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Daphne L. van der A
Utrecht University
Publications 92
Published on Feb 1, 2018in European Heart Journal 23.43
Camille Lassale6
Estimated H-index: 6
(University College London),
Ioanna Tzoulaki47
Estimated H-index: 47
(Imperial College London)
+ 46 AuthorsElisabete Vainio Weiderpass97
Estimated H-index: 97
EPIC-CVD has been supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270 and MR/L003120/1), the British Heart Foundation (SP/09/002 and RG/08/014 and RG13/13/30194), and the UK National Institute of Health Research. EPIC Asturias was also supported by the Regional Government of Asturias. EPIC-Greece is also supported by the Hellenic Health Foundation. EPIC- Heidelberg was also supported by the German ...
49 Citations Source Cite
Published on Dec 1, 2017in BMC Geriatrics 2.87
Sandra H. van Oostrom8
Estimated H-index: 8
Daphne L. van der A41
Estimated H-index: 41
+ 5 AuthorsAnnemieke M. W. Spijkerman45
Estimated H-index: 45
Background Accumulation of problems in physical, psychological, cognitive, or social functioning is characteristic for frail individuals. Using a four-domain approach of frailty, this study explored how sociodemographic and lifestyle factors, life events and health are associated with frailty.
8 Citations Source Cite
Published on Jul 22, 2017in Nutrients 4.20
Elisabeth Hm Temme11
Estimated H-index: 11
Marieke Ah Hendriksen10
Estimated H-index: 10
+ 4 AuthorsDaphne L. van der A41
Estimated H-index: 41
Background and objectives. High salt intake increases blood pressure and thereby the risk of chronic diseases. Food reformulation (or food product improvement) may lower the dietary intake of salt. This study describes the changes in salt contents of foods in the Dutch market over a five-year period (2011–2016) and differences in estimated salt intake over a 10-year period (2006–2015). Methods. To assess the salt contents of foods; we obtained recent data from chemical analyses and from food lab...
3 Citations Source Cite
Published on Oct 4, 2016in JAMA 47.66
Luca A. Lotta11
Estimated H-index: 11
(University of Cambridge),
Stephen J. Sharp64
Estimated H-index: 64
(University of Cambridge)
+ 38 AuthorsBeverley Balkau99
Estimated H-index: 99
(University of Paris-Sud)
IMPORTANCE Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are as...
112 Citations Source Cite
Published on Jul 19, 2016in PLOS Medicine 11.68
Nita G. Forouhi77
Estimated H-index: 77
(University of Cambridge),
Fumiaki Imamura27
Estimated H-index: 27
(University of Cambridge)
+ 44 AuthorsJosé María Huerta48
Estimated H-index: 48
Background: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. Methods and Findings: Plasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study across eight European countries. Country-specific hazard rati...
47 Citations Source Cite
Published on Jun 1, 2016
Rob Scott78
Estimated H-index: 78
(Medical Research Council),
Daniel F. Freitag16
Estimated H-index: 16
(University of Cambridge)
+ 136 AuthorsTibor V. Varga19
Estimated H-index: 19
(Lund University)
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and f...
39 Citations Source Cite
Published on Apr 1, 2016in Diabetes Care 13.40
Clara Podmore4
Estimated H-index: 4
(University of Cambridge),
Karina Meidtner14
Estimated H-index: 14
+ 43 AuthorsAurelio Barricarte78
Estimated H-index: 78
OBJECTIVE Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors ...
20 Citations Source Cite
Published on Mar 1, 2016in Journal of Nutrition 4.40
Sofus C. Larsen10
Estimated H-index: 10
(Aalborg University),
Lars Ängquist18
Estimated H-index: 18
+ 18 AuthorsNicholas J. Wareham162
Estimated H-index: 162
Background: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association. Objectives: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat,...
2 Citations Source Cite
Published on Nov 1, 2015in Nature Communications 12.35
Kathryn L. Lunetta66
Estimated H-index: 66
(Boston University),
Felix R. Day25
Estimated H-index: 25
(University of Cambridge)
+ 118 AuthorsChunyan He22
Estimated H-index: 22
(Indiana University)
More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only similar to 3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency proteincoding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are associated with age at menarche (minor allele frequencies 0.08-4.6%; effect sizes 0.08-1.25 years per al...
20 Citations Source Cite