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Jung Bok Lee
Yonsei University
75Publications
19H-index
1,276Citations
Publications 74
Newest
Abstract Epiphora is the overflow of tears typically caused by obstruction or occlusion of the nasolacrimal duct. More attention is required to address this global health issue owing to the increase in air pollution. Implantation of a silicone stent is the preferred treatment for epiphora; however, introducing a silicone stent into a narrow duct with complex geometry is challenging as it requires guidance by a sharp metal needle. Additionally, silicone can cause adverse reactions such as biofilm...
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#1Jae-Hyun Park (Konkuk University)H-Index: 1
#2Jeong-Kee Yoon (Yonsei University)H-Index: 1
Last.Dae-Hyun Kim (Yonsei University)H-Index: 2
view all 12 authors...
Various treatment methods for tracheal defects have been attempted, such as artificial implants, allografts, autogenous grafts, and tissue engineering; however, no perfect method has been established. We attempted to create an effective artificial trachea via a tissue engineering method using 3D bio-printing. A multi-layered scaffold was fabricated using a 3D printer. Polycaprolactone (PCL) and hydrogel were used with nasal epithelial and auricular cartilage cells in the printing process. An art...
2 CitationsSource
#1Yong Cheol Shin (Yonsei University)H-Index: 12
#2Jung Bok Lee (Yonsei University)H-Index: 19
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
view all 18 authors...
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#1Jung Bok Lee (Yonsei University)H-Index: 19
#2Jeong Su Park (Yonsei University)H-Index: 7
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
view all 10 authors...
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#1Dae-Hyun Kim (Yonsei University)H-Index: 2
#2Jung Bok Lee (Yonsei University)H-Index: 19
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
view all 17 authors...
To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain health...
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Human mesenchymal stem cells (hMSCs) have been widely studied for therapeutic development in tissue engineering and regenerative medicine. They can be harvested from human donors via tissue biopsies, such as bone marrow aspiration, and cultured to reach clinically relevant cell numbers. However, an unmet issue lies in the fact that the hMSC donors for regenerative therapies are more likely to be of advanced age. Their stem cells are not as potent compared to those of young donors, and continue t...
2 CitationsSource
#1Jung Bok Lee (Yonsei University)H-Index: 19
#2Young Min Shin (Yonsei University)H-Index: 3
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
view all 5 authors...
Stimuli-responsive biomaterials undergo significant alterations in material structure and property in response to changes of local environmental factors (e.g. pH, temperature, enzyme activation, and water absorption). In particular, reactive oxygen species (ROS) is considered as a major stimulus because over-production of ROS involves most types of major pathogenesis. The application of ROS-responsive biomaterials requires suitable material designs to program user-defined changes of their struct...
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Human bone marrow derived mesenchymal stem cells (hMSCs) hold great promise for regenerative medicine due to their multipotent differentiation capacity and immunomodulatory capabilities. Substantial research has elucidated mechanisms by which extracellular cues regulate hMSC fate decisions, but considerably less work has addressed how material properties can be leveraged to maintain undifferentiated stem cells. Here, we show that synthetic culture substrates designed to exhibit moderate cell-rep...
5 CitationsSource
#1Eunmin Kim (Yonsei University)H-Index: 14
#2S. Kong (Yonsei University)
Last.Sung Yong Kang (Yonsei University)H-Index: 14
view all 16 authors...
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#1Jaegab LeeH-Index: 19
#2Jung Bok LeeH-Index: 19
Last.Seung-Boo JungH-Index: 42
view all 5 authors...
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