Jung Bok Lee
Vanderbilt University
Composite materialMaterials scienceBone regenerationTissue engineeringScaffold
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Publications 69
#1Dae-Hyun Kim (Yonsei University)H-Index: 5
#2Jung Bok Lee (Yonsei University)H-Index: 20
Last. Hak-Joon Sung (Yonsei University)H-Index: 23
view all 17 authors...
To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain health...
Human mesenchymal stem cells (hMSCs) have been widely studied for therapeutic development in tissue engineering and regenerative medicine. They can be harvested from human donors via tissue biopsies, such as bone marrow aspiration, and cultured to reach clinically relevant cell numbers. However, an unmet issue lies in the fact that the hMSC donors for regenerative therapies are more likely to be of advanced age. Their stem cells are not as potent compared to those of young donors, and continue t...
2 CitationsSource
#1Yunki Lee (Vandy: Vanderbilt University)H-Index: 4
#1Yunki LeeH-Index: 17
Last. Hak-Joon Sung (Vandy: Vanderbilt University)H-Index: 23
view all 8 authors...
Directing angiogenic differentiation of mesenchymal stem cells (MSCs) still remains challenging for successful tissue engineering. Without blood vessel formation, stem cell-based approaches are unable to fully regenerate damaged tissues due to limited support for cell viability and desired tissue/organ functionality. Herein, we report in situ cross-linkable gelatin−hydroxyphenyl propionic acid (GH) hydrogels that can induce pro-angiogenic profiles of MSCs via purely material-driven effects. This...
9 CitationsSource
Human bone marrow derived mesenchymal stem cells (hMSCs) hold great promise for regenerative medicine due to their multipotent differentiation capacity and immunomodulatory capabilities. Substantial research has elucidated mechanisms by which extracellular cues regulate hMSC fate decisions, but considerably less work has addressed how material properties can be leveraged to maintain undifferentiated stem cells. Here, we show that synthetic culture substrates designed to exhibit moderate cell-rep...
6 CitationsSource
#1Jaegab LeeH-Index: 19
#2Jung Bok LeeH-Index: 20
Last. Seung-Boo JungH-Index: 43
view all 5 authors...
The effect of dynamic compressive stimulation on MG-63 cell proliferation on an auxetic PLGA scaffold was investigated. The estimated Poisson ratio of the prepared auxetic scaffold specimens was approximately (−)0.07, while the Poisson ratio estimated for conventional scaffold specimens was (
1 CitationsSource
#1Hong Jin Choi (Inje University)H-Index: 3
#2Jun Jae Lee (Vandy: Vanderbilt University)H-Index: 2
Last. Jeong Koo Kim (Inje University)H-Index: 16
view all 8 authors...
Background Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell.
4 CitationsSource
#1Spencer W. Crowder (Vandy: Vanderbilt University)H-Index: 14
#2Daniel A. Balikov (Vandy: Vanderbilt University)H-Index: 10
Last. Hak-Joon Sung (Yonsei University)H-Index: 23
view all 8 authors...
Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.
5 CitationsSource
#1Min Soo Bae (Kyung Hee University)H-Index: 16
#2Na Re Ko (Kyung Hee University)H-Index: 4
Last. Il Keun Kwon (Kyung Hee University)H-Index: 42
view all 13 authors...
In this study, the effect of novel BMP-2-loaded photo-cured hydrogels on in vitro and in vivo osteogenesis were explored. The well-defined HA-heparin hydrogel was prepared by a photopolymerization of aminoethyl methacrylate (AEMA) grafted hyaluronic acid (HA) and AEMA-grafted heparin. Subsequently, the resulting hydrogels contained BMP-2 at different concentrations. First, a series of BMP-2-loaded hydrogels were characterized to determine their mechanical properties and release profiles. The res...
4 CitationsSource
Aug 1, 2016 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Virginia Pensabene (University of Leeds)H-Index: 16
#2S.W. Crowder (Imperial College London)H-Index: 1
Last. Hak-Joon Sung (Vandy: Vanderbilt University)H-Index: 23
view all 5 authors...
The blood-brain barrier (BBB) plays a critical role in brain homeostasis at the cellular and global level. Mimicking the selective permeability and transport properties of the BBB to specific molecules and cells remains a significant challenge towards the development of a physiologically relevant in vitro BBB model. In this study, we developed electrospun poly (e-caprolactone) (PCL) and polyethylene glycol (PEG) copolymer membranes that supported different cellular components of the neurovascula...
1 CitationsSource