José María Huerta (Ciber)H-Index: 48
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Background: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. Methods and Findings: Plasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study across eight European countries. Country-specific hazard rati...
#1Rob Scott (Medical Research Council)H-Index: 78
#2Daniel F. Freitag (University of Cambridge)H-Index: 16
Last.Tibor V. Varga (Lund University)H-Index: 19
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Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and f...
#1Clara Podmore (University of Cambridge)H-Index: 4
#2Karina MeidtnerH-Index: 14
Last.Aurelio Barricarte (Ciber)H-Index: 78
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OBJECTIVE Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors ...
#1Sofus C. Larsen (AAU: Aalborg University)H-Index: 10
#2Lars ÄngquistH-Index: 18
Last.Nicholas J. WarehamH-Index: 162
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Background: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association. Objectives: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat,...
#1Kathryn L. Lunetta (BU: Boston University)H-Index: 66
#2Felix R. Day (University of Cambridge)H-Index: 25
Last.Chunyan He (IU: Indiana University)H-Index: 22
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More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only similar to 3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency proteincoding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per al...
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